[
  {
    "phenotype_id": "PH738",
    "phenotype_version_id": 1476,
    "name": "Metformin",
    "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:33:32.388784Z",
    "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:33:32.388812Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Drug",
        "value": "3"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "GPRD product codes",
        "value": 14
      }
    ],
    "event_date_range": "01/04/1997 - 31/03/2014",
    "concept_information": [
      {
        "concept_id": 2158,
        "concept_version_id": 5454,
        "concept_name": "Metformin - Primary Care",
        "coding_system": {
          "id": 14,
          "name": "GPRD product codes",
          "description": "GPRD product codes"
        },
        "phenotype_id": "PH738",
        "phenotype_version_id": 1476,
        "phenotype_name": "Metformin",
        "code_attribute_header": [
          "Coding System (CPRD_product_code)",
          "Entity type",
          "Category"
        ],
        "codes": [
          {
            "code": "11601",
            "description": "Rosiglitazone 2mg / Metformin 500mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11604",
            "description": "Rosiglitazone 1mg / Metformin 500mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11609",
            "description": "Metformin with rosiglitazone 500mg + 1mg Tablet",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11610",
            "description": "Metformin with rosiglitazone 500mg + 2mg Tablet",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11717",
            "description": "Rosiglitazone 2mg / Metformin 1g tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11737",
            "description": "Metformin with rosiglitazone 1000mg + 4mg Tablet",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11760",
            "description": "Metformin with rosiglitazone 1000mg + 2mg Tablet",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "11990",
            "description": "Metformin 500mg/5ml oral solution sugar free",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "14164",
            "description": "Avandamet 2mg/1000mg tablets (GlaxoSmithKline UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "16044",
            "description": "Glucophage SR 500mg tablets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "17580",
            "description": "Avandamet 1mg/500mg tablets (GlaxoSmithKline UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "18220",
            "description": "Pioglitazone 15mg / Metformin 850mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "23",
            "description": "Metformin 500mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "25678",
            "description": "Glucamet 500mg Tablet (Opus Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "26258",
            "description": "Glucamet 850mg Tablet (Opus Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "27501",
            "description": "Orabet 500mg Tablet (Lagap)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "30316",
            "description": "Metformin with pioglitazone 850mg + 15mg Tablet",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "31077",
            "description": "Competact 15mg/850mg tablets (Takeda UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "31146",
            "description": "Metsol 500mg/5ml oral solution (Kappin Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "33087",
            "description": "Metformin 500mg tablets (Actavis UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "33674",
            "description": "Metformin 850mg tablets (A A H Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34004",
            "description": "Metformin 500mg tablets (IVAX Pharmaceuticals UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34020",
            "description": "Metformin 850mg tablets (IVAX Pharmaceuticals UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34135",
            "description": "Metformin 500mg Tablet (M & A Pharmachem Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34323",
            "description": "Metformin 500mg tablets (A A H Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34504",
            "description": "Metformin 500mg tablets (Wockhardt UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34598",
            "description": "Metformin 500mg tablets (Generics (UK) Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34697",
            "description": "Metformin 850mg tablets (Wockhardt UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34742",
            "description": "Metformin 850mg tablets (Teva UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34836",
            "description": "Metformin 850mg tablets (Actavis UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "34917",
            "description": "Metformin 500mg tablets (Teva UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "37874",
            "description": "Vildagliptin 50mg / Metformin 850mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "37902",
            "description": "Vildagliptin 50mg / Metformin 1g tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "38355",
            "description": "Metformin 750mg modified-release tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "38400",
            "description": "Glucophage SR 750mg tablets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "38551",
            "description": "Eucreas 50mg/1000mg tablets (Novartis Pharmaceuticals UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "39203",
            "description": "Eucreas 50mg/850mg tablets (Novartis Pharmaceuticals UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "39560",
            "description": "Bolamyn SR 500mg tablets (Teva UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "39598",
            "description": "Metformin 1g modified-release tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "39729",
            "description": "Glucophage SR 1000mg tablets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "39988",
            "description": "Metformin 500mg oral powder sachets sugar free",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "40007",
            "description": "Glucophage 1000mg oral powder sachets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "40110",
            "description": "Glucophage 500mg oral powder sachets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "40233",
            "description": "Metformin 1g oral powder sachets sugar free",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "42161",
            "description": "Orabet 500mg Tablet (Sandoz Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "43270",
            "description": "Metformin 500mg/5ml oral solution sugar free (Rosemont Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "43619",
            "description": "Metformin 1g / Sitagliptin 50mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "43684",
            "description": "Janumet 50mg/1000mg tablets (Merck Sharp & Dohme Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "44250",
            "description": "Metformin 500mg/5ml Oral solution (Hillcross Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "45581",
            "description": "Metabet SR 500mg tablets (Morningside Healthcare Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "46989",
            "description": "Metabet SR 1000mg tablets (Morningside Healthcare Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "47939",
            "description": "Glucient SR 500mg tablets (Consilient Health Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "48149",
            "description": "Metformin 500mg tablets (Almus Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "49502",
            "description": "Glucophage SR 500mg tablets (Mawdsley-Brooks & Company Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "49738",
            "description": "Metformin 1g modified-release tablets (A A H Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "50570",
            "description": "Glucophage SR 500mg tablets (Lexon (UK) Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "50682",
            "description": "Jentadueto 2.5mg/1000mg tablets (Boehringer Ingelheim Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "50821",
            "description": "Metformin 850mg tablets (Pfizer Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "50970",
            "description": "Metformin 500mg tablets (Bristol Laboratories Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "51080",
            "description": "Metabet SR 1000mg tablets (Actavis UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "51135",
            "description": "Metformin 500mg modified-release tablets (A A H Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "51527",
            "description": "Metformin 500mg tablets (Boston Healthcare Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "52221",
            "description": "Diagemet XL 500mg tablets (Thornton & Ross Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "52442",
            "description": "Metformin 500mg tablets (Pfizer Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "52445",
            "description": "Linagliptin 2.5mg / Metformin 1g tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "52449",
            "description": "Linagliptin 2.5mg / Metformin 850mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "52634",
            "description": "Glucophage SR 500mg tablets (DE Pharmaceuticals)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "53478",
            "description": "Metformin 500mg modified-release tablets (Kent Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "53774",
            "description": "Metabet SR 500mg tablets (Actavis UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "53867",
            "description": "Metformin 500mg tablets (Zentiva)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "54150",
            "description": "Jentadueto 2.5mg/850mg tablets (Boehringer Ingelheim Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "54442",
            "description": "Metformin (roi) 1000mg Tablet",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "54891",
            "description": "Saxagliptin 2.5mg / Metformin 1g tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "54898",
            "description": "Metformin 850mg tablets (Almus Pharmaceuticals Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "55270",
            "description": "Duformin 500mg Tablet (Dumex Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "55711",
            "description": "Metformin 500mg tablets (Alliance Healthcare (Distribution) Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "55739",
            "description": "Metformin 500mg tablets (Tillomed Laboratories Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "56965",
            "description": "Komboglyze 2.5mg/1000mg tablets (AstraZeneca UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "57147",
            "description": "Bolamyn SR 1000mg tablets (Teva UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "57457",
            "description": "Metformin 500mg tablets (Aurobindo Pharma Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "58051",
            "description": "Metformin 500mg/5ml oral solution",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "58607",
            "description": "Metformin 500mg/5ml oral solution sugar free (Zentiva)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "59620",
            "description": "Glucophage SR 500mg tablets (Waymade Healthcare Plc)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "60012",
            "description": "Dapagliflozin 5mg / Metformin 1g tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "60074",
            "description": "Metformin 1g modified-release tablets (Waymade Healthcare Plc)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "60286",
            "description": "Metformin 500mg/5ml oral suspension",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "60643",
            "description": "Xigduo 5mg/1000mg tablets (AstraZeneca UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "60968",
            "description": "Metformin 500mg modified-release tablets (Actavis UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "61043",
            "description": "Sukkarto SR 1000mg tablets (Morningside Healthcare Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "61559",
            "description": "Sukkarto SR 500mg tablets (Morningside Healthcare Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "62144",
            "description": "Metformin 500mg modified-release tablets (DE Pharmaceuticals)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "62265",
            "description": "Metformin 500mg modified-release tablets (Mawdsley-Brooks & Company Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "6855",
            "description": "Avandamet 2mg/500mg tablets (GlaxoSmithKline UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "7048",
            "description": "Metformin 500mg modified-release tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "7166",
            "description": "Glucophage 500mg tablets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "7325",
            "description": "Avandamet 4mg/1000mg tablets (GlaxoSmithKline UK Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "735",
            "description": "Metformin 100mg/ml Oral solution",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "7375",
            "description": "Rosiglitazone 4mg / Metformin 1g tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "7610",
            "description": "Glucophage 850mg tablets (Merck Serono Ltd)",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          },
          {
            "code": "93",
            "description": "Metformin 850mg tablets",
            "attributes": {
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Entity type": "res50: metformin",
              "Category": "drug"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/nnpt-j041",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1476,
        "version_name": "Metformin",
        "version_date": "2021-10-06T16:33:32.416729Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]