[ { "phenotype_id": "PH695", "phenotype_version_id": 1390, "name": "Anxiolitics", "definition": "Background:\n\nLittle is known about the precursors of suicide risk among primary-care patients. This study aimed to examine suicide risk in relation to patterns of clinical consultation, psychotropic drug prescribing, and psychiatric diagnoses.\n\n\nMethod: \n\nNested case-control study in the Clinical Practice Research Datalink (CPRD), England. Patients aged516 years who died by suicide during 2002–2011 (N = 2384) were matched on gender, age and practice with up to 20 living control patients (N = 46 899).\n\n\nResults: \n\nRisk was raised among non-consulting patients, and increased sharply with rising number of consultations in the preceding year [512 consultations v. 1: unadjusted odds ratio (OR) 6.0, 95% confidence interval (CI) 4.9–7.3]. Markedly elevated risk was also associated with the prescribing of multiple psychotropic medication types (55 types v. 0: OR 62.6, CI 44.3–88.4) and with having several psychiatric diagnoses (54 diagnoses v. 0: OR 31.1, CI 19.3–50.1). Risk was also raised among patients living in more socially deprived localities. The confounding effect of multiple psychotropic drug types largely accounted for the rising risk gradient observed with increasing consultation frequency.\n\n\nConclusions: \n\nA greater proportion of patients with several psychiatric diagnoses, those prescribed multiple psychotropic medication types, and those who consult at very high frequency might be considered for referral to mental health services by their general practitioners. Non-consulters are also at increased risk, which suggests that conventional models of primary care may not be effective in meeting the needs of all people in the community experiencing major psychosocial difficulties.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "K Windfuhr, D While, N Kapur, D M Ashcroft, E Kontopantelis, M J Carr, J Shaw, L Appleby, R T Webb, Suicide risk linked with clinical consultation frequency, psychiatric diagnoses and psychotropic medication prescribing in a national study of primary-care patients. Psychological Medicine, 46, 3407-3417, 2016." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:30:30.285027Z", "author": "K Windfuhr, D While, N Kapur, D M Ashcroft, E Kontopantelis, M J Carr, J Shaw, L Applyby, R T Webb", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:30:30.285057Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Multilex codes", "value": 16 } ], "event_date_range": "01/01/2002 - 31/12/2011", "concept_information": [ { "concept_id": 2115, "concept_version_id": 5368, "concept_name": "Anxiolitics - Primary Care", "coding_system": { "id": 16, "name": "Multilex codes", "description": "Multilex codes" }, "phenotype_id": "PH695", "phenotype_version_id": 1390, "phenotype_name": "Anxiolitics", "code_attribute_header": [ "Entity type", "Coding System (Multilex)", "Category" ], "codes": [ { "code": "39801020", "description": "Zimovane 7.5mg tablets (Lexon (UK) Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "479021", "description": "Zopiclone 3.75mg/5ml oral solution", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59209020", "description": "Zopiclone 7.5mg tablets (Actavis UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59210020", "description": "Zopiclone 3.75mg tablets (Actavis UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59236020", "description": "Zopiclone 3.75mg tablets (IVAX Pharmaceuticals UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59237020", "description": "Zopiclone 7.5mg tablets (IVAX Pharmaceuticals UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59593020", "description": "Zopiclone 3.75mg tablets (Teva UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59594020", "description": "Zopiclone 7.5mg tablets (Teva UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59784020", "description": "Zopiclone 7.5mg tablets (Generics (UK) Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "59785020", "description": "Zopiclone 3.75mg tablets (Generics (UK) Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "60509020", "description": "Zopiclone 3.75mg tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "60510020", "description": "Zopiclone 7.5mg tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "62715020", "description": "Zopiclone 7.5mg tablets (Sandoz Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "63436020", "description": "Zopiclone 7.5mg tablets (Kent Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "63765020", "description": "Zopiclone 7.5mg tablets (PLIVA Pharma Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "63881020", "description": "Zolpidem 5mg Tablet (Winthrop Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "63882020", "description": "Zolpidem 10mg Tablet (Winthrop Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "64484020", "description": "Zolpidem 5mg tablets (Teva UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "64487020", "description": "Zolpidem 10mg tablets (Teva UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "64733020", "description": "Zolpidem 5mg tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "64738020", "description": "Zolpidem 10mg tablets (A A H Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "65546020", "description": "Zopiclone 3.75mg tablets (Kent Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "65832020", "description": "Zolpidem 5mg tablets (IVAX Pharmaceuticals UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "65835020", "description": "Zolpidem 10mg tablets (IVAX Pharmaceuticals UK Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "66946020", "description": "Zolpidem 10mg tablets (Generics (UK) Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "72408020", "description": "Zimovane 7.5mg tablets (Sanofi)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "72416020", "description": "Zopiclone 7.5mg tablets", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "72417020", "description": "Zopiclone 3.75mg tablets", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "75692020", "description": "Zolpidem 5mg tablets", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "75693020", "description": "Zolpidem 10mg tablets", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "75696020", "description": "Stilnoct 5mg tablets (Sanofi)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "75697020", "description": "Stilnoct 10mg tablets (Sanofi)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "83069020", "description": "Zimovane LS 3.75mg tablets (Sanofi)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "85821020", "description": "Zileze 3.75 tablets (Opus Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "85822020", "description": "Zileze 7.5 tablets (Opus Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "86240020", "description": "Zaleplon 5mg capsules", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "86241020", "description": "Zaleplon 10mg capsules", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "86243020", "description": "Sonata 5mg capsules (Meda Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "86244020", "description": "Sonata 10mg capsules (Meda Pharmaceuticals Ltd)", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "91009020", "description": "Zopiclone 3.75mg/5ml oral suspension", "attributes": { "Entity type": "res38: Anxiolitics", "Coding System (Multilex)": "Multilex", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/nnfv-3g20", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1390, "version_name": "Anxiolitics", "version_date": "2021-10-06T16:30:30.308283Z", "is_published": true, "is_latest": true } ] } ]