[ { "phenotype_id": "PH575", "phenotype_version_id": 1150, "name": "Hypertension", "definition": "Objective: \n\nTo investigate whether there is an association between use of ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB), and risk of acute kidney injury (AKI).\n\n\nDesign: \n\nA time-updated, new-user cohort study among people initiating common antihypertensives (ACEI/ARB, beta-blockers, calcium channel blockers and thiazide diuretics) in primary care between April 1997 and March 2014.\n\n\nParticipants: \n\nAdults initiating antihypertensive drug treatment, with at least one year of registration prior to first prescription, identified from UK primary care practices contributing to the Clinical Practice Research Datalink and eligible for linkage to hospital records data from the Hospital Episode Statistics database.\n\n\nMain outcome measures: \n\nIncidence rate ratio (RR) for first episode of AKI during time exposed to ACEI/ARB compared to time unexposed, estimated using Poisson regression adjusted for age, sex, comorbidities, use of other antihypertensive drugs, and calendar period.\n\n\nResults: \n\nAmong 570,443 participants with a median follow-up of 2.8 years (IQR 0.4 to 7) there were 15,004 first cases of AKI. The overall crude rate of AKI was 6.4/1,000 person years at risk (95% CI 6.30 to 6.50) but varied from 1.63 (1.43 to 1.86) to 662.53 (538.98 to 814.40) depending on, age, comorbidities, and other prescribed drugs. The adjusted RR of AKI during time exposed to ACEI/ARB compared to time unexposed was 1.18 (95% CI 1.13 to 1.23) which was attenuated to 1.12 (95% CI 1.08 to 1.17) after adjustment for non-thiazide diuretic therapy. There was an interaction for the risk of AKI between people using loop diuretics and ACEI/ARB. For those taking loop diuretics, the adjusted RR of AKI during time exposed to ACEI/ARB compared to time unexposed was 0.99 (95% CI 0.92 to 1.06) but it was 1.18 (95% CI 1.13 to 1.24) among people not-exposed to loop diuretics (p<0.001).\n\n\nConclusions: \n\nTreatment with ACEI/ARB alone appears to be associated with a small increase in the rate of AKI which is largely seen among people with low absolute risk of AKI. Among people requiring loop diuretics, who have a high absolute risk of AKI, treatment with ACEI/ARB had no measurable association with AKI.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Kethryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaram, Laurie A Tomlinson, Renin-angiostensin system blockage and risk of acute kidney injury. 2015." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:25:30.605367Z", "author": "Kethryn E Mansfield, Dorothea Nitsch, Liam Smeeth, Krishnan Bhaskaram, Laurie A Tomlinson", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:25:30.605395Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 }, { "name": "HES Admitted Patient Care data for CPRD GOLD", "value": 9, "uid": "4bcf64a6-f404-4ef4-ae6e-172512ab5f43", "url": "https://healthdatagateway.org/en/dataset/674", "datasource_id": 674 } ], "coding_system": [ { "name": "ICD10 codes", "value": 4 }, { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/04/1997 - 31/03/2014", "concept_information": [ { "concept_id": 1978, "concept_version_id": 5094, "concept_name": "Hypertension - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH575", "phenotype_version_id": 1150, "phenotype_name": "Hypertension", "code_attribute_header": [ "Entity type", "Category", "Coding System (ICD-10 Read)" ], "codes": [ { "code": "14A2.00", "description": "h/o: hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "1JD..00", "description": "suspected hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "2126100", "description": "hypertension resolved", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "212K.00", "description": "hypertension resolved", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "246M.00", "description": "white coat hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662..12", "description": "hypertension monitoring", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "6624", "description": "borderline hyperten:yearly obs", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "6627", "description": "good hypertension control", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "6628", "description": "poor hypertension control", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "6629", "description": "hypertension:follow-up default", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662b.00", "description": "moderate hypertension control", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662c.00", "description": "hypertension six month review", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662d.00", "description": "hypertension annual review", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662F.00", "description": "hypertension treatm. started", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662G.00", "description": "hypertensive treatm.changed", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662H.00", "description": "hypertension treatm.stopped", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662O.00", "description": "on treatment for hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662P.00", "description": "hypertension monitoring", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662P000", "description": "hypertension 9 month review", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662q.00", "description": "trial reduction of antihypertensive therapy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "662r.00", "description": "trial withdrawal of antihypertensive therapy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "67H8.00", "description": "lifestyle advice regarding hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "7Q01.00", "description": "high cost hypertension drugs", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "7Q01y00", "description": "other specified high cost hypertension drugs", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "8B26.00", "description": "antihypertensive therapy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "8BL0.00", "description": "patient on maximal tolerated antihypertensive therapy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "8CR4.00", "description": "hypertension clinical management plan", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "8HT5.00", "description": "referral to hypertension clinic", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "8I3N.00", "description": "hypertension treatment refused", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9h3..00", "description": "exception reporting: hypertension quality indicators", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9h31.00", "description": "excepted from hypertension qual indicators: patient unsuit", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9h32.00", "description": "excepted from hypertension qual indicators: informed dissent", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9N03.00", "description": "seen in hypertension clinic", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9N1y200", "description": "seen in hypertension clinic", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9N4L.00", "description": "dna - did not attend hypertension clinic", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI..00", "description": "hypertension monitoring admin.", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI1.00", "description": "attends hypertension monitor.", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI..11", "description": "hypertension clinic admin.", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI2.00", "description": "refuses hypertension monitor.", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI3.00", "description": "hyperten.monitor offer default", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI4.00", "description": "hypertens.monitor.1st letter", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI5.00", "description": "hypertens.monitor 2nd letter", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI6.00", "description": "hypertens.monitor 3rd letter", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI7.00", "description": "hypertens.monitor verbal inv.", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI8.00", "description": "hypertens.monitor phone invite", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OI9.00", "description": "hypertens.monitor deleted", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OIA.00", "description": "hypertension monitor.chck done", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OIA.11", "description": "hypertension monitored", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "9OIZ.00", "description": "hypertens.monitoring admin.nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "F404200", "description": "blind hypertensive eye", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "F421300", "description": "hypertensive retinopathy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G2...00", "description": "hypertensive disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G20..00", "description": "essential hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G200.00", "description": "malignant essential hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G201.00", "description": "benign essential hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G20..11", "description": "high blood pressure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G20..12", "description": "primary hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G202.00", "description": "systolic hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G203.00", "description": "diastolic hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G20z.00", "description": "essential hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G20z.11", "description": "hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G21..00", "description": "hypertensive heart disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G210.00", "description": "malignant hypertensive heart disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G210000", "description": "malignant hypertensive heart disease without ccf", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G210100", "description": "malignant hypertensive heart disease with ccf", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G210z00", "description": "malignant hypertensive heart disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G2...11", "description": "bp - hypertensive disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G211.00", "description": "benign hypertensive heart disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G211000", "description": "benign hypertensive heart disease without ccf", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G211100", "description": "benign hypertensive heart disease with ccf", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G211z00", "description": "benign hypertensive heart disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G21z.00", "description": "hypertensive heart disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G21z000", "description": "hypertensive heart disease nos without ccf", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G21z011", "description": "cardiomegaly - hypertensive", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G21z100", "description": "hypertensive heart disease nos with ccf", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G21zz00", "description": "hypertensive heart disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G22..00", "description": "hypertensive renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G220.00", "description": "malignant hypertensive renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G221.00", "description": "benign hypertensive renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G22..11", "description": "nephrosclerosis", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G222.00", "description": "hypertensive renal disease with renal failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G22z.00", "description": "hypertensive renal disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G22z.11", "description": "renal hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G23..00", "description": "hypertensive heart and renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G230.00", "description": "malignant hypertensive heart and renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G231.00", "description": "benign hypertensive heart and renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G232.00", "description": "hypertensive heart&renal dis wth (congestive) heart failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G233.00", "description": "hypertensive heart and renal disease with renal failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G234.00", "description": "hyperten heart&renal dis+both(congestv)heart and renal fail", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G23z.00", "description": "hypertensive heart and renal disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G24..00", "description": "secondary hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G240.00", "description": "secondary malignant hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G240000", "description": "secondary malignant renovascular hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G240z00", "description": "secondary malignant hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G241.00", "description": "secondary benign hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G241000", "description": "secondary benign renovascular hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G241z00", "description": "secondary benign hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G244.00", "description": "hypertension secondary to endocrine disorders", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G24z.00", "description": "secondary hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G24z000", "description": "secondary renovascular hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G24z100", "description": "hypertension secondary to drug", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G24zz00", "description": "secondary hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G25..00", "description": "stage 1 hypertension (nice - nat ins for hth clin excl 2011)", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G25..11", "description": "stage 1 hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G26..00", "description": "severe hypertension (nat inst for health clinical ex 2011)", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G26..11", "description": "severe hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G27..00", "description": "hypertension resistant to drug therapy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G28..00", "description": "stage 2 hypertension (nice - nat ins for hth clin excl 2011)", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G2y..00", "description": "other specified hypertensive disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G2z..00", "description": "hypertensive disease nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G672.00", "description": "hypertensive encephalopathy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "G672.11", "description": "hypertensive crisis", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "Gyu2.00", "description": "[x]hypertensive diseases", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "Gyu2000", "description": "[x]other secondary hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "Gyu2100", "description": "[x]hypertension secondary to other renal disorders", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L122.00", "description": "other pre-existing hypertension in preg/childbirth/puerp", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L122000", "description": "other pre-existing hypertension in preg/childb/puerp unspec", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L122100", "description": "other pre-existing hypertension in preg/childb/puerp - deliv", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L122300", "description": "other pre-exist hypertension in preg/childb/puerp-not deliv", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L122z00", "description": "other pre-existing hypertension in preg/childb/puerp nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L127.00", "description": "pre-eclampsia or eclampsia with pre-existing hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L127z00", "description": "pre-eclampsia or eclampsia + pre-existing hypertension nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L128.00", "description": "pre-exist hypertension compl preg childbirth and puerperium", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L128000", "description": "pre-exist hyperten heart dis compl preg childbth+puerperium", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "L128200", "description": "pre-exist 2ndry hypertens comp preg childbth and puerperium", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "TJC7.00", "description": "adverse reaction to other antihypertensives", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "TJC7z00", "description": "adverse reaction to antihypertensives nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "U60C500", "description": "[x]oth antihyperten drug caus advers eff in therap use, nec", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "U60C511", "description": "[x] adverse reaction to other antihypertensives", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } }, { "code": "U60C51A", "description": "[x] adverse reaction to antihypertensives nos", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "Read" } } ] }, { "concept_id": 1979, "concept_version_id": 5096, "concept_name": "Hypertension - Primary Care", "coding_system": { "id": 4, "name": "ICD10 codes", "description": "ICD10 Codes" }, "phenotype_id": "PH575", "phenotype_version_id": 1150, "phenotype_name": "Hypertension", "code_attribute_header": [ "Entity type", "Category", "Coding System (ICD-10 Read)" ], "codes": [ { "code": "I10", "description": "essential (primary) hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I11", "description": "hypertensive heart disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I11.0", "description": "hypertensive heart disease with (congestive) heart failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I11.9", "description": "hypertensive heart disease without (congestive) heart failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I12", "description": "hypertensive renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I12.0", "description": "hypertensive renal disease with renal failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I12.9", "description": "hypertensive renal disease without renal failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I13", "description": "hypertensive heart and renal disease", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I13.0", "description": "hypertensive heart and renal disease with (congestive) heart failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I13.1", "description": "hypertensive heart and renal disease with renal failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I13.2", "description": "hypertensive heart and renal disease with both (congestive) heart failure and renal failure", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I13.9", "description": "hypertensive heart and renal disease, unspecified", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I15", "description": "secondary hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I15.0", "description": "renovascular hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I15.1", "description": "hypertension secondary to other renal disorders", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I15.2", "description": "hypertension secondary to endocrine disorders", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I15.8", "description": "other secondary hypertension", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I15.9", "description": "secondary hypertension, unspecified", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } }, { "code": "I67.4", "description": "hypertensive encephalopathy", "attributes": { "Entity type": "res30: Hypertension", "Category": "diagnostic", "Coding System (ICD-10 Read)": "ICD-10" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/vb7z-7j27", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1150, "version_name": "Hypertension", "version_date": "2021-10-06T16:25:30.640540Z", "is_published": true, "is_latest": true } ] } ]