[
  {
    "phenotype_id": "PH721",
    "phenotype_version_id": 1442,
    "name": "AIDS",
    "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:32:18.940999Z",
    "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:32:18.941027Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/04/1997 - 31/03/2014",
    "concept_information": [
      {
        "concept_id": 2141,
        "concept_version_id": 5420,
        "concept_name": "AIDS - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH721",
        "phenotype_version_id": 1442,
        "phenotype_name": "AIDS",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "A788.00",
            "description": "Acquired immune deficiency syndrome",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788000",
            "description": "Acute human immunodeficiency virus infection",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788100",
            "description": "Asymptomatic human immunodeficiency virus infection",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788.11",
            "description": "Human immunodeficiency virus infection",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788200",
            "description": "HIV infection with persistent generalised lymphadenopathy",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788300",
            "description": "Human immunodeficiency virus with constitutional disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788400",
            "description": "Human immunodeficiency virus with neurological disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788500",
            "description": "Human immunodeficiency virus with secondary infection",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788600",
            "description": "Human immunodeficiency virus with secondary cancers",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788W00",
            "description": "HIV disease resulting in unspecified malignant neoplasm",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788X00",
            "description": "HIV disease resulting/unspcf infectious+parasitic disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788y00",
            "description": "Human immunodeficiency virus with other clinical findings",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A788z00",
            "description": "Acquired human immunodeficiency virus infection syndrome NOS",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789000",
            "description": "HIV disease resulting in mycobacterial infection",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789100",
            "description": "HIV disease resulting in cytomegaloviral disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789200",
            "description": "HIV disease resulting in candidiasis",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789300",
            "description": "HIV disease resulting in Pneumocystis carinii pneumonia",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789311",
            "description": "HIV disease resulting in Pneumocystis jirovecii pneumonia",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789400",
            "description": "HIV disease resulting in multiple infections",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789500",
            "description": "HIV disease resulting in Kaposi's sarcoma",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789511",
            "description": "HIV disease resulting in Kaposi sarcoma",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789600",
            "description": "HIV disease resulting in Burkitt's lymphoma",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789700",
            "description": "HIV dis resulting oth types of non-Hodgkin's lymphoma",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789800",
            "description": "HIV disease resulting in multiple malignant neoplasms",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789900",
            "description": "HIV disease resulting in lymphoid interstitial pneumonitis",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789A00",
            "description": "HIV disease resulting in wasting syndrome",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A789X00",
            "description": "HIV dis reslt/oth mal neopl/lymph,h'matopoetc+reltd tissu",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuC.00",
            "description": "[X]Human immunodeficiency virus disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuC100",
            "description": "[X]HIV disease resulting in other viral infections",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuC300",
            "description": "[X]HIV disease resulting in multiple infections",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuC400",
            "description": "[X]HIV disease resulting/other infectious+parasitic diseases",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuC600",
            "description": "[X]HIV disease resulting in other non-Hodgkin's lymphoma",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuCC00",
            "description": "[X]HIV disease resulting in other specified conditions",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuCD00",
            "description": "[X]Unspecified human immunodeficiency virus [HIV] disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "Eu02400",
            "description": "[X]Dementia in human immunodef virus [HIV] disease",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "L179.00",
            "description": "HIV disease complicating pregnancy childbirth puerperium",
            "attributes": {
              "Entity type": "res50: AIDS",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/815h-h280",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1442,
        "version_name": "AIDS",
        "version_date": "2021-10-06T16:32:18.962606Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]