[ { "phenotype_id": "PH688", "phenotype_version_id": 1376, "name": "Metformin (P8)", "definition": "Study question:\n\nWhat is the prevalence of different types of potentially hazardous prescribing in general practice in the United Kingdom, and what is the variation between practices?\n\n\nMethods:\n\nA cross sectional study included all adult patients potentially at risk of a prescribing or monitoring error defined by a combination of diagnoses and prescriptions in 526 general practices contributing to the Clinical Practice Research Datalink (CPRD) up to 1 April 2013. Primary outcomes were the prevalence of potentially hazardous prescriptions of anticoagulants, anti-platelets, NSAIDs, β blockers, glitazones, metformin, digoxin, antipsychotics, combined hormonal contraceptives, and oestrogens and monitoring by blood test less frequently than recommended for patients with repeated prescriptions of angiotensin converting enzyme inhibitors and loop diuretics, amiodarone, methotrexate, lithium, or warfarin.\n\n\nStudy answer and limitations:\n\n49 927 of 949 552 patients at risk triggered at least one prescribing indicator (5.26%, 95% confidence interval 5.21% to 5.30%) and 21 501 of 182 721 (11.8%, 11.6% to 11.9%) triggered at least one monitoring indicator. The prevalence of different types of potentially hazardous prescribing ranged from almost zero to 10.2%, and for inadequate monitoring ranged from 10.4% to 41.9%. Older patients and those prescribed multiple repeat medications had significantly higher risks of triggering a prescribing indicator whereas younger patients with fewer repeat prescriptions had significantly higher risk of triggering a monitoring indicator. There was high variation between practices for some indicators. Though prescribing safety indicators describe prescribing patterns that can increase the risk of harm to the patient and should generally be avoided, there will always be exceptions where the indicator is clinically justified. Furthermore there is the possibility that some information is not captured by CPRD for some practices—for example, INR results in patients receiving warfarin.\n\n\nWhat this study adds:\n\nThe high prevalence for certain indicators emphasises existing prescribing risks and the need for their appropriate consideration within primary care, particularly for older patients and those taking multiple medications. The high variation between practices indicates potential for improvement through targeted practice level intervention.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "S Jill Stocks, Evangelos Kontopantelis, Artur Akbarov, Sarah Rodgers, Anthony J Avery, Darren M Ashcroft, Examining variations in prescribing safety in UK general practice cross sectional study using the Clinical Practice Research Datalink. BMJ, 351(h5501), 2015." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:30:15.206308Z", "author": "S Jill Stocks, Evangelos Kontopantelis, Artur Akbarov, Sarah Rodgers, Anthony J Avery, Darren M Aschroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:30:15.206337Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "GPRD product codes", "value": 14 } ], "event_date_range": "Start - 01/02/2013", "concept_information": [ { "concept_id": 2108, "concept_version_id": 5354, "concept_name": "Metformin (P8) - Primary Care", "coding_system": { "id": 14, "name": "GPRD product codes", "description": "GPRD product codes" }, "phenotype_id": "PH688", "phenotype_version_id": 1376, "phenotype_name": "Metformin (P8)", "code_attribute_header": [ "Coding System (CPRD_product_code)", "Entity type", "Category" ], "codes": [ { "code": "11601", "description": "Rosiglitazone 2mg / Metformin 500mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11604", "description": "Rosiglitazone 1mg / Metformin 500mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11609", "description": "Metformin with rosiglitazone 500mg + 1mg Tablet", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11610", "description": "Metformin with rosiglitazone 500mg + 2mg Tablet", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11717", "description": "Rosiglitazone 2mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11737", "description": "Metformin with rosiglitazone 1000mg + 4mg Tablet", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11760", "description": "Metformin with rosiglitazone 1000mg + 2mg Tablet", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "11990", "description": "Metformin 500mg/5ml oral solution sugar free", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "14164", "description": "Avandamet 2mg/1000mg tablets (GlaxoSmithKline UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "16044", "description": "Glucophage SR 500mg tablets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "17580", "description": "Avandamet 1mg/500mg tablets (GlaxoSmithKline UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "18220", "description": "Pioglitazone 15mg / Metformin 850mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "23", "description": "Metformin 500mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "25678", "description": "Glucamet 500mg Tablet (Opus Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "26258", "description": "Glucamet 850mg Tablet (Opus Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "27501", "description": "Orabet 500mg Tablet (Lagap)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "30316", "description": "Metformin with pioglitazone 850mg + 15mg Tablet", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "31077", "description": "Competact 15mg/850mg tablets (Takeda UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "31146", "description": "Metsol 500mg/5ml oral solution (Kappin Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "33087", "description": "Metformin 500mg tablets (Actavis UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "33674", "description": "Metformin 850mg tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34004", "description": "Metformin 500mg tablets (IVAX Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34020", "description": "Metformin 850mg tablets (IVAX Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34135", "description": "Metformin 500mg Tablet (M & A Pharmachem Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34323", "description": "Metformin 500mg tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34504", "description": "Metformin 500mg tablets (Wockhardt UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34598", "description": "Metformin 500mg tablets (Generics (UK) Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34697", "description": "Metformin 850mg tablets (Wockhardt UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34742", "description": "Metformin 850mg tablets (Teva UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34836", "description": "Metformin 850mg tablets (Actavis UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "34917", "description": "Metformin 500mg tablets (Teva UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "37874", "description": "Vildagliptin 50mg / Metformin 850mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "37902", "description": "Vildagliptin 50mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "38355", "description": "Metformin 750mg modified-release tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "38400", "description": "Glucophage SR 750mg tablets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "38551", "description": "Eucreas 50mg/1000mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "39203", "description": "Eucreas 50mg/850mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "39560", "description": "Bolamyn SR 500mg tablets (Teva UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "39598", "description": "Metformin 1g modified-release tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "39729", "description": "Glucophage SR 1000mg tablets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "39988", "description": "Metformin 500mg oral powder sachets sugar free", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "40007", "description": "Glucophage 1000mg oral powder sachets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "40110", "description": "Glucophage 500mg oral powder sachets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "40233", "description": "Metformin 1g oral powder sachets sugar free", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "42161", "description": "Orabet 500mg Tablet (Sandoz Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "43270", "description": "Metformin 500mg/5ml oral solution sugar free (Rosemont Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "43619", "description": "Metformin 1g / Sitagliptin 50mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "43684", "description": "Janumet 50mg/1000mg tablets (Merck Sharp & Dohme Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "44250", "description": "Metformin 500mg/5ml Oral solution (Hillcross Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "45581", "description": "Metabet SR 500mg tablets (Morningside Healthcare Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "46989", "description": "Metabet SR 1000mg tablets (Morningside Healthcare Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "47939", "description": "Glucient SR 500mg tablets (Consilient Health Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "48149", "description": "Metformin 500mg tablets (Almus Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "49502", "description": "Glucophage SR 500mg tablets (Mawdsley-Brooks & Company Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "49738", "description": "Metformin 1g modified-release tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "50570", "description": "Glucophage SR 500mg tablets (Lexon (UK) Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "50821", "description": "Metformin 850mg tablets (Pfizer Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "50970", "description": "Metformin 500mg tablets (Bristol Laboratories Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "51080", "description": "Metabet SR 1000mg tablets (Actavis UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "51135", "description": "Metformin 500mg modified-release tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "51527", "description": "Metformin 500mg tablets (Boston Healthcare Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "52221", "description": "Diagemet XL 500mg tablets (Thornton & Ross Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "52442", "description": "Metformin 500mg tablets (Pfizer Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "52634", "description": "Glucophage SR 500mg tablets (DE Pharmaceuticals)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "53478", "description": "Metformin 500mg modified-release tablets (Kent Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "53774", "description": "Metabet SR 500mg tablets (Actavis UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "53867", "description": "Metformin 500mg tablets (Zentiva)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "54150", "description": "Jentadueto 2.5mg/850mg tablets (Boehringer Ingelheim Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "54442", "description": "Metformin (roi) 1000mg Tablet", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "54891", "description": "Saxagliptin 2.5mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "54898", "description": "Metformin 850mg tablets (Almus Pharmaceuticals Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "55270", "description": "Duformin 500mg Tablet (Dumex Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "55711", "description": "Metformin 500mg tablets (Alliance Healthcare (Distribution) Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "55739", "description": "Metformin 500mg tablets (Tillomed Laboratories Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "56965", "description": "Komboglyze 2.5mg/1000mg tablets (AstraZeneca UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "57147", "description": "Bolamyn SR 1000mg tablets (Teva UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "57457", "description": "Metformin 500mg tablets (Aurobindo Pharma Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "58051", "description": "Metformin 500mg/5ml oral solution", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "58607", "description": "Metformin 500mg/5ml oral solution sugar free (Zentiva)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "59620", "description": "Glucophage SR 500mg tablets (Waymade Healthcare Plc)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "60012", "description": "Dapagliflozin 5mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "60074", "description": "Metformin 1g modified-release tablets (Waymade Healthcare Plc)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "60286", "description": "Metformin 500mg/5ml oral suspension", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "60643", "description": "Xigduo 5mg/1000mg tablets (AstraZeneca UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "6855", "description": "Avandamet 2mg/500mg tablets (GlaxoSmithKline UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "7048", "description": "Metformin 500mg modified-release tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "7166", "description": "Glucophage 500mg tablets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "7325", "description": "Avandamet 4mg/1000mg tablets (GlaxoSmithKline UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "735", "description": "Metformin 100mg/ml Oral solution", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "7375", "description": "Rosiglitazone 4mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "7610", "description": "Glucophage 850mg tablets (Merck Serono Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } }, { "code": "93", "description": "Metformin 850mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res25: P8_metformin", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/vgcw-jp13", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1376, "version_name": "Metformin (P8)", "version_date": "2021-10-06T16:30:15.234089Z", "is_published": true, "is_latest": true } ] } ]