[ { "phenotype_id": "PH516", "phenotype_version_id": 1032, "name": "Depression", "definition": "Data source: \n\nWe used the Clinical Practice Research Datalink (CPRD), a large primary care database that holds complete electronic patient records (including diagnoses, prescriptions and referrals) from participating family practices across the UK. A hierarchical clinical coding system (Read) is used to record the data. In July 2012, data were available for 644 practices and 13,772,992 patients. Full details of the database have been provided elsewhere.\n\n\nDiabetes cohort:\n\nWe extracted data from 1 April 2006 to 31 March 2012 and, for ease of reporting and analysing, aggregated information into six financial years. Within each year, practice inclusion eligibility was determined by a CPRD assessment algorithm, which informs on practices considered to be of research standard; therefore, our cohort of practices varied over time. For each research standard practice and year, we defined as eligible patients those who were registered with the practice for the full year and were aged 18 years or over in that year. From these patients, using relevant Read codes for type 2 diabetes (e.g. C10F.00: Type 2 diabetes mellitus) and excluding those treated with insulin within 2 years of diagnosis, we identified 246,544 patients over the study period. Diagnoses were not constrained to the study period and a relevant code prior to the study as well as during the study period would flag a patient from the respective year onwards. Data on sex, age and removal from the database due to deaths were available and complete for all patients.We extracted data on diabetes-related macrovascular (myocardial infarction, stroke, peripheral vascular disease or amputation) and microvascular (retinopathy, neuropathy, nephropathy [chronic kidney disease stages 4–5] or foot ulcer) complications as well as comorbidities (asthma, coronary heart disease, chronic kidney disease [excluded from microvascular analysis], chronic obstructive pulmonary disease, depression, dementia, severe mental illness, heart failure, hypertension, stroke [excluded from macrovascular analysis], cancer, epilepsy, osteoarthritis, osteoporosis and hypothyroidism). Although we aimed to include all conditions associated with diabetes, the choice was partially determined by the domains incentivised under the Quality and Outcomes Framework (QOF), for which accuracy of diagnosis is considered high. Information was also extracted on smoking (never smoked, current, exsmoker and missing data),BMI, HbA1c levels (%), cholesterol levels (mmol/l) and systolic/diastolic BP (mmHg). Biometric measurement data were cleaned and we calculated patient means for each year when more than one relevant record was available. Using product lists we determined prescription prevalence (at least one) for relevant medications: ACE inhibitors, acarbose, α-blockers, anticoagulants, antiplatelet agents, β-blockers, calcium-channel blockers, thiazide diuretics, loop diuretics, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide- 1 agonists, statins and other lipid-lowering drugs, meglitinides , metformin, sulfonylureas and thiazolidinediones. For approximately 60% of the practices, records were linked to Office of National Statistics (ONS) mortality data and we had access to death dates for all their patients. For these, using ICD-10 codes (www.who.int/classifications/icd/en/) we were able to estimate deathslinked to specific causes (underlying or in the top three): diabetes (E10–E16), ischaemic heart disease (I21–I22), stroke (I60–I64) or stroke excluding bleeds (excluding I63).\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, 58:505-518, 2015. " } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:23:19.214171Z", "author": "Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Matthias Pierce, Darren M. Ashcroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:23:19.214201Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/04/2006 - 31/03/2012", "concept_information": [ { "concept_id": 1892, "concept_version_id": 4922, "concept_name": "Depression - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH516", "phenotype_version_id": 1032, "phenotype_name": "Depression", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "1B17.00", "description": "Depressed", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "212S.00", "description": "Depression resolved", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "2257", "description": "O/E - depressed", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "62T1.00", "description": "Puerperal depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "9HA1.00", "description": "Removed from depression register", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001300", "description": "Presenile dementia with depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E002100", "description": "Senile dementia with depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004300", "description": "Arteriosclerotic dementia with depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112.00", "description": "Single major depressive episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112000", "description": "Single major depressive episode; unspecified", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112100", "description": "Single major depressive episode; mild", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112.11", "description": "Agitated depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112.12", "description": "Endogenous depression first episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112.13", "description": "Endogenous depression first episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112.14", "description": "Endogenous depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112200", "description": "Single major depressive episode; moderate", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112300", "description": "Single major depressive episode; severe; without psychosis", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112500", "description": "Single major depressive episode; partial or unspec remission", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112600", "description": "Single major depressive episode; in full remission", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E112z00", "description": "Single major depressive episode NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113.00", "description": "Recurrent major depressive episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113000", "description": "Recurrent major depressive episodes; unspecified", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113100", "description": "Recurrent major depressive episodes; mild", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113.11", "description": "Endogenous depression - recurrent", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113200", "description": "Recurrent major depressive episodes; moderate", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113300", "description": "Recurrent major depressive episodes; severe; no psychosis", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113500", "description": "Recurrent major depressive episodes;partial/unspec remission", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113600", "description": "Recurrent major depressive episodes; in full remission", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113700", "description": "Recurrent depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E113z00", "description": "Recurrent major depressive episode NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E118.00", "description": "Seasonal affective disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E11y200", "description": "Atypical depressive disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E11z200", "description": "Masked depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E135.00", "description": "Agitated depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E200300", "description": "Anxiety with depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E204.00", "description": "Neurotic depression reactive type", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E204.11", "description": "Postnatal depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E290.00", "description": "Brief depressive reaction", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E290z00", "description": "Brief depressive reaction NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E291.00", "description": "Prolonged depressive reaction", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E2B..00", "description": "Depressive disorder NEC", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E2B0.00", "description": "Postviral depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E2B1.00", "description": "Chronic depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32.00", "description": "[X]Depressive episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32000", "description": "[X]Mild depressive episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32100", "description": "[X]Moderate depressive episode", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32.11", "description": "[X]Single episode of depressive reaction", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32.12", "description": "[X]Single episode of psychogenic depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32.13", "description": "[X]Single episode of reactive depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32200", "description": "[X]Severe depressive episode without psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32211", "description": "[X]Single episode agitated depressn w'out psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32212", "description": "[X]Single episode major depression w'out psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32213", "description": "[X]Single episode vital depression w'out psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32400", "description": "[X]Mild depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32y00", "description": "[X]Other depressive episodes", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32y11", "description": "[X]Atypical depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32y12", "description": "[X]Single episode of masked depression NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32z00", "description": "[X]Depressive episode; unspecified", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32z11", "description": "[X]Depression NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32z12", "description": "[X]Depressive disorder NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32z13", "description": "[X]Prolonged single episode of reactive depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu32z14", "description": "[X] Reactive depression NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33.00", "description": "[X]Recurrent depressive disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33000", "description": "[X]Recurrent depressive disorder; current episode mild", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33100", "description": "[X]Recurrent depressive disorder; current episode moderate", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33.11", "description": "[X]Recurrent episodes of depressive reaction", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33.12", "description": "[X]Recurrent episodes of psychogenic depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33.13", "description": "[X]Recurrent episodes of reactive depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33.14", "description": "[X]Seasonal depressive disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33.15", "description": "[X]SAD - Seasonal affective disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33200", "description": "[X]Recurr depress disorder cur epi severe without psyc sympt", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33211", "description": "[X]Endogenous depression without psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33212", "description": "[X]Major depression; recurrent without psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33214", "description": "[X]Vital depression; recurrent without psychotic symptoms", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33400", "description": "[X]Recurrent depressive disorder; currently in remission", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33y00", "description": "[X]Other recurrent depressive disorders", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33z00", "description": "[X]Recurrent depressive disorder; unspecified", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu33z11", "description": "[X]Monopolar depression NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu34100", "description": "[X]Dysthymia", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu34111", "description": "[X]Depressive neurosis", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu34113", "description": "[X]Neurotic depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu34114", "description": "[X]Persistant anxiety depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu3y111", "description": "[X]Recurrent brief depressive episodes", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu41200", "description": "[X]Mixed anxiety and depressive disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu41211", "description": "[X]Mild anxiety depression", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu53011", "description": "[X]Postnatal depression NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu53012", "description": "[X]Postpartum depression NOS", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu92000", "description": "[X]Depressive conduct disorder", "attributes": { "Entity type": "depression", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/7vs8-n796", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1032, "version_name": "Depression", "version_date": "2021-10-06T16:23:19.237346Z", "is_published": true, "is_latest": true } ] } ]