[
  {
    "phenotype_id": "PH568",
    "phenotype_version_id": 1136,
    "name": "Thyroid Function",
    "definition": "The study period extended from 1 April 2004, the date of introduction of the incentivisation scheme, to 31 March 2012. Practices’ performance under the QOF is measured over a financial year, so we divided the study period into eight financial years (1 April to 31 March the following year). Not all 644 practices provided research standard data (as assessed by the CPRD assessment algorithm) for the whole period. Within each year, we identified practices that reliably contributed data for the whole year. Our main dataset comprised this group of practices, which varies over time. We also generated two alternative datasets with which to assess the sensitivity of our findings. For the first, we included 452 practices that were continuously active and up to standard for the whole of the study period; for the second, we selected a subsample of 50 practices that were most representative of UK practices in terms of list sizes of patients and area deprivation according to the Index of Multiple Deprivation,13 14 two of the most important predictors of QOF performance.12 15 16 In each of the three datasets, for each financial year, we defined “eligible” patients as those registered with an included practice for the full year.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Evangelos Kontopantelis, David Springate, David Reeves, Darren M Ashcroft, Jose M Valderas, Tim Doran, Withdrawing performance indicators: retrospective analysis of general practice performance under UK Quality and Outcomes Framework. BMJ, 348:g330, 2014."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:25:08.303398Z",
    "author": "Evangelos Kontopantelis, David Springate, David Reeves, Darren M Ashcroft, Jose M Valderas, Tim Doran",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:25:08.303426Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      },
      {
        "name": "OXMIS codes",
        "value": 15
      }
    ],
    "event_date_range": "01/04/2004 - 31/03/2021",
    "concept_information": [
      {
        "concept_id": 1966,
        "concept_version_id": 5070,
        "concept_name": "Thyroid Function - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH568",
        "phenotype_version_id": 1136,
        "phenotype_name": "Thyroid Function",
        "code_attribute_header": [
          "Entity type",
          "Coding System (OXMIS Read)",
          "Category"
        ],
        "codes": [
          {
            "code": "442..00",
            "description": "Thyroid hormone tests",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4421.00",
            "description": "Thyroid hormone tests normal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442..11",
            "description": "TRH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4421.11",
            "description": "Euthyroid",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442..12",
            "description": "TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442..13",
            "description": "Thyroid function tests",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442..14",
            "description": "Thyroxine binding globulin",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4422.00",
            "description": "Thyroid hormone tests high",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4423.00",
            "description": "Thyroid hormone tests low",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4424.00",
            "description": "Serum T3 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4424000",
            "description": "Serum T3 level normal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4424100",
            "description": "Serum T3 level high",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4424200",
            "description": "Serum T3 level low",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4425.00",
            "description": "Free T3 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4426.00",
            "description": "Serum T4 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4426000",
            "description": "Serum T4 level normal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4426100",
            "description": "Serum T4 level abnormal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4427.00",
            "description": "Free T4 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4428.00",
            "description": "Free thyroxine index",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "4429.00",
            "description": "Thyroxine binding globulin-TBG",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442a.00",
            "description": "Plasma total T4 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442A.00",
            "description": "TSH - thyroid stim. hormone",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442A000",
            "description": "Serum TSH level normal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442A100",
            "description": "Serum TSH level abnormal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442b.00",
            "description": "Serum total T4 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442B.00",
            "description": "TRH - thyroid release. hormone",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442c.00",
            "description": "Plasma free T4 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442C.00",
            "description": "Thyroid horm tests borderline",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442d.00",
            "description": "Serum thyroglobulin level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442D.00",
            "description": "T3 uptake test",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442D000",
            "description": "T3 uptake test normal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442D100",
            "description": "T3 uptake test abnormal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442e.00",
            "description": "Blood spot TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442E.00",
            "description": "PBI - protein bound iodine estimation",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442f.00",
            "description": "Serum total T3 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442F.00",
            "description": "T3 suppression test",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442g.00",
            "description": "Serum thyroglobulin recovery level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442G.00",
            "description": "Thyroid hormone tests abnormal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442H.00",
            "description": "Thyroid function tests normal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442I.00",
            "description": "Thyroid function tests abnormal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442J.00",
            "description": "Thyroid function test",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442K.00",
            "description": "30 minute plasma TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442L.00",
            "description": "60 minute plasma TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442M.00",
            "description": "90 minute plasma TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442N.00",
            "description": "120 minute plasma TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442O.00",
            "description": "150 minute plasma TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442P.00",
            "description": "30 minute serum TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442Q.00",
            "description": "60 minute serum TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442S.00",
            "description": "120 minute serum TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442T.00",
            "description": "150 minute serum TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442U.00",
            "description": "Serum free triiodothyronine level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442V.00",
            "description": "Serum free T4 level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442W.00",
            "description": "Serum TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442X.00",
            "description": "Plasma TSH level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442Y.00",
            "description": "Plasma free triiodothyronine level",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "442Z.00",
            "description": "Thyroid hormone tests NOS",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "R145.00",
            "description": "[D]Thyroid function test abnormal",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          },
          {
            "code": "R145z00",
            "description": "[D]Thyroid function tests abnormal NOS",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "Read",
              "Category": "diagnostic"
            }
          }
        ]
      },
      {
        "concept_id": 1967,
        "concept_version_id": 5072,
        "concept_name": "Thyroid Function - Primary Care",
        "coding_system": {
          "id": 15,
          "name": "OXMIS codes",
          "description": "OXMIS codes"
        },
        "phenotype_id": "PH568",
        "phenotype_version_id": 1136,
        "phenotype_name": "Thyroid Function",
        "code_attribute_header": [
          "Entity type",
          "Coding System (OXMIS Read)",
          "Category"
        ],
        "codes": [
          {
            "code": "L 112MA",
            "description": "SERUM TSH",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L 112MB",
            "description": "SERUM TSH NORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L 112MC",
            "description": "SERUM TSH ABNORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L 112N",
            "description": "TSH LEVEL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L 112NB",
            "description": "TSH LEVEL NORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L 112NC",
            "description": "TSH LEVEL ABNORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4000T",
            "description": "SERUM THYROXINE LEVEL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4000TE",
            "description": "THYROXINE ESTIMATION",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4021L",
            "description": "T4 LEVEL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4021LA",
            "description": "T4 LEVEL ABNORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4021LN",
            "description": "T4 LEVEL NORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4021PA",
            "description": "T4 TOXICOSIS TEST ABNORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4021PN",
            "description": "T4 TOXICOSIS TEST NORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4021PV",
            "description": "T4 TOXICOSIS TEST",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031",
            "description": "T3 UPTAKE TEST",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031AA",
            "description": "T3 UPTAKE TEST ABNORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031AN",
            "description": "T3 UPTAKE TEST NORMAL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031HS",
            "description": "T3 SERUM LEVEL INCREASED",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031LF",
            "description": "T3 FREE LEVEL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031LS",
            "description": "T3 SERUM LEVEL DECREASED",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4031NM",
            "description": "T3 LEVEL",
            "attributes": {
              "Entity type": "Thyroid_function",
              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
            "code": "L4033F",
            "description": "THYROID FUNCTION TEST",
            "attributes": {
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              "Coding System (OXMIS Read)": "OXMIS",
              "Category": "diagnostic"
            }
          },
          {
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          },
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              "Coding System (OXMIS Read)": "OXMIS",
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        ]
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    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/0n4c-pa21",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1136,
        "version_name": "Thyroid Function",
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]