[
  {
    "phenotype_id": "PH739",
    "phenotype_version_id": 1478,
    "name": "Mild Liver Disease",
    "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:33:34.193248Z",
    "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:33:34.193276Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/04/1997 - 31/03/2014",
    "concept_information": [
      {
        "concept_id": 2159,
        "concept_version_id": 5456,
        "concept_name": "Mild Liver Disease - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH739",
        "phenotype_version_id": 1478,
        "phenotype_name": "Mild Liver Disease",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "A785200",
            "description": "Cytomegaloviral hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A916100",
            "description": "Secondary syphilitic hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A98yy11",
            "description": "Gonococcal hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A98yy13",
            "description": "Gonococcal perihepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AD05.00",
            "description": "Toxoplasma hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AE23.00",
            "description": "Sequelae of viral hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuB.00",
            "description": "[X]Viral hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuB000",
            "description": "[X]Other specified acute viral hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuB100",
            "description": "[X]Other chronic viral hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuB200",
            "description": "[X]Chronic viral hepatitis, unspecified",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "AyuJ900",
            "description": "[X]Sequelae of viral hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "C310400",
            "description": "Glycogenosis with hepatic cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "C350012",
            "description": "Pigmentary cirrhosis of liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "C370800",
            "description": "Cystic fibrosis related cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "C376100",
            "description": "Alpha-1-antitrypsin hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852200",
            "description": "Oesophageal varices in cirrhosis of the liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852300",
            "description": "Oesophageal varices in alcoholic cirrhosis of the liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J61..00",
            "description": "Cirrhosis and chronic liver disease",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J611.00",
            "description": "Acute alcoholic hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J612.00",
            "description": "Alcoholic cirrhosis of liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J612.11",
            "description": "Florid cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J612.12",
            "description": "Laennec's cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614.00",
            "description": "Chronic hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614000",
            "description": "Chronic persistent hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614100",
            "description": "Chronic active hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614111",
            "description": "Autoimmune chronic active hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614200",
            "description": "Chronic aggressive hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614300",
            "description": "Recurrent hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614400",
            "description": "Chronic lobular hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614y00",
            "description": "Chronic hepatitis unspecified",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J614z00",
            "description": "Chronic hepatitis NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615.00",
            "description": "Cirrhosis - non alcoholic",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615100",
            "description": "Multilobular portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615.11",
            "description": "Portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615300",
            "description": "Diffuse nodular cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615400",
            "description": "Fatty portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615500",
            "description": "Hypertrophic portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615600",
            "description": "Capsular portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615700",
            "description": "Cardiac portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615711",
            "description": "Congestive cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615800",
            "description": "Juvenile portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615812",
            "description": "Indian childhood cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615C00",
            "description": "Xanthomatous portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615D00",
            "description": "Bacterial portal cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615H00",
            "description": "Infectious cirrhosis NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615y00",
            "description": "Portal cirrhosis unspecified",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615z00",
            "description": "Non-alcoholic cirrhosis NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615z11",
            "description": "Macronodular cirrhosis of liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615z12",
            "description": "Cryptogenic cirrhosis of liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J615z13",
            "description": "Cirrhosis of liver NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J616.00",
            "description": "Biliary cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J616000",
            "description": "Primary biliary cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J616100",
            "description": "Secondary biliary cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J616200",
            "description": "Biliary cirrhosis of children",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J616z00",
            "description": "Biliary cirrhosis NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J617.00",
            "description": "Alcoholic hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J617000",
            "description": "Chronic alcoholic hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J61y.00",
            "description": "Other non-alcoholic chronic liver disease",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J61y300",
            "description": "Portal fibrosis without cirrhosis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J61y800",
            "description": "Nonalcoholic steatohepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J61yz00",
            "description": "Other non-alcoholic chronic liver disease NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J61z.00",
            "description": "Chronic liver disease NOS",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J633000",
            "description": "Toxic hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J635300",
            "description": "Toxic liver disease with chronic persistent hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J635400",
            "description": "Toxic liver disease with chronic lobular hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J635500",
            "description": "Toxic liver disease with chronic active hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J635600",
            "description": "Toxic liver disease with fibrosis and cirrhosis of liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J63B.00",
            "description": "Autoimmune hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J63X.00",
            "description": "Granulomatous hepatitis, not elsewhere classified",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J63y100",
            "description": "Nonspecific reactive hepatitis",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "Jyu7100",
            "description": "[X]Other and unspecified cirrhosis of liver",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "Jyu7700",
            "description": "[X]Granulomatous hepatitis, not elsewhere classified",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "L176500",
            "description": "Viral hepatitis comp pregnancy, childbirth & the puerperium",
            "attributes": {
              "Entity type": "res50: mild liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/ee9t-t498",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1478,
        "version_name": "Mild Liver Disease",
        "version_date": "2021-10-06T16:33:34.221911Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]