[ { "phenotype_id": "PH461", "phenotype_version_id": 922, "name": "Smoking Status", "definition": "A cohort study based on primary care data from the QResearch database will include patients with one of the three common tumours: breast, bowel and prostate. The primary outcome will be overall survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare the survival of patients with cancer taking VGSC-inhibiting drugs (including anticonvulsants and class I antiarrhythmic agents) with patients with cancer not exposed to these drugs, adjusting for age and sex. Exposure to VGSC-inhibiting drugs will be defined as having at least one prescription for these drugs prior to cancer diagnosis. High and low exposure groups will be identified based on the length of use. A number of sensitivity and secondary analyses will be conducted.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenburry, Exposure to sodium channel-inhibiting drugs and cancer survival protocol for a cohort study using the QResearch primary care database. BMJ Open, 4:e006604 2014." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:20:42.581528Z", "author": "Caroline Fairhurst, Ian Watt, Fabiola Martin, Martin Bland, William J Brackenbury", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:20:42.581557Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "QResearch®", "value": 24, "uid": "777d6ac1-6879-4750-9a85-9e42d28bb8d4", "url": "https://healthdatagateway.org/en/dataset/794", "datasource_id": 794 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1998 - 31/12/2013", "concept_information": [ { "concept_id": 1820, "concept_version_id": 4778, "concept_name": "Smoking Status - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH461", "phenotype_version_id": 922, "phenotype_name": "Smoking Status", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "137-1", "description": "Smoker - amount smoked", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1371", "description": "Never smoked tobacco", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1371-1", "description": "Non-smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1372", "description": "Trivial smoker - < 1 cig/day", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1372-1", "description": "Occasional smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1373", "description": "Light smoker - 1-9 cigs/day", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1374", "description": "Moderate smoker - 10-19 cigs/d", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1375", "description": "Heavy smoker - 20-39 cigs/day", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1376", "description": "Very heavy smoker - 40+cigs/d", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1377", "description": "Ex-trivial smoker (<1/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1378", "description": "Ex-light smoker (1-9/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1379", "description": "Ex-moderate smoker (10-19/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137a", "description": "Pipe tobacco consumption", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137A", "description": "Ex-heavy smoker (20-39/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137b", "description": "Ready to stop smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137B", "description": "Ex-very heavy smoker (40+/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137c", "description": "Thinking about stopping smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137C", "description": "Keeps trying to stop smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137d", "description": "Not interested in stopping smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137D", "description": "Admitted tobacco cons untrue ?", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137e", "description": "Smoking restarted", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137E", "description": "Tobacco consumption unknown", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137f", "description": "Reason for restarting smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137F", "description": "Ex-smoker - amount unknown", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137F-99", "description": "EX-Smoker NOS", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137g", "description": "Cigarette pack-years", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137G", "description": "Trying to give up smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137h", "description": "Minutes from waking to first tobacco consumption", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137H", "description": "Pipe smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137i", "description": "Ex-tobacco chewer", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137I", "description": "Passive smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137I0", "description": "Exposed to tobacco smoke at home", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137j", "description": "Ex-cigarette smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137J", "description": "Cigar smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137k", "description": "Refusal to give smoking status", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137K", "description": "Stopped smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137K0", "description": "Recently stopped smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137l", "description": "Ex roll-up cigarette smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137L", "description": "Current non-smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137L-99", "description": "Tobacco Consumption Nil", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137m", "description": "Failed attempt to stop smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137M", "description": "Rolls own cigarettes", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137n", "description": "Total time smoked", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137N", "description": "Ex pipe smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137o", "description": "Waterpipe tobacco consumption", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137O", "description": "Ex cigar smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137P", "description": "Cigarette smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137P-1", "description": "Smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Q", "description": "Smoking started", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Q-1", "description": "Smoking restarted", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137R", "description": "Current smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137S", "description": "Ex smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137T", "description": "Date ceased smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137U", "description": "Not a passive smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137V", "description": "Smoking reduced", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137W", "description": "Chews tobacco", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137X", "description": "Cigarette consumption", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Y", "description": "Cigar consumption", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Z", "description": "Tobacco consumption NOS", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p", "description": "Smoking cessation milestones", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p0", "description": "Negotiated date for cessation of smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p1", "description": "Smoking status at 4 weeks", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p2", "description": "Smoking status between 4 and 52 weeks", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p3", "description": "Smoking status at 52 weeks", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p4", "description": "Smoking free weeks", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p7", "description": "Smoking status at 12 weeks", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13WF-1", "description": "Smoker in the family", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "9ko", "description": "Current smoker annual review - enhanced services admin", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "9ko-1", "description": "Current smoker annual review", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "ASDFGNO1", "description": "Non Smoker - Nos", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON1024", "description": "Rolls own cigarettes", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON1025", "description": "Current Smoker NOS", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON1026", "description": "Ex-cigar smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON1027", "description": "Ex- Rolled Tobacco Smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON1028", "description": "Ex-smoker NOS", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON320", "description": "Smoking Status", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON321", "description": "Cigarette smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON322", "description": "Ex-Cigarette Smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON324", "description": "Ex-pipe smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON326", "description": "Current smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON327", "description": "Past smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTON328", "description": "Date stopped smoking", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR11", "description": "Grade B light smoker (1-10/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR12", "description": "Grade C moderate smoker (11-20/day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONGR13", "description": "Grade D heavy smoker (>20 Day)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONSM2", "description": "Smoking Age", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONSM3", "description": "Smoking Age Started", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONSM4", "description": "Smoking Age Ceased", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EGTONSM6", "description": "Smoking clinic", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQEX4", "description": "Ex-tobacco chewer", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQPR396", "description": "Primary carer current smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQSM14", "description": "Smoking increased", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQSN1", "description": "Snuff use", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQTO12", "description": "Total time smoked", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISNQWA11", "description": "Waterpipe tobacco consumption", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISOTS1", "description": "Other smoking information", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQCO3", "description": "Carbon monoxide validation confirms smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQDA1", "description": "Date of last cigarette", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISQGR1", "description": "Gradual smoking reduction", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "EMISSMRE1", "description": "Smoker (Read codes)", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "PCSDT1DE9", "description": "Dependent smoker", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "PCSDT1HE1", "description": "Heavy smoker review due", "attributes": { "Entity type": "res17: Smoking status", "Category": "test", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/sqp2-c807", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 922, "version_name": "Smoking Status", "version_date": "2021-10-06T16:20:42.608406Z", "is_published": true, "is_latest": true } ] } ]