[ { "phenotype_id": "PH735", "phenotype_version_id": 1470, "name": "Hemiplegia and paraplegia", "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017." } ], "validation": "", "citation_requirements": "", "created": "2021-10-06T16:33:23.762064Z", "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2021-10-06T16:33:23.762092Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/04/1997 - 31/03/2014", "concept_information": [ { "concept_id": 2155, "concept_version_id": 5448, "concept_name": "Hemiplegia and paraplegia - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH735", "phenotype_version_id": 1470, "phenotype_name": "Hemiplegia and paraplegia", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "2833", "description": "O/E - hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "2835", "description": "O/E - paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F038.00", "description": "Tropical spastic paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F141.00", "description": "Hereditary spastic paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F22..00", "description": "Hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F220.00", "description": "Flaccid hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F221.00", "description": "Spastic hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F222.00", "description": "Left hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F223.00", "description": "Right hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F22z.00", "description": "Hemiplegia NOS", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F230000", "description": "Congenital paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F230.11", "description": "Paraplegia - congenital", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F231.00", "description": "Congenital hemiplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F234.00", "description": "Infantile hemiplegia NOS", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F241.00", "description": "Paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F241000", "description": "Flaccid paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F241100", "description": "Spastic paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "N231011", "description": "Massive muscular calcification associated with paraplegia", "attributes": { "Entity type": "res50: hemiplegia and paraplegia", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/3ad1-v018", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1470, "version_name": "Hemiplegia and paraplegia", "version_date": "2021-10-06T16:33:23.784295Z", "is_published": true, "is_latest": true } ] } ]