[ { "phenotype_id": "PH484", "phenotype_version_id": 968, "name": "Cardiovascular Disease", "definition": "Objective:\n\nTo investigate the association between smoking status and smoking cessation with mortality in patients with rheumatoid arthritis (RA).\n\n\nMethods:\n\nAn incident cohort of patients with RA was identified using the Clinical Practice Research Datalink, a database of UK primary care electronic medical records. Time-varying smoking status, years of cessation, and amount smoked were determined frompatients’medical records. The date and underlying cause of deathwere identified by linkagewith Office for National Statistics records. The associations between smoking status and smoking cessation with all-cause and causespecific mortality (circulatory disease, all cancers, lung cancer, respiratory disease, and respiratory infection) were investigated using adjusted Cox (all-causemortality) and Fine-Gray (cause-specificmortality) regression.\n\n\nResults: \n\nThe cohort comprised 5,677 patients (median age 61.4 years, 68% women), with 40% as never smokers, 34% former smokers, and 26% current smokers at baseline. Compared to never smoking, current smokingwas associated with an increased risk of all-causemortality (hazard ratio 1.98 [95% confidence interval (95% CI) 1.56, 2.53]), andmortality due to circulatory disease (subdistribution hazard ratio [SHR] 1.96 [95% CI 1.33, 2.90]) and lung cancer (SHR 23.2 [95% CI 5.15, 105]). Each year of smoking cessation was associated with a decreased risk of all-cause mortality (former heavy smokers SHR 0.85 [95% CI 0.77, 0.94], former light smokers SHR 0.90 [95%CI 0.84, 0.97]).\n\n\nConclusion: \n\nCurrent smoking is associated with an increased risk of all-cause, cardiovascular, and lung cancermortality in patientswith RA. Each year of cessation is associated with a reduced risk of all-causemortality. This information may prove helpful in smoking cessation programs for patients with RA.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Rebecca M Joseph, Mohammad Movahedi, William G Dixon, Deborah P M Symmons, Smoking-Related Mortality in Patients With Early Rheumatoid Arthritis: A Retrospective Cohort Study Using the Clinical Practice Research Datalink. Authritis Care and Research, 68(11), 1598-1606, 2016." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:21:26.368152Z", "author": "Rebecca M Joseph, Mohammad Movahedi, William G Dixon, Deborah P M Symmons", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:21:26.368180Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1998 - 10/01/2012", "concept_information": [ { "concept_id": 1846, "concept_version_id": 4830, "concept_name": "Cardiovascular Disease - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH484", "phenotype_version_id": 968, "phenotype_name": "Cardiovascular Disease", "code_attribute_header": [ "Entity type", "Category", "Coding System (ICD-10 Read)" ], "codes": [ { "code": "323..00", "description": "ECG: myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "323Z.00", "description": "ECG: myocardial infarct NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30..00", "description": "Acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G301.00", "description": "Other specified anterior myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30..12", "description": "Coronary thrombosis", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30..13", "description": "Cardiac rupture following myocardial infarction (MI)", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30..15", "description": "MI - acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30..17", "description": "Silent myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G301z00", "description": "Anterior myocardial infarction NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G304.00", "description": "Posterior myocardial infarction NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G305.00", "description": "Lateral myocardial infarction NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G306.00", "description": "True posterior myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G307100", "description": "Acute non-ST segment elevation myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G308.00", "description": "Inferior myocardial infarction NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30B.00", "description": "Acute posterolateral myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30X.00", "description": "Acute transmural myocardial infarction of unspecif site", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30X000", "description": "Acute ST segment elevation myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30y.00", "description": "Other acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30yz00", "description": "Other acute myocardial infarction NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G30z.00", "description": "Acute myocardial infarction NOS", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G311000", "description": "Myocardial infarction aborted", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G311011", "description": "MI - myocardial infarction aborted", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G311500", "description": "Acute coronary syndrome", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G35..00", "description": "Subsequent myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G350.00", "description": "Subsequent myocardial infarction of anterior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G351.00", "description": "Subsequent myocardial infarction of inferior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G353.00", "description": "Subsequent myocardial infarction of other sites", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G35X.00", "description": "Subsequent myocardial infarction of unspecified site", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G38..00", "description": "Postoperative myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G380.00", "description": "Postoperative transmural myocardial infarction anterior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G381.00", "description": "Postoperative transmural myocardial infarction inferior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G384.00", "description": "Postoperative subendocardial myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G38z.00", "description": "Postoperative myocardial infarction, unspecified", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G61..12", "description": "Stroke due to intracerebral haemorrhage", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G64..13", "description": "Stroke due to cerebral arterial occlusion", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G66..00", "description": "Stroke and cerebrovascular accident unspecified", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G66..12", "description": "Stroke unspecified", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "Gyu3400", "description": "[X]Acute transmural myocardial infarction of unspecif site", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } } ] }, { "concept_id": 1847, "concept_version_id": 4832, "concept_name": "Cardiovascular Disease - Primary Care", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH484", "phenotype_version_id": 968, "phenotype_name": "Cardiovascular Disease", "code_attribute_header": [ "Entity type", "Category", "Coding System (ICD-10 Read)" ], "codes": [ { "code": "I21", "description": "Acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I21.0", "description": "Acute transmural myocardial infarction of anterior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I21.1", "description": "Acute transmural myocardial infarction of inferior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I21.2", "description": "Acute transmural myocardial infarction of other sites", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I21.3", "description": "Acute transmural myocardial infarction of unspecified site", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I21.4", "description": "Acute subendocardial myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I21.9", "description": "Acute myocardial infarction, unspecified", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I22", "description": "Subsequent myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I22.0", "description": "Subsequent myocardial infarction of anterior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I22.1", "description": "Subsequent myocardial infarction of inferior wall", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I22.8", "description": "Subsequent myocardial infarction of other sites", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I22.9", "description": "Subsequent myocardial infarction of unspecified site", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23", "description": "Certain current complications following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.0", "description": "Haemopericardium as current complication following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.1", "description": "Atrial septal defect as current complication following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.2", "description": "Ventricular septal defect as current complication following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.3", "description": "Rupture of cardiac wall without haemopericardium as current complication following acute myocardial ", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.4", "description": "Rupture of chordae tendineae as current complication following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.5", "description": "Rupture of papillary muscle as current complication following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.6", "description": "Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute my", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I23.8", "description": "Other current complications following acute myocardial infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63", "description": "Cerebral infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.0", "description": "Cerebral infarction due to thrombosis of precerebral arteries", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.1", "description": "Cerebral infarction due to embolism of precerebral arteries", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.2", "description": "Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.3", "description": "Cerebral infarction due to thrombosis of cerebral arteries", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.4", "description": "Cerebral infarction due to embolism of cerebral arteries", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.5", "description": "Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.6", "description": "Cerebral infarction due to cerebral venous thrombosis, nonpyogenic", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.8", "description": "Other cerebral infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I63.9", "description": "Cerebral infarction, unspecified", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I64", "description": "Stroke, not specified as haemorrhage or infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I64.0", "description": "Stroke, not specified as haemorrhage or infarction", "attributes": { "Entity type": "res42: cardiovascular disease", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/4dnr-r359", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 968, "version_name": "Cardiovascular Disease", "version_date": "2021-10-06T16:21:26.396697Z", "is_published": true, "is_latest": true } ] } ]