[ { "phenotype_id": "PH579", "phenotype_version_id": 1158, "name": "Cardiovascular Disease (CVD) Risk Score", "definition": "Objective:\n\nTo quantify how a period of intense media coverage of controversy over the risk:benefit balance of statins affected their use.\n\n\nDesign:\n\nInterrupted time series analysis of prospectively collected electronic data from primary care.\n\n\nSetting:\n\nClinical Practice Research Datalink (CPRD) in the United Kingdom.\n\n\nParticipants:\n\nPatients newly eligible for or currently taking statins for primary and secondary cardiovascular disease prevention in each month in January 2011-March 2015.\n\n\nMain Outcome Measures:\n\nAdjusted odds ratios for starting/stopping taking statins after the media coverage (October 2013-March 2014).\n\n\nResults:\n\nThere was no evidence that the period of high media coverage was associated with changes in statin initiation among patients with a high recorded risk score for cardiovascular disease (primary prevention) or a recent cardiovascular event (secondary prevention) (odds ratio 0.99 (95% confidence interval 0.87 to 1.13; P=0.92) and 1.04 (0.92 to 1.18; P=0.54), respectively), though there was a decrease in the overall proportion of patients with a recorded risk score. Patients already taking statins were more likely to stop taking them for both primary and secondary prevention after the high media coverage period (1.11 (1.05 to 1.18; P<0.001) and 1.12 (1.04 to 1.21; P=0.003), respectively). Stratified analyses showed that older patients and those with a longer continuous prescription were more likely to stop taking statins after the media coverage. In post hoc analyses, the increased rates of cessation were no longer observed after six months.\n\n\nConclusions:\n\nA period of intense public discussion over the risks: benefit balance of statins, covered widely in the media, was followed by a transient rise in the proportion of people who stopped taking statins. This research highlights the potential for widely covered health stories in the lay media to impact on healthcare related behaviour.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Anthony Mathews, Emily Herret, Antonio Gassparrini, Tjeerd Van Staa, Ben Goldacre, Liam Smeeth, Krishnan Bhaskaran, Impact of statin related media coverage on use of statins interrupted time series analysis with UK primary care data. BMJ, 353(i3283),2016." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:25:45.427169Z", "author": "Anthony Mathews, Emily Herret, Antonio Gassparrini, Tjeerd Van Staa, Ben Goldacre, Liam Smeeth, Krishnan Bhaskaran", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:25:45.427196Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/2011 - 31/03/2015", "concept_information": [ { "concept_id": 1984, "concept_version_id": 5106, "concept_name": "Cardiovascular Disease (CVD) Risk Score - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH579", "phenotype_version_id": 1158, "phenotype_name": "Cardiovascular Disease (CVD) Risk Score", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "14O7.00", "description": "At risk of heart disease", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "14O7000", "description": "High risk of heart disease", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "14OF.00", "description": "Low risk of primary heart disease", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "14OG.00", "description": "Moderate risk of primary heart disease", "attributes": { "Entity type": "res46: CVD Risk 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{ "code": "388A.00", "description": "Coronary heart disease risk", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "388R.00", "description": "Framingham coronary heart disease 10 yr adjusted risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "388W.00", "description": "Joint British Societies cardiac risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "388Y.00", "description": "UKPDS 10yr coronary heart disease risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38B1000", "description": "CVD (cardiovascular disease) risk assessment by third party", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38B1.11", "description": "Cardiovascular disease risk assessment", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38D6.00", "description": "Assessing cardiovascular risk using SIGN score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38D6.11", "description": "ASSIGN score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38DF.00", "description": "QRISK cardiovascular disease 10 year risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38DP.00", "description": "QRISK2 cardiovascular disease 10 year risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38DR.00", "description": "Framingham 1991 cardiovascular disease 10 year risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "38G6.00", "description": "Joint British Societies cardiovascular disease risk score", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "662k.00", "description": "JBS cardiovascular disease risk <10% over next 10 years", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "662l.00", "description": "JBS cardiovascular disease risk 10-20% over next 10 years", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "662m.00", "description": "JBS cardiovascular disease risk >20% up to 30% ov next 10 yr", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "662n.00", "description": "JBS cardiovascular disease risk >30% over next 10 years", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "66f2.00", "description": "Cardiovascular disease high risk review", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "6A40.00", "description": "Review of patient at risk from coronary heart disease", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "8BR1.00", "description": "Cardiovascular disease risk assessment indicated", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" } }, { "code": "8CR6.00", "description": "Coronary heart disease risk clinical management plan", "attributes": { "Entity type": "res46: CVD Risk Score", "Category": "test", "Coding System (Read)": "Read" 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"Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1158, "version_name": "Cardiovascular Disease (CVD) Risk Score", "version_date": "2021-10-06T16:25:45.455951Z", "is_published": true, "is_latest": true } ] } ]