[ { "phenotype_id": "PH462", "phenotype_version_id": 924, "name": "Smoking Status", "definition": "Introduction:\n\nVoltage-gated sodium channel (VGSC)- inhibiting drugs are commonly used to treat epilepsy and cardiac arrhythmia. VGSCs are also widely expressed in various cancers, including those of the breast, bowel and prostate. A number of VGSCinhibiting drugs have been shown to inhibit cancer cell proliferation, invasion, tumour growth and metastasis in preclinical models, suggesting that VGSCs may be novel molecular targets for cancer treatment. Surprisingly, we previously found that prior exposure to VGSC-inhibiting drugs may be associated with reduced overall survival in patients with cancer, but we were unable to control for the cause of death or indication for prescription. The purpose of the present study is to interrogate a different database to further investigate the relationship between VGSC-inhibiting drugs and cancer-specific survival.\n\n\nMethods and analysis: \n\nA cohort study using primary care data from the Clinical Practice Research Datalink database will include patients with diagnosis of breast, bowel and prostate cancer (13 000). The primary outcome will be cancer-specific survival from the date of cancer diagnosis. Cox proportional hazards regression will be used to compare survival of patients taking VGSC-inhibiting drugs (including antiepileptic drugs and class I antiarrhythmic agents) with patients with cancer not taking these drugs, adjusting for cancer type, age and sex. Drug exposure will be treated as a time-varying covariate to account for potential immortal time bias. Various sensitivity and secondary analyses will be performed.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury, Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database. BMJ Open, 6(e0111661), 2016." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:20:44.260479Z", "author": "Caroline Fairhust, Fabiola Martin, Ian Watt, Tim Doran, Martin Bland, William J Brackenbury", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:20:44.260507Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Lifestyle risk factor", "value": "4" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "start - 31/12/2014", "concept_information": [ { "concept_id": 1821, "concept_version_id": 4780, "concept_name": "Smoking Status - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH462", "phenotype_version_id": 924, "phenotype_name": "Smoking Status", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "137..11", "description": "Smoker - amount smoked", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1371.11", "description": "Non-smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "1372.11", "description": "Occasional smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137a.00", "description": "Pipe tobacco consumption", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137A.00", "description": "Ex-heavy smoker (20-39/day)", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137b.00", "description": "Ready to stop smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137B.00", "description": "Ex-very heavy smoker (40+/day)", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137c.00", "description": "Thinking about stopping smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137C.00", "description": "Keeps trying to stop smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137d.00", "description": "Not interested in stopping smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137D.00", "description": "Admitted tobacco cons untrue ?", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137e.00", "description": "Smoking restarted", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137E.00", "description": "Tobacco consumption unknown", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137f.00", "description": "Reason for restarting smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137F.00", "description": "Ex-smoker - amount unknown", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137g.00", "description": "Cigarette pack-years", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137G.00", "description": "Trying to give up smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137h.00", "description": "Minutes from waking to first tobacco consumption", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137H.00", "description": "Pipe smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137i.00", "description": "Ex-tobacco chewer", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137I.00", "description": "Passive smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137I000", "description": "Exposed to tobacco smoke at home", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137j.00", "description": "Ex-cigarette smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137J.00", "description": "Cigar smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137k.00", "description": "Refusal to give smoking status", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137K.00", "description": "Stopped smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137K000", "description": "Recently stopped smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137l.00", "description": "Ex roll-up cigarette smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137L.00", "description": "Current non-smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137m.00", "description": "Failed attempt to stop smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137M.00", "description": "Rolls own cigarettes", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137n.00", "description": "Total time smoked", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137N.00", "description": "Ex pipe smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137o.00", "description": "Waterpipe tobacco consumption", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137O.00", "description": "Ex cigar smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137P.00", "description": "Cigarette smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137P.11", "description": "Smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Q.00", "description": "Smoking started", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Q.11", "description": "Smoking restarted", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137R.00", "description": "Current smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137S.00", "description": "Ex smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137T.00", "description": "Date ceased smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137U.00", "description": "Not a passive smoker", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137V.00", "description": "Smoking reduced", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137W.00", "description": "Chews tobacco", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137X.00", "description": "Cigarette consumption", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Y.00", "description": "Cigar consumption", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "137Z.00", "description": "Tobacco consumption NOS", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p..00", "description": "Smoking cessation milestones", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p0.00", "description": "Negotiated date for cessation of smoking", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p1.00", "description": "Smoking status at 4 weeks", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p2.00", "description": "Smoking status between 4 and 52 weeks", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p3.00", "description": "Smoking status at 52 weeks", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p4.00", "description": "Smoking free weeks", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p5.00", "description": "Smoking cessation programme start date", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13p7.00", "description": "Smoking status at 12 weeks", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "13WF.11", "description": "Smoker in the family", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "9ko..00", "description": "Current smoker annual review - enhanced services admin", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "9ko..11", "description": "Current smoker annual review", "attributes": { "Entity type": "res47: Smoking status", "Category": "test", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/vhbe-2707", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 924, "version_name": "Smoking Status", "version_date": "2021-10-06T16:20:44.287423Z", "is_published": true, "is_latest": true } ] } ]