[ { "phenotype_id": "PH727", "phenotype_version_id": 1454, "name": "Congestive Heart Disease", "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in\nadults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: Using nested case-control design in electronic health record data in England, one case with first or\nrecurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C\nvariability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied\nto determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI,\n\n\n1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability\nwas associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk\n\n\n(95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea\nusers (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users\n\n\n(P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\nConclusions: HbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:33:04.155334Z", "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:33:04.155399Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/04/1997 - 31/03/2014", "concept_information": [ { "concept_id": 2147, "concept_version_id": 5432, "concept_name": "Congestive Heart Disease - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH727", "phenotype_version_id": 1454, "phenotype_name": "Congestive Heart Disease", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "14A6.00", "description": "H/O: heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "14AM.00", "description": "H/O: Heart failure in last year", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "1O1..00", "description": "Heart failure confirmed", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "33BA.00", "description": "Impaired left ventricular function", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "585f.00", "description": "Echocardiogram shows left ventricular systolic dysfunction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "585g.00", "description": "Echocardiogram shows left ventricular diastolic dysfunction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "585k.00", "description": "Echocardiogram shows normal left ventricular function", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8B29.00", "description": "Cardiac failure therapy", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8CeC.00", "description": "Preferred place of care for next exacerbation heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8CL3.00", "description": "Heart failure care plan discussed with patient", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8CMK.00", "description": "Has heart failure management plan", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8CMW800", "description": "Heart failure clinical pathway", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8H2S.00", "description": "Admit heart failure emergency", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G232.00", "description": "Hypertensive heart&renal dis wth (congestive) heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G234.00", "description": "Hyperten heart&renal dis+both(congestv)heart and renal fail", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G575100", "description": "Sudden cardiac death, so described", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G575.11", "description": "Cardio-respiratory arrest", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G58..00", "description": "Heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580.00", "description": "Congestive heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580000", "description": "Acute congestive heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580100", "description": "Chronic congestive heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580.11", "description": "Congestive cardiac failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580.12", "description": "Right heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580.13", "description": "Right ventricular failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580.14", "description": "Biventricular failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580200", "description": "Decompensated cardiac failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580300", "description": "Compensated cardiac failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G580400", "description": "Congestive heart failure due to valvular disease", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G581.00", "description": "Left ventricular failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G581000", "description": "Acute left ventricular failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G58..11", "description": "Cardiac failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G581.13", "description": "Impaired left ventricular function", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G582.00", "description": "Acute heart failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G583.00", "description": "Heart failure with normal ejection fraction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G583.11", "description": "HFNEF - heart failure with normal ejection fraction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G583.12", "description": "Heart failure with preserved ejection fraction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G584.00", "description": "Right ventricular failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G58z.00", "description": "Heart failure NOS", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G58z.11", "description": "Weak heart", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G58z.12", "description": "Cardiac failure NOS", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G5y4z00", "description": "Post cardiac operation heart failure NOS", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G5yy900", "description": "Left ventricular systolic dysfunction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "G5yyA00", "description": "Left ventricular diastolic dysfunction", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Q48y100", "description": "Congenital cardiac failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Q490.00", "description": "Neonatal cardiac failure", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "SP11100", "description": "Cardiac insufficiency as a complication of care", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "SP11111", "description": "Heart failure as a complication of care", "attributes": { "Entity type": "res50: congestive heart disease", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/pm66-xy34", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1454, "version_name": "Congestive Heart Disease", "version_date": "2021-10-06T16:33:04.184079Z", "is_published": true, "is_latest": true } ] } ]