[ { "phenotype_id": "PH733", "phenotype_version_id": 1466, "name": "Glinide", "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:33:21.349460Z", "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:33:21.349488Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "GPRD product codes", "value": 14 } ], "event_date_range": "01/04/1997 - 31/03/2014", "concept_information": [ { "concept_id": 2153, "concept_version_id": 5444, "concept_name": "Glinide - Primary Care", "coding_system": { "id": 14, "name": "GPRD product codes", "description": "GPRD product codes" }, "phenotype_id": "PH733", "phenotype_version_id": 1466, "phenotype_name": "Glinide", "code_attribute_header": [ "Coding System (CPRD_product_code)", "Entity type", "Category" ], "codes": [ { "code": "11316", "description": "NovoNorm 500microgram tablets (Novo Nordisk Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "11321", "description": "NovoNorm 1mg tablets (Novo Nordisk Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "11366", "description": "NovoNorm 2mg tablets (Novo Nordisk Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "11483", "description": "Nateglinide 60mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "15955", "description": "Starlix 120mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "23945", "description": "Starlix 60mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "27125", "description": "Starlix 180mg tablets (Novartis Pharmaceuticals UK Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "35561", "description": "Prandin 2mg tablets (Novo Nordisk Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "36774", "description": "Prandin 1mg tablets (Novo Nordisk Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "36948", "description": "Prandin 0.5mg tablets (Novo Nordisk Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "52203", "description": "Enyglid 0.5mg tablets (Consilient Health Ltd)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "5678", "description": "Nateglinide 120mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "5989", "description": "Nateglinide 180mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "61925", "description": "NovoNorm 500microgram tablets (Waymade Healthcare Plc)", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "9707", "description": "Repaglinide 1mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "9748", "description": "Repaglinide 2mg tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } }, { "code": "9865", "description": "Repaglinide 500microgram tablets", "attributes": { "Coding System (CPRD_product_code)": "CPRD_product_code", "Entity type": "res50: glinide", "Category": "drug" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/gmcy-f196", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1466, "version_name": "Glinide", "version_date": "2021-10-06T16:33:21.378997Z", "is_published": true, "is_latest": true } ] } ]