[
  {
    "phenotype_id": "PH740",
    "phenotype_version_id": 1480,
    "name": "Moderate or Severe Liver disease",
    "definition": "Aims: \n\nTo determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).\n\n\nMethods: \n\nUsing nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.\n\n\nResults: \n\nIn T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25–2.89) and 392% higher recurrent HH risk (95% CI, 1.17–20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88–11.08) and 573% higher recurrent HH risk (95% CI,1.59–28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P b 0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P = 0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P ≤ 0.004).\n\n\nConclusions: \n\nHbA1C variability is a strong predictor for HH in T1D and T2D.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis, HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes: A nested case-control study. Journal of Diabetes and Its Complications, 32(2), 2017."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2021-10-06T16:33:35.621966Z",
    "author": "Victor W Zhong, Juhaeri Juhaeri, Stephen R Cole, Christian M Shay, Carolyn A Chew-Graham, Penny Gordon-Larsen, Evangelos Kontopantelis, Elizabeth J Mayer-Davis",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2021-10-06T16:33:35.621993Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/04/1997 - 31/03/2014",
    "concept_information": [
      {
        "concept_id": 2160,
        "concept_version_id": 5458,
        "concept_name": "Moderate or Severe Liver disease - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH740",
        "phenotype_version_id": 1480,
        "phenotype_name": "Moderate or Severe Liver disease",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "7609",
            "description": "Open operations on oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "7609300",
            "description": "Local ligation of oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "7609400",
            "description": "Open injection sclerotherapy to oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "7609y00",
            "description": "Other specified open operation on oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "7609z00",
            "description": "Open operation on oesophageal varices NOS",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "760C300",
            "description": "Fibreoptic endoscopic injection sclerotherapy oesoph varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "760C500",
            "description": "Fibreoptic endoscopic banding of oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "760F300",
            "description": "Rigid oesophagoscopic injection sclerotherapy oesoph varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "760F400",
            "description": "Rigid oesophagoscopic banding of oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A053.00",
            "description": "Amoebic liver abscess",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "A704z00",
            "description": "Other specified viral hepatitis with hepatic coma NOS",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G850.00",
            "description": "Oesophageal varices with bleeding",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G851.00",
            "description": "Oesophageal varices without bleeding",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G85..11",
            "description": "Oesophageal varices",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852.00",
            "description": "Oesophageal varices in diseases EC",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852000",
            "description": "Oesophageal varices with bleeding in diseases EC",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852100",
            "description": "Oesophageal varices without bleeding in diseases EC",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852200",
            "description": "Oesophageal varices in cirrhosis of the liver",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852300",
            "description": "Oesophageal varices in alcoholic cirrhosis of the liver",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G852z00",
            "description": "Oesophageal varices in diseases EC NOS",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "G858.00",
            "description": "Oesophageal varices NOS",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "Gyu9400",
            "description": "[X]Oesophageal varices in diseases classified elsewhere",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J62..00",
            "description": "Liver abscess and sequelae of chronic liver disease",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J620.00",
            "description": "Liver abscess - excluding amoebic liver abscess",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J620000",
            "description": "Liver abscess due to portal pyaemia",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J620100",
            "description": "Liver abscess due to cholangitis",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J620200",
            "description": "Liver abscess via hepatic artery",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J620300",
            "description": "Liver abscess via umbilicus",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J620z00",
            "description": "Liver abscess NOS",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J622.00",
            "description": "Hepatic coma",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J623.00",
            "description": "Portal hypertension",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J624.00",
            "description": "Hepatorenal syndrome",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J62y.00",
            "description": "Other sequelae of chronic liver disease",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J62z.00",
            "description": "Liver abscess and chronic liver disease causing sequelae NOS",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "SP14300",
            "description": "Hepatorenal syndrome as a complication of care",
            "attributes": {
              "Entity type": "res50: Moderate or severe liver disease",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/g4v8-nc75",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1480,
        "version_name": "Moderate or Severe Liver disease",
        "version_date": "2021-10-06T16:33:35.650159Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]