[ { "phenotype_id": "PH540", "phenotype_version_id": 1080, "name": "Lipid Lowering Other", "definition": "Data source: \n\nWe used the Clinical Practice Research Datalink (CPRD), a large primary care database that holds complete electronic patient records (including diagnoses, prescriptions and referrals) from participating family practices across the UK. A hierarchical clinical coding system (Read) is used to record the data. In July 2012, data were available for 644 practices and 13,772,992 patients. Full details of the database have been provided elsewhere.\n\n\nDiabetes cohort:\n\nWe extracted data from 1 April 2006 to 31 March 2012 and, for ease of reporting and analysing, aggregated information into six financial years. Within each year, practice inclusion eligibility was determined by a CPRD assessment algorithm, which informs on practices considered to be of research standard; therefore, our cohort of practices varied over time. For each research standard practice and year, we defined as eligible patients those who were registered with the practice for the full year and were aged 18 years or over in that year. From these patients, using relevant Read codes for type 2 diabetes (e.g. C10F.00: Type 2 diabetes mellitus) and excluding those treated with insulin within 2 years of diagnosis, we identified 246,544 patients over the study period. Diagnoses were not constrained to the study period and a relevant code prior to the study as well as during the study period would flag a patient from the respective year onwards. Data on sex, age and removal from the database due to deaths were available and complete for all patients.We extracted data on diabetes-related macrovascular (myocardial infarction, stroke, peripheral vascular disease or amputation) and microvascular (retinopathy, neuropathy, nephropathy [chronic kidney disease stages 4–5] or foot ulcer) complications as well as comorbidities (asthma, coronary heart disease, chronic kidney disease [excluded from microvascular analysis], chronic obstructive pulmonary disease, depression, dementia, severe mental illness, heart failure, hypertension, stroke [excluded from macrovascular analysis], cancer, epilepsy, osteoarthritis, osteoporosis and hypothyroidism). Although we aimed to include all conditions associated with diabetes, the choice was partially determined by the domains incentivised under the Quality and Outcomes Framework (QOF), for which accuracy of diagnosis is considered high. Information was also extracted on smoking (never smoked, current, exsmoker and missing data),BMI, HbA1c levels (%), cholesterol levels (mmol/l) and systolic/diastolic BP (mmHg). Biometric measurement data were cleaned and we calculated patient means for each year when more than one relevant record was available. Using product lists we determined prescription prevalence (at least one) for relevant medications: ACE inhibitors, acarbose, α-blockers, anticoagulants, antiplatelet agents, β-blockers, calcium-channel blockers, thiazide diuretics, loop diuretics, dipeptidyl peptidase-4 inhibitors, glucagon-like peptide- 1 agonists, statins and other lipid-lowering drugs, meglitinides , metformin, sulfonylureas and thiazolidinediones. For approximately 60% of the practices, records were linked to Office of National Statistics (ONS) mortality data and we had access to death dates for all their patients. For these, using ICD-10 codes (www.who.int/classifications/icd/en/) we were able to estimate deathslinked to specific causes (underlying or in the top three): diabetes (E10–E16), ischaemic heart disease (I21–I22), stroke (I60–I64) or stroke excluding bleeds (excluding I63).\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study. Diabetologia, 58:505-518, 2015. " } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:24:16.665248Z", "author": "Evangelos Kontopantelis, David A Springate, David Reeves, Darren M. Aschroff, Martin Rutter, Iain Buchan, Tim Doran, Matthias Pierce, Darren M. Ashcroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:24:16.665277Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "GPRD product codes", "value": 14 } ], "event_date_range": "01/04/2006 - 31/03/2012", "concept_information": [ { "concept_id": 1930, "concept_version_id": 4998, "concept_name": "Lipid Lowering Other - Primary Care", "coding_system": { "id": 14, "name": "GPRD product codes", "description": "GPRD product codes" }, "phenotype_id": "PH540", "phenotype_version_id": 1080, "phenotype_name": "Lipid Lowering Other", "code_attribute_header": [ "Coding System (CPRD_product_code)", "Entity type", "Category" ], "codes": [ { "code": "10094", "description": "NIASPAN TITRATION PACK modified release tablet 375mg + 500mg + 750mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "11785", "description": "colestyramine powder sugar-free 4g ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "11976", "description": "NIASPAN modified release tablet 500mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1212", "description": "colestipol granules ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1214", "description": "BEZALIP mono-tablets 400mg [ROCHE]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1215", "description": "fenofibrate capsules 100mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1217", "description": "LIPANTIL MICRO 200 capsules 200mg [FOURNIER]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "12211", "description": "nicotinic acid tablets 50mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1324", "description": "BEZALIP tablets 200mg [ROCHE]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "14379", "description": "LIPANTIL MICRO capsules 67mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "14963", "description": "nicotinic acid modified release tablet 500mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1716", "description": "QUESTRAN sachets 4g [BRISTOL]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "17614", "description": "ZIMBACOL XL modified release tablet 400mg [ARCHIMEDES]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "1764", "description": "QUESTRAN LIGHT sachets 4g [BRISTOL]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "17813", "description": "nicotinic acid tablets 100mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "17824", "description": "nicotinic acid tablets 25mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "18081", "description": "COLESTID ORANGE granules [PHARMACIA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "18098", "description": "nicotinic acid modified release tablet 375mg + 500mg + 750mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "18126", "description": "nicotinic acid modified release tablet 1000mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "184", "description": "bezafibrate tablets 200mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "19938", "description": "colestipol with aspartame granules ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "2215", "description": "LOPID capsules 300mg [PFIZER]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "23153", "description": "LIPAROL XL modified release tablet 400mg [ASHBOURNE]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "23956", "description": "MAXEPA emulsion [SEVEN SEAS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "24084", "description": "COLESTYRAMINE sachets 4g [PLIVA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "2435", "description": "LIPANTIL capsules 100mg [FOURNIER]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "24583", "description": "nicotinic acid modified release tablet 750mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "2662", "description": "MAXEPA capsules 1g [SEVEN SEAS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "29213", "description": "BEZAGEN XL modified release tablet 400mg [GEN (UK)]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "29328", "description": "BEZAFIBRATE tablets 200mg [HILLCROSS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "3089", "description": "ciprofibrate tablets 100mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "31221", "description": "BEZAFIBRATE tablets 200mg [GEN (UK)]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "3159", "description": "fenofibrate capsules 200mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "31783", "description": "FENOGAL capsules 200mg [GENUS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "3204", "description": "MAXEPA liquid [SEVEN SEAS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "32110", "description": "COLESTYRAMINE sachets 4g [DOMINION]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "3318", "description": "gemfibrozil capsules 300mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "33603", "description": "FIBRAZATE XL tablets 400mg [SANDOZ]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "33944", "description": "BEZAFIBRATE tablets 200mg [TEVA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "34181", "description": "BEZAFIBRATE modified release tablet 400mg [HILLCROSS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "34201", "description": "COLESTYRAMINE sachets 4g [ACTAVIS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "34277", "description": "GEMFIBROZIL tablets 600mg [TEVA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "37266", "description": "colesevelam hydrochloride tablets 625mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "37953", "description": "CHOLESTAGEL tablets 625mg [GENZYME]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "39420", "description": "BEZALIP MONO modified release tablet 400mg [ACTAVIS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "39576", "description": "BEZALIP tablets 200mg [ACTAVIS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "4062", "description": "LOPID tablets 600mg [PFIZER]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "4067", "description": "OLBETAM capsules 250mg [PHARMACIA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "40729", "description": "TREDAPTIVE modified release tablet 1g + 20mg [M S D]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "40885", "description": "nicotinic acid with laropiprant modified release tablet 1g + 20mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "41396", "description": "FENOFIBRATE MICRO capsules 200mg [HILLCROSS]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "42801", "description": "BEZAFIBRATE XL modified release tablet 400mg [GEN (UK)]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "47935", "description": "FENOFIBRATE capsules 200mg [TEVA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "4920", "description": "fenofibrate micronised capsules 200mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "4928", "description": "LIPANTIL MICRO capsules 200mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "5216", "description": "BEZALIP MONO modified release tablet 400mg [ROCHE]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "5390", "description": "fenofibrate micronised capsules 267mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "5564", "description": "COLESTID orange sachets [PHARMACIA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "602", "description": "bezafibrate modified release tablet 400mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "6120", "description": "EZETROL tablets 10mg [M S D]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "6155", "description": "colestyramine with aspartame powder sugar-free 4g ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "6365", "description": "COLESTID granules [PHARMACIA]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "644", "description": "colestyramine powder 4g ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "653", "description": "ezetimibe tablets 10mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "6572", "description": "OMACOR capsules [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "7540", "description": "LIPANTIL MICRO capsules 267mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "7544", "description": "NIASPAN modified release tablet 750mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "7551", "description": "NIASPAN modified release tablet 1000mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "8082", "description": "gemfibrozil tablets 600mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "8104", "description": "acipimox capsules 250mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "8366", "description": "probucol tablets 250mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "8706", "description": "MODALIM tablets 100mg [SANOFI/AVE]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "8834", "description": "LURSELLE tablets 250mg [HOECHSTMAR]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "9491", "description": "fenofibrate micronised capsules 67mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "9639", "description": "fenofibrate micronised tablets 160mg ", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } }, { "code": "9716", "description": "SUPRALIP tablets 160mg [ABBOTT]", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res9: lipid_lowering_other", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/dv36-c056", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1080, "version_name": "Lipid Lowering Other", "version_date": "2021-10-06T16:24:16.695635Z", "is_published": true, "is_latest": true } ] } ]