[ { "phenotype_id": "PH464", "phenotype_version_id": 928, "name": "Antiepileptic", "definition": "Importance:\n\nPeople with epilepsy are at increased risk of mortality, but, to date, the cause-specific risks of all unnatural causes have not been reported.\n\n\nObjective:\n\nTo estimate cause-specific unnatural mortality risks in people with epilepsy and to identify the medication types involved in poisoning deaths.\n\n\nDesign, Setting, and Participants:\n\nThis population-based cohort study used 2 electronic primary care data sets linked to hospitalization and mortality records, the Clinical Practice Research Datalink (CPRD) in England (from January 1, 1998, to March 31, 2014) and the Secure Anonymised Information Linkage (SAIL) Databank in Wales (from January 1, 2001, to December 31, 2014). Each person with epilepsy was matched on age (within 2 years), sex, and general practice with up to 20 individuals without epilepsy. Unnatural mortality was determined using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes V01 through Y98 in the Office for National Statistics mortality records. Hazard ratios (HRs) were estimated in each data set using a stratified Cox proportional hazards model, and meta-analyses were conducted using DerSimonian and Laird random-effects models. The analysis was performed from January 5, 2016, to November 16, 2017.\n\n\nExposures:\n\nPeople with epilepsy were identified using primary care epilepsy diagnoses and associated antiepileptic drug prescriptions.\n\n\nMain Outcomes and Measures:\n\nHazard ratios (HRs) for unnatural mortality and the frequency of each involved medication type estimated as a percentage of all medication poisoning deaths.\n\n\nResults: \n\nIn total, 44678 individuals in the CPRD and 14 051 individuals in the SAIL Databank were identified in the prevalent epilepsy cohorts, and 891 429 (CPRD) and 279 365 (SAIL) individuals were identified in the comparison cohorts. In both data sets, 51% of the epilepsy and comparison cohorts were male, and the median age at entry was 40 years (interquartile range, 25-60 years) in the CPRD cohorts and 43 years (interquartile range, 24-64 years) in the SAIL cohorts. People with epilepsy were significantly more likely to die of any unnatural cause (HR, 2.77; 95% CI, 2.43-3.16), unintentional injury or poisoning (HR, 2.97; 95% CI, 2.54-3.48) or suicide (HR, 2.15; 95% CI, 1.51-3.07) than people in the comparison cohort. Particularly large risk increases were observed in the epilepsy cohorts for unintentional medication poisoning (HR, 4.99; 95% CI, 3.22-7.74) and intentional self-poisoning with medication (HR, 3.55; 95% CI, 1.01-12.53). Opioids (56.5% [95% CI, 43.3%-69.0%]) and psychotropic medication (32.3% [95% CI, 20.9%-45.3%)] were more commonly involved than antiepileptic drugs (9.7% [95% CI, 3.6%-19.9%]) in poisoning deaths in people with epilepsy.\n\n\nConclusions and Relevance:\n\nCompared with people without epilepsy, people with epilepsy are at increased risk of unnatural death and thus should be adequately advised about unintentional injury prevention and monitored for suicidal ideation, thoughts, and behaviors. The suitability and toxicity of concomitant medication should be considered when prescribing for comorbid conditions.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Hayley C Gorton, Roger T Webb, Mathew J Carr, Marcos Delpozo-Banos, Ann John, Darren M Ashcroft, Risk of Unnatural Mortality in People With Epilepsy. JAMA Neurology, 75(8), 929-038, 2018." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:20:50.076422Z", "author": "Hayley C Gorton, Roger T Webb, Mathew J Carr, Marcos Delpozo-Banos, Ann John, Darren M Ashcroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:20:50.076449Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1998 - 31/03/2014", "concept_information": [ { "concept_id": 1823, "concept_version_id": 4784, "concept_name": "Antiepileptic - Primary Care", 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"code": "dnbc.", "description": "epilim chrono 200 m/r tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbC.", "description": "epival cr 500mg m/r tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbd.", "description": "epilim chrono 300 m/r tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbe.", "description": "epilim chrono 500 m/r tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbF.", "description": "episenta 150mg m/r capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbG.", "description": "episenta 300mg m/r capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbH.", "description": "episenta 500mg/sach m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbI.", "description": "episenta 1g/sachet m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbJ.", "description": "sodum valproate 150mg m/r caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbK.", "description": "sodum valproate 300mg m/r caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbL.", "description": "sod valproate 500mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbM.", "description": "sod valprote 1g/sach m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbn.", "description": "sod valproate 50mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbo.", "description": "sod valproate 100mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbp.", "description": "sod valproate 250mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbP.", "description": "epilim chrono 50mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbq.", "description": "sod valproate 750mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbQ.", "description": "epilim chrono 100mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbr.", "description": "sod valproate 200mg m/r tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbR.", "description": "epilim chrono 250mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbs.", "description": "sod valproate 300mg m/r tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbS.", "description": "epilim chrono 500mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbt.", "description": "sod valproate 500mg m/r tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbT.", "description": "epilim chrono 750mg m/r grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbU.", "description": "epilim chrono 1g m/r granules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbv.", "description": "sod valproate 100mg crush tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbw.", "description": "*sodium valproate 200mg tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbx.", "description": "*sodium valproate 500mg tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnby.", "description": "sod. valproate 200mg/5ml sfliq", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnbz.", "description": "sodium valproate 200mg/5ml syr", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnc..", "description": "clobazam [epilepsy only]", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnc1.", "description": "*clobazam sls 10mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dne..", "description": "vigabatrin", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dne1.", "description": "vigabatrin 500mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dne2.", "description": "sabril 500mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dne3.", "description": "vigabatrin 500mg pdr sachets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dne4.", "description": "sabril 500mg powder sachets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf..", "description": "lamotrigine", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf1.", "description": "lamotrigine 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf2.", "description": "lamotrigine 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf3.", "description": "lamictal 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf4.", "description": "lamictal 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf5.", "description": "lamotrigine 25mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf6.", "description": "lamictal 25mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf7.", "description": "lamictal 5mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf8.", "description": "lamictal 25mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnf9.", "description": "lamictal 100mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfA.", "description": "lamotrigine 5mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfB.", "description": "lamotrigine 25mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfC.", "description": "lamotrigine 100mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfD.", "description": "lamictal 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfE.", "description": "lamotrigine 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfF.", "description": "*lamictal monotherapy pack", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfG.", "description": "*lamictal valproate add-on pck", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfH.", "description": "*lamictal non-valproate pack", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfJ.", "description": "lamictal 2mg dispersible tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnfz.", "description": "lamotrigine 2mg disp tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh..", "description": "valproic acid", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh1.", "description": "convulex 150mg e/c capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh2.", "description": "convulex 300mg e/c capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh3.", "description": "convulex 500mg e/c capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh4.", "description": "valproic acid 150mg e/c caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh5.", "description": "valproic acid 300mg e/c caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh6.", "description": "valproic acid 500mg e/c caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh7.", "description": "depakote 250mg e/c tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnh8.", "description": "depakote 500mg e/c tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnhy.", "description": "valproic acid 500mg e/c tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnhz.", "description": "valproic acid 250mg e/c tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj..", "description": "gabapentin", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj1.", "description": "gabapentin 100mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj2.", "description": "gabapentin 300mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj3.", "description": "gabapentin 400mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj4.", "description": "neurontin 100mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj5.", "description": "neurontin 300mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj6.", "description": "neurontin 400mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj7.", "description": "neurontin 600mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj8.", "description": "neurontin 800mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnj9.", "description": "*neurontin 300mg/600mg pack", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnjA.", "description": "gabapentin 50mg/ml oral soln", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnjx.", "description": "*gabapentn 300mg cap/600mg tab", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnjy.", "description": "gabapentin 600mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnjz.", "description": "gabapentin 800mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk..", "description": "topiramate", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk1.", "description": "topiramate 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk2.", "description": "topiramate 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk3.", "description": "topiramate 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk4.", "description": "topamax 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk5.", "description": "topamax 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk6.", "description": "topamax 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk7.", "description": "topiramate 25mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk8.", "description": "topamax 25mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnk9.", "description": "topiramate 15mg beads in caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnkA.", "description": "topiramate 25mg beads in caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnkB.", "description": "topamax sprinkle 15mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnkC.", "description": "topamax sprinkle 25mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnkD.", "description": "topiramate 50mg beads in caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnkE.", "description": "topamax sprinkle 50mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl..", "description": "tiagabine", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl1.", "description": "tiagabine 5mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl2.", "description": "tiagabine 10mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl3.", "description": "tiagabine 15mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl4.", "description": "gabitril 5mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl5.", "description": "gabitril 10mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnl6.", "description": "gabitril 15mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnm..", "description": "oxcarbazepine", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnm1.", "description": "trileptal 150 tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnm2.", "description": "trileptal 300 tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnm3.", "description": "trileptal 600 tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnm4.", "description": "trileptal 60mg/ml s/f susp", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnmw.", "description": "oxcarbazepine 60mg/ml s/f susp", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnmx.", "description": "oxcarbazepine 150mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnmy.", "description": "oxcarbazepine 300mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnmz.", "description": "oxcarbazepine 600mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno..", "description": "levetiracetam", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno1.", "description": "keppra 250mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno2.", "description": "keppra 500mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno3.", "description": "keppra 1g tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno4.", "description": "keppra 750mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno5.", "description": "keppra 100mg/ml s/f oral soln", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno7.", "description": "desitrend 250mg/sach granules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno8.", "description": "desitrend 500mg/sach granules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dno9.", "description": "desitrend 1g/sachet granules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnoA.", "description": "desitrend 100mg/ml oral soln", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnor.", "description": "levetiracetam 1g/sach granules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnos.", "description": "levetiracetam 500mg/sach grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnot.", "description": "levetiracetam 250mg/sach grans", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnov.", "description": "levetiractam 100mg/ml s/f soln", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnow.", "description": "levetiracetam 750mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnox.", "description": "levetiracetam 1g tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnoy.", "description": "levetiracetam 500mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnoz.", "description": "levetiracetam 250mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp..", "description": "pregabalin", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp1.", "description": "lyrica 25mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp2.", "description": "lyrica 50mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp3.", "description": "lyrica 75mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp4.", "description": "lyrica 100mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp5.", "description": "lyrica 150mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp6.", "description": "lyrica 200mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp7.", "description": "lyrica 300mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp8.", "description": "lyrica 225mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnp9.", "description": "lyrica 20mg/1ml oral solution", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpr.", "description": "pregabalin 20mg/1ml solution", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnps.", "description": "pregabalin 225mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpt.", "description": "pregabalin 300mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpu.", "description": "pregabalin 200mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpv.", "description": "pregabalin 100mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpw.", "description": "pregabalin 150mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpx.", "description": "pregabalin 75mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpy.", "description": "pregabalin 50mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnpz.", "description": "pregabalin 25mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq..", "description": "zonisamide", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq1.", "description": "zonisamide 25mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq2.", "description": "zonisamide 50mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq3.", "description": "zonisamide 100mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq4.", "description": "zonegran 25mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq5.", "description": "zonegran 50mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnq6.", "description": "zonegran 100mg capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnr..", "description": "rufinamide", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnr1.", "description": "inovelon 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnr2.", "description": "inovelon 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnr3.", "description": "inovelon 400mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnr4.", "description": "inovelon 40mg/ml oral susp", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnrw.", "description": "rufinamide 40mg/ml oral susp", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnrx.", "description": "rufinamide 400mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnry.", "description": "rufinamide 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnrz.", "description": "rufinamide 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt..", "description": "lacosamide", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt2.", "description": "*vimpat 15mg/1ml s/f liquid", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt3.", "description": "vimpat 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt4.", "description": "vimpat 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt5.", "description": "vimpat 150mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt6.", "description": "vimpat 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt8.", "description": "*lacosamide 15mg/1ml s/f liq", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnt9.", "description": "lacosamide 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dntA.", "description": "lacosamide 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dntB.", "description": "lacosamide 150mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dntC.", "description": "lacosamide 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dntD.", "description": "vimpat 10mg/1ml syrup", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dntE.", "description": "lacosamide 10mg/1ml s/f liquid", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnu..", "description": "eslicarbazepine", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnu1.", "description": "zebinix 800mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnu2.", "description": "eslicarbazpn acetat 800mg tabs", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv..", "description": "retigabine", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv1.", "description": "trobalt 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv2.", "description": "trobalt 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv3.", "description": "trobalt 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv4.", "description": "trobalt 300mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv5.", "description": "trobalt 400mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv6.", "description": "trobalt tabs initiation pack", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv7.", "description": "retigabine 50mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv8.", "description": "retigabine 100mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnv9.", "description": "retigabine 200mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnvA.", "description": "retigabine 300mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnvB.", "description": "retigabine 400mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnvC.", "description": "retigabin 50mg+100mg tabs pack", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw..", "description": "perampanel", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw1.", "description": "fycompa 2mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw2.", "description": "fycompa 4mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw3.", "description": "fycompa 6mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw4.", "description": "fycompa 8mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw5.", "description": "fycompa 10mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnw6.", "description": "fycompa 12mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnwu.", "description": "perampanel 12mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnwv.", "description": "perampanel 10mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnww.", "description": "perampanel 8mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnwx.", "description": "perampanel 6mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnwy.", "description": "perampanel 4mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "dnwz.", "description": "perampanel 2mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k81..", "description": "acetazolamide [glaucoma]", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k811.", "description": "*diamox sustets 500mg m/r caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k812.", "description": "diamox 250mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k815.", "description": "diamox sr 250mg m/r capsules", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k81w.", "description": "acetazolamide 250mg m/r caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k81x.", "description": "*acetazolamide 500mg m/r caps", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "k81y.", "description": "acetazolamide 250mg tablets", "attributes": { "Entity type": "res55: antiepileptic", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/0tdf-4m77", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 928, "version_name": "Antiepileptic", "version_date": "2021-10-06T16:20:50.108507Z", "is_published": true, "is_latest": true } ] } ]