[ { "phenotype_id": "PH699", "phenotype_version_id": 1398, "name": "Depot APDs", "definition": "Background:\n\nLittle is known about the precursors of suicide risk among primary-care patients. This study aimed to examine suicide risk in relation to patterns of clinical consultation, psychotropic drug prescribing, and psychiatric diagnoses.\n\n\nMethod: \n\nNested case-control study in the Clinical Practice Research Datalink (CPRD), England. Patients aged516 years who died by suicide during 2002–2011 (N = 2384) were matched on gender, age and practice with up to 20 living control patients (N = 46 899).\n\n\nResults: \n\nRisk was raised among non-consulting patients, and increased sharply with rising number of consultations in the preceding year [512 consultations v. 1: unadjusted odds ratio (OR) 6.0, 95% confidence interval (CI) 4.9–7.3]. Markedly elevated risk was also associated with the prescribing of multiple psychotropic medication types (55 types v. 0: OR 62.6, CI 44.3–88.4) and with having several psychiatric diagnoses (54 diagnoses v. 0: OR 31.1, CI 19.3–50.1). Risk was also raised among patients living in more socially deprived localities. The confounding effect of multiple psychotropic drug types largely accounted for the rising risk gradient observed with increasing consultation frequency.\n\n\nConclusions: \n\nA greater proportion of patients with several psychiatric diagnoses, those prescribed multiple psychotropic medication types, and those who consult at very high frequency might be considered for referral to mental health services by their general practitioners. Non-consulters are also at increased risk, which suggests that conventional models of primary care may not be effective in meeting the needs of all people in the community experiencing major psychosocial difficulties.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "K Windfuhr, D While, N Kapur, D M Ashcroft, E Kontopantelis, M J Carr, J Shaw, L Appleby, R T Webb, Suicide risk linked with clinical consultation frequency, psychiatric diagnoses and psychotropic medication prescribing in a national study of primary-care patients. Psychological Medicine, 46, 3407-3417, 2016." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:30:39.928011Z", "author": "K Windfuhr, D While, N Kapur, D M Ashcroft, E Kontopantelis, M J Carr, J Shaw, L Applyby, R T Webb", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:30:39.928038Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Multilex codes", "value": 16 } ], "event_date_range": "01/01/2002 - 31/12/2011", "concept_information": [ { "concept_id": 2119, "concept_version_id": 5376, "concept_name": "Depot APDs - Primary Care", "coding_system": { "id": 16, "name": "Multilex codes", "description": "Multilex codes" }, "phenotype_id": "PH699", "phenotype_version_id": 1398, "phenotype_name": "Depot APDs", "code_attribute_header": [ "Entity type", "Coding System (Multilex)", "Category" ], "codes": [ { "code": "48900020", "description": "Depixol -conc 100mg/ml Injection (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "50445020", "description": "Modecate 25mg/ml Injection (Sanofi-Synthelabo Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "53027020", "description": "Clopixol 200mg/ml Oily injection (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "53030020", "description": "Depixol 20mg/ml Injection (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "53031020", "description": "Depixol 40mg/2ml solution for injection ampoules (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "53053020", "description": "Modecate concentrate 100mg/ml Injection (Sanofi-Synthelabo Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "53586020", "description": "Piportil 50mg/ml Depot injection (JHC Healthcare Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "57938020", "description": "Depixol Low Volume 200mg/1ml solution for injection ampoules (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "58509020", "description": "Haldol decanoate 50mg/1ml solution for injection ampoules (Janssen-Cilag Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "58510020", "description": "Haldol decanoate 100mg/1ml solution for injection ampoules (Janssen-Cilag Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "61027020", "description": "Fluphenazine decanoate 25mg/1ml solution for injection ampoules (Hospira UK Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "61511020", "description": "Zuclopenthixol decanoate 200mg/ml oily injection", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "61512020", "description": "Zuclopenthixol decanoate 500mg/1ml solution for injection ampoules", 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"attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "62954020", "description": "Fluphenazine decanoate 25mg/ml Injection (Antigen Pharmaceuticals)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "63123020", "description": "Haloperidol decanoate 50mg/1ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "63124020", "description": "Haloperidol decanoate 100mg/1ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "65842020", "description": "Pipotiazine palmitate 50mg/ml depot injection", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "67405020", "description": "Clopixol Conc 500mg/1ml solution for injection ampoules (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "68096020", "description": "Flupentixol 40mg/2ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "89970020", "description": "Flupentixol 50mg/0.5ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "89972020", "description": "Flupentixol 100mg/1ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "89974020", "description": "Depixol Conc 50mg/0.5ml solution for injection ampoules (Lundbeck Ltd)", "attributes": { "Entity type": "res38: 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"Clopixol 200mg/1ml solution for injection ampoules (Lundbeck Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "91981020", "description": "Pipotiazine 50mg/1ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "91985020", "description": "Pipotiazine 100mg/2ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "91987020", "description": "Piportil Depot 50mg/1ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "91989020", "description": "Piportil Depot 100mg/2ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92200020", "description": "Fluphenazine decanoate 12.5mg/0.5ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92202020", "description": "Fluphenazine decanoate 25mg/1ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92204020", "description": "Fluphenazine decanoate 50mg/2ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92206020", "description": "Modecate 12.5mg/0.5ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92208020", "description": "Modecate 25mg/1ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92210020", "description": "Modecate 50mg/2ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92212020", "description": "Fluphenazine decanoate 50mg/0.5ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92214020", "description": "Fluphenazine decanoate 100mg/1ml solution for injection ampoules", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92216020", "description": "Modecate Concentrate 50mg/0.5ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "92218020", "description": "Modecate Concentrate 100mg/1ml solution for injection ampoules (Sanofi)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "98278020", "description": "Olanzapine embonate 210mg powder and solvent for suspension for injection vials", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "98329020", "description": "Olanzapine embonate 300mg powder and solvent for suspension for injection vials", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99841020", "description": "Paliperidone 50mg/0.5ml suspension for injection pre-filled syringes", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99843020", "description": "Paliperidone 75mg/0.75ml suspension for injection pre-filled syringes", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99845020", "description": "Paliperidone 100mg/1ml suspension for injection pre-filled syringes", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99847020", "description": "Paliperidone 150mg/1.5ml suspension for injection pre-filled syringes", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99849020", "description": "Xeplion 50mg/0.5ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99851020", "description": "Xeplion 75mg/0.75ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99853020", "description": "Xeplion 100mg/1ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } }, { "code": "99855020", "description": "Xeplion 150mg/1.5ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd)", "attributes": { "Entity type": "res38: Depot APDs", "Coding System (Multilex)": "Multilex", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/qss2-5k81", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1398, "version_name": "Depot APDs", "version_date": "2021-10-06T16:30:39.957006Z", "is_published": true, "is_latest": true } ] } ]