[ { "phenotype_id": "PH7", "phenotype_version_id": 14, "name": "Psoriasis", "definition": "The study population included patients with a first diagnosis of psoriasis between 1 January 1994 and 31 December 2009, who were 20 years or older at the time of the diagnosis. A comparison group of\nup to 5 controls per psoriasis patient was selected. Patients from both cohorts did not have any history of CVD or diabetes before the index date (first diagnosis of psoriasis) or corresponding consulting date\nand, in order to capture incident not prevalent cases of psoriasis or major CV events, all patients had to have at least 2 years prior registration within their general practice before entry into the study\ncohort. The control group consisted of patients who never received a diagnostic code for psoriasis. Controls were matched to psoriasis patients by age, gender, and general practice. We assigned control\npatients the same index date as the patients with psoriasis to whom they were matched. Person-time under observation for each patient was calculated from the corresponding index date up to the end of the study, which was the earliest date of the occurrence of a major\nCV event (MI, ACS, unstable angina, or stroke), transfer out of the practice, death date, end of follow-up (31 December 2011) or when the practice was no longer up to research data quality standards set by CPRD. Patient consent was not required; all patient data contained in CPRD is anonymised.\n\n\nPatients with psoriasis were included if they had their first diagnostic code for psoriasis during 1 January 1994–31 December 2009 and received a recognized treatment for psoriasis (emollients,\ntopical treatment, phototherapy, systemic therapy, or biologics (CG153 Psoriasis: NICE guideline; Samarasekera and Smith, 2014)). Patients were classified as having severe psoriasis once they had\nreceived a systemic treatment (acitretin, etretinate, ciclosporin, hydroxycarbamide, methotrexate, and fumaric acid), phototherapy, or a biologic therapy (etanercept, adalimumab, infliximab, ustekinumab,\nand efalizumab); alternatively they were classified as mild psoriasis.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S. Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M. Ashcroft, \"Psoriasis and the Risk of Major Cardiovascular Events: Cohort Study Using the Clinical Practice Research Datalink\". Journal of Investigative Dermatology, 135(9), 2189-2197, 2015." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T15:59:07.541835Z", "author": "Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M Ashcroft", "collections": [ { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T15:59:07.541868Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "https://kclhi.org/phenoflow/workflows/github.com/phenoflow/Psoriasis---8988d470-16f1-11ef-9de4-4d4ea830ad16/blob/read-potential-cases-fhir/Psoriasis.cwl", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1994 - 31/12/2009", "concept_information": [ { "concept_id": 722, "concept_version_id": 2583, "concept_name": "Psoriasis - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH7", "phenotype_version_id": 14, "phenotype_name": "Psoriasis", "code_attribute_header": [ "coding_system", "upload_date", "entity", "list_name" ], "codes": [ { "code": "M16..00", "description": "Psoriasis and similar disorders", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161.00", "description": "Other psoriasis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161000", "description": "Psoriasis unspecified", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161100", "description": "Psoriasis annularis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161200", "description": "Psoriasis circinata", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161300", "description": "Psoriasis diffusa", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161400", "description": "Psoriasis discoidea", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161500", "description": "Psoriasis geographica", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161600", "description": "Guttate psoriasis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161700", "description": "Psoriasis gyrata", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161800", "description": "Psoriasis inveterata", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161900", "description": "Psoriasis ostracea", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161A00", "description": "Psoriasis palmaris", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161B00", "description": "Psoriasis plantaris", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161C00", "description": "Psoriasis punctata", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161E00", "description": "Psoriasis universalis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161F00", "description": "Psoriasis vulgaris", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161F11", "description": "Chronic large plaque psoriasis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161H00", "description": "Erythrodermic psoriasis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M161z00", "description": "Psoriasis NOS", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M16y.00", "description": "Other psoriasis and similar disorders", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M16y000", "description": "Scalp psoriasis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "M16z.00", "description": "Psoriasis and similar disorders NOS", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } }, { "code": "Myu3000", "description": "[X]Other psoriasis", "attributes": { "coding_system": "Read", "upload_date": "2018-04-17", "entity": "diagnostic", "list_name": "696 - res66: psoriasis" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/n3jx-3r61", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 14, "version_name": "Psoriasis", "version_date": "2021-10-06T15:59:07.568412Z", "is_published": true, "is_latest": true } ] } ]