[ { "phenotype_id": "PH732", "phenotype_version_id": 1464, "name": "Dpp-4Inhibitors", "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:33:19.961689Z", "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:33:19.961718Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "GPRD product codes", "value": 14 } ], "event_date_range": "01/04/1997 - 31/03/2014", "concept_information": [ { "concept_id": 2152, "concept_version_id": 5442, "concept_name": "Dpp-4Inhibitors - Primary Care", "coding_system": { "id": 14, "name": "GPRD product codes", "description": "GPRD product codes" }, "phenotype_id": "PH732", "phenotype_version_id": 1464, "phenotype_name": "Dpp-4Inhibitors", "code_attribute_header": [ "Coding System (CPRD_product_code)", "Entity type", "Category" ], "codes": [ { "code": "35022", "description": "Sitagliptin 100mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "35462", "description": "Januvia 100mg tablets (Merck Sharp & Dohme Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "37874", "description": "Vildagliptin 50mg / Metformin 850mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "37875", "description": "Vildagliptin 50mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "37902", "description": "Vildagliptin 50mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "38551", "description": "Eucreas 50mg/1000mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "39149", "description": "Galvus 50mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "39203", "description": "Eucreas 50mg/850mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "41204", "description": "Saxagliptin 5mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "41431", "description": "Onglyza 5mg tablets (AstraZeneca UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "43619", "description": "Metformin 1g / Sitagliptin 50mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "43684", "description": "Janumet 50mg/1000mg tablets (Merck Sharp & Dohme Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "45775", "description": "Saxagliptin 2.5mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "45821", "description": "Onglyza 2.5mg tablets (AstraZeneca UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "46665", "description": "Linagliptin 5mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "46716", "description": "Trajenta 5mg tablets (Boehringer Ingelheim Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "48401", "description": "Sitagliptin 50mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "48533", "description": "Sitagliptin 25mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "50087", "description": "Januvia 50mg tablets (Merck Sharp & Dohme Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "50124", "description": "Januvia 25mg tablets (Merck Sharp & Dohme Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "54150", "description": "Jentadueto 2.5mg/850mg tablets (Boehringer Ingelheim Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "54891", "description": "Saxagliptin 2.5mg / Metformin 1g tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "56965", "description": "Komboglyze 2.5mg/1000mg tablets (AstraZeneca UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } }, { "code": "59809", "description": "Alogliptin 6.25mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: DPP-4 inhibitors", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/sshp-g563", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1464, "version_name": "Dpp-4Inhibitors", "version_date": "2021-10-06T16:33:19.986725Z", "is_published": true, "is_latest": true } ] } ]