[ { "phenotype_id": "PH719", "phenotype_version_id": 1438, "name": "Upper Gastro Intestinal Malignancy", "definition": "Methodology/ Principal Findings: \n\nDesign-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non–users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1?54 (95% CI 1.27–1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83–1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56–1.09) and 0.87 (95% CI 0.55–1.36) respectively.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Ellen Wright, Peter T Schofield, Paul Seed, Mariam Molokhia, Bisphosphonates and Risk of Upper Gastrointestinal Cancer — A Case Control Study Using the General Practice Research Database (GPRD). PLoS ONE, 7:10, 2012." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:32:16.495376Z", "author": "Ellen Wright, Peter T Schofield, Paul Seed, Mariam Molokhia", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:32:16.495405Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1995 - 31/12/2007", "concept_information": [ { "concept_id": 2139, "concept_version_id": 5416, "concept_name": "Upper Gastro Intestinal Malignancy - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH719", "phenotype_version_id": 1438, "phenotype_name": "Upper Gastro Intestinal Malignancy", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "B10..00", "description": "Malignant neoplasm of oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B100.00", "description": "Malignant neoplasm of cervical oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B101.00", "description": "Malignant neoplasm of thoracic oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B102.00", "description": "Malignant neoplasm of abdominal oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B103.00", "description": "Malignant neoplasm of upper third of oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B104.00", "description": "Malignant neoplasm of middle third of oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B105.00", "description": "Malignant neoplasm of lower third of oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B106.00", "description": "Malignant neoplasm; overlapping lesion of oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B107.00", "description": "Siewert type I adenocarcinoma", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B10y.00", "description": "Malignant neoplasm of other specified part of oesophagus", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B10z.00", "description": "Malignant neoplasm of oesophagus NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B10z.11", "description": "Oesophageal cancer", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11..00", "description": "Malignant neoplasm of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B110.00", "description": "Malignant neoplasm of cardia of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B110100", "description": "Malignant neoplasm of cardio-oesophageal junction of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B110111", "description": "Malignant neoplasm of gastro-oesophageal junction", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B110z00", "description": "Malignant neoplasm of cardia of stomach NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B111.00", "description": "Malignant neoplasm of pylorus of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B111000", "description": "Malignant neoplasm of prepylorus of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11..11", "description": "Gastric neoplasm", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B111100", "description": "Malignant neoplasm of pyloric canal of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B111z00", "description": "Malignant neoplasm of pylorus of stomach NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B112.00", "description": "Malignant neoplasm of pyloric antrum of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B113.00", "description": "Malignant neoplasm of fundus of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B114.00", "description": "Malignant neoplasm of body of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B115.00", "description": "Malignant neoplasm of lesser curve of stomach unspecified", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B116.00", "description": "Malignant neoplasm of greater curve of stomach unspecified", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B117.00", "description": "Malignant neoplasm; overlapping lesion of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B118.00", "description": "Siewert type II adenocarcinoma", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B119.00", "description": "Siewert type III adenocarcinoma", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11y.00", "description": "Malignant neoplasm of other specified site of stomach", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11y000", "description": "Malignant neoplasm of anterior wall of stomach NEC", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11y100", "description": "Malignant neoplasm of posterior wall of stomach NEC", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11yz00", "description": "Malignant neoplasm of other specified site of stomach NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "B11z.00", "description": "Malignant neoplasm of stomach NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "BB55.00", "description": "[M]Linitisplastica", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "BB5C.00", "description": "[M]Gastrinoma and carcinomas", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "BB5C000", "description": "[M]Gastrinoma NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "BB5C011", "description": "[M]G cell tumour NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "BB5C100", "description": "[M]Gastrinoma; malignant", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "BB5Cz00", "description": "[M]Gastrinoma or carcinoma NOS", "attributes": { "Entity type": "res14: Upper gastrointestinal malignancy", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/rvrs-5h60", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1438, "version_name": "Upper Gastro Intestinal Malignancy", "version_date": "2021-10-06T16:32:16.522487Z", "is_published": true, "is_latest": true } ] } ]