[ { "phenotype_id": "PH614", "phenotype_version_id": 1228, "name": "Psoriasis", "definition": "Study population:\n\nThe study population included patients with a first diagnosis of psoriasis between January 1, 1994 and December 31, 2009, who were 20 years or older at the time of the diagnosis. A comparison group of up to 5 controls per psoriasis patient was selected. Patients from both cohorts did not have any history of CVD or diabetes before index date (first diagnosis of psoriasis) or corresponding consulting date and, in order to capture incident not prevalent cases of psoriasis or MI, all patients had to have at least 2 years prior registration within their general practice before entry into the study cohort. The control group consisted of patients who never received a diagnostic code for psoriasis. Controls were matched to psoriasis patients by age, gender, general practice and then by calendar time (date of first diagnosis of psoriasis). Person-time under observation for each patient was calculated from the corresponding index date up to end of the study which was the earliest date of the occurrence of the MI event, transfer out of the practice or death date, end of follow-up (December 31, 2011) or if the practice was no longer up to research data quality standards set by CPRD.\n\n\nDefinition of exposure:\n\nPatients with psoriasis were included if they had their first diagnostic code for psoriasis during January 1, 1994-December 31, 2009 and received a recognised treatment for psoriasis (emollients, topical treatment, phototherapy, systemic therapy or biologics (CG153 Psoriasis: NICE guideline) (Samarasekera and Smith, 2014)). Patients were classified as having severe psoriasis once they had received a systemic treatment (acitretin, etretinate, ciclosporin, hydroxycarbamide, methotrexate, fumaric acid), phototherapy or a biologic therapy (etanercept, adalimumab, infliximab, ustekinumab, efalizumab); alternatively they were classified as mild psoriasis.\n\n\nOutcome of interest:\n\nThe outcome of interest was fatal and non-fatal incident MI events. In our main analysis, MI events were identified using Read codes in CPRD. In sensitivity analysis, we identified MI events recorded in both CPRD and national mortality records (ONS) for those patients registered in practices that provided linked data between CPRD and ONS.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah PM Symmons, Christopher EM Griffiths, Darren M. Ashcroft, Psoriasis and the risk of myocardial infarction Cohort study using the clinical practive research datalink. 2014." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:26:48.524754Z", "author": "Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah PM Symmons, Christopher EM Griffiths, Darren M Ashcroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:26:48.524783Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1994 - 31/12/2009", "concept_information": [ { "concept_id": 2020, "concept_version_id": 5178, "concept_name": "Psoriasis - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH614", "phenotype_version_id": 1228, "phenotype_name": "Psoriasis", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "M16..00", "description": "Psoriasis and similar disorders", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161.00", "description": "Other psoriasis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161000", "description": "Psoriasis unspecified", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161100", "description": "Psoriasis annularis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161200", "description": "Psoriasis circinata", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161300", "description": "Psoriasis diffusa", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161400", "description": "Psoriasis discoidea", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161500", "description": "Psoriasis geographica", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161600", "description": "Guttate psoriasis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161700", "description": "Psoriasis gyrata", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161800", "description": "Psoriasis inveterata", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161900", "description": "Psoriasis ostracea", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161A00", "description": "Psoriasis palmaris", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161B00", "description": "Psoriasis plantaris", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161C00", "description": "Psoriasis punctata", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161E00", "description": "Psoriasis universalis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161F00", "description": "Psoriasis vulgaris", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161F11", "description": "Chronic large plaque psoriasis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161H00", "description": "Erythrodermic psoriasis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161z00", "description": "Psoriasis NOS", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16y.00", "description": "Other psoriasis and similar disorders", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16y000", "description": "Scalp psoriasis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16z.00", "description": "Psoriasis and similar disorders NOS", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Myu3000", "description": "[X]Other psoriasis", "attributes": { "Entity type": "psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/h38f-7289", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1228, "version_name": "Psoriasis", "version_date": "2021-10-06T16:26:48.552868Z", "is_published": true, "is_latest": true } ] } ]