[
  {
    "phenotype_id": "PH802",
    "phenotype_version_id": 2226,
    "name": "Empyema or pyothorax or purulent pleuritis Primary care",
    "definition": "\n- Not found code search\n- Hamilton et al, 2020Clinical coding of pleural empyema was validated using coding data from three hospitals in England, UK. The coded diagnoses of pleural empyema is defined as J86-, also known as pyothorax.  Empyema was considered as a pleural effusion that had a documented pH of less than 7.2, microscopic evidence of infection, or frank pus. If microscopic evidence was not available, then clear clinical management as empyema (supporting radiology, clinical progress, and biochemistry) was used.The clinical diagnosis of empyema was made on retrospective review of the notes, discharge summary, radiology, and microbiology available.Empyema was considered as a pleural effusion that had a documented pH of less than 7.2, microscopic evidence of infection, or frank pus. If microscopic evidence was not available, then clear clinical management as empyema (supporting radiology, clinical progress, and biochemistry) was used.Empyema coding was generally good (>85% accuracy), although some cases were miscoded. Using codes for elective admissions helped to differentiate post-operative from community acquired empyema. It is likely empyema is under rather than over-recorded in HES data.Using codes for elective admissions helped to differentiate post-operative from community acquired empyema. It is likely empyema is under rather than over-recorded in HES data.",
    "implementation": "\n\nThese codes are not intended to be mandatory, but are to be used as a starting point for the identification of empyema in routine Electronic Health Record (EHR). Each study may differ in the sensitivity and specificity of the coding required.  \n\n \n\nAccording to the National Health Service (NHS), Empyema is defined as pocketcs of pus that have collected insided a body cavity. They can form if a bacterial infection is left untreated, or if it fails to fully respond to treatment. The term is most commonly used to refer to pus-filled pockets that develop in the pleural space.\n\nhttps://www.nhs.uk/conditions/empyema/\n\nNot found code search\n\n",
    "publications": [
      {
        "doi": null,
        "details": "Publications in 2020-2021 identified in PubMed"
      },
      {
        "doi": "10.1183/13993003.03546-2020",
        "details": "Arnold DT, Hamilton FW, Morris TT, Suri T, Morley A, Frost V, Vipond IB, Medford AR, Payne RA, Muir P, Maskell NA. Epidemiology of pleural empyema in English hospitals and the impact of influenza. Eur Respir J. 2021 Jun 17;57(6):2003546. doi: 10.1183/13993003.03546-2020. PMID: 33334937."
      },
      {
        "doi": "10.1136/thoraxjnl-2020-216032",
        "details": "Strachan R, Homaira N, Beggs S, Bhuiyan MU, Gilbert GL, Lambert SB, Macartney K, Marshall H, Martin AC, McCallum GB, McCullagh A, McDonald T, McIntyre P, Oftadeh S, Ranganathan S, Suresh S, Wainwright CE, Wilson A, Wong M, Snelling T, Jaffé A. Assessing the impact of the 13 valent pneumococcal vaccine on childhood empyema in Australia. Thorax. 2021 May;76(5):487-493. doi: 10.1136/thoraxjnl-2020-216032. Epub 2021 Jan 27. PMID: 33504566."
      },
      {
        "doi": null,
        "details": ">Code repositories"
      },
      {
        "doi": null,
        "details": "**ID**- 1 \n- **Repository**- Manchester ClinicalCodes \n- **Description**- The association between smoking and hospitalisations for cardiovascular events and respiratory infection in patients with rheumatoid arthritis: a retrospective cohort study using the Clinical Practice Research Datalink \n- **Conditions**- Respiratory tract infection \n- **Publication**- Unpublished \n- **Clinical codes**- ICD-10 "
      },
      {
        "doi": "10.1002/acr.22882",
        "details": "**ID**- 2 \n- **Repository**- Manchester ClinicalCodes \n- **Description**- Smoking-related mortality in patients with early rheumatoid arthritis – a retrospective cohort study using the Clinical Practice Research Datalink \n- **Conditions**- Respiratory tract infection \n- **Publication**- https://doi.org/10.1002/acr.22882 \n- **Clinical codes**- ICD-10 "
      },
      {
        "doi": "10.1093/jac/dkz163",
        "details": "**ID**- 3 \n- **Repository**- Manchester ClinicalCodes \n- **Description**- Antibiotic prescribing for common infections in UK general practice: variability and drivers \n- **Conditions**- LRTI \n- **Publication**- https://doi.org/10.1093/jac/dkz163 \n- **Clinical codes**- Read Version 2 "
      },
      {
        "doi": null,
        "details": "**ID**- 4 \n- **Repository**- HDR UK National Phenomics Resource Project \n- **Description**-  \n- **Conditions**- Bacterial diseases (excl TB) \n- **Publication**-  \n- **Clinical codes**- ICD-10 "
      },
      {
        "doi": null,
        "details": "**ID**- 5 \n- **Repository**- HDR UK National Phenomics Resource Project \n- **Description**-  \n- **Conditions**- Lower respiratory tract infections \n- **Publication**-  \n- **Clinical codes**- ICD-10 "
      }
    ],
    "validation": "Hamilton et al, 2020Clinical coding of pleural empyema was validated using coding data from three hospitals in England, UK. The coded diagnoses of pleural empyema is defined as J86-, also known as pyothorax.  Empyema was considered as a pleural effusion that had a documented pH of less than 7.2, microscopic evidence of infection, or frank pus. If microscopic evidence was not available, then clear clinical management as empyema (supporting radiology, clinical progress, and biochemistry) was used.The clinical diagnosis of empyema was made on retrospective review of the notes, discharge summary, radiology, and microbiology available.Empyema was considered as a pleural effusion that had a documented pH of less than 7.2, microscopic evidence of infection, or frank pus. If microscopic evidence was not available, then clear clinical management as empyema (supporting radiology, clinical progress, and biochemistry) was used.Empyema coding was generally good (>85% accuracy), although some cases were miscoded. Using codes for elective admissions helped to differentiate post-operative from community acquired empyema. It is likely empyema is under rather than over-recorded in HES data.Using codes for elective admissions helped to differentiate post-operative from community acquired empyema. It is likely empyema is under rather than over-recorded in HES data.",
    "citation_requirements": "",
    "created": "2022-01-17T14:00:46.551682Z",
    "author": "Chukwuma Iwundu, Clare MacRae, Eleftheria Vasileiou",
    "collections": [
      {
        "name": "BREATHE",
        "value": 19
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 2,
    "updated": "2022-08-04T18:39:01.988145Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD Aurum",
        "value": 504,
        "uid": "1d574c14-1af0-490d-9c4e-be88cfd0e345",
        "url": "https://healthdatagateway.org/en/dataset/692",
        "datasource_id": 692
      },
      {
        "name": "Welsh Longitudinal General Practice Dataset (WLGP) - Welsh Primary Care",
        "value": 502,
        "uid": "33fc3ffd-aa4c-4a16-a32f-0c900aaea3d2",
        "url": "https://healthdatagateway.org/en/dataset/355",
        "datasource_id": 355
      },
      {
        "name": "CPRD GOLD",
        "value": 503,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      },
      {
        "name": "SNOMED  CT codes",
        "value": 9
      }
    ],
    "event_date_range": "01/01/2001 to 31/01/2021",
    "concept_information": [
      {
        "concept_id": 2504,
        "concept_version_id": 6408,
        "concept_name": "Empyema or pyothorax or purulent pleuritis Primary care -  2",
        "coding_system": {
          "id": 9,
          "name": "SNOMED  CT codes",
          "description": "SNOMED CT codes"
        },
        "phenotype_id": "PH802",
        "phenotype_version_id": 2226,
        "phenotype_name": "Empyema or pyothorax or purulent pleuritis Primary care",
        "code_attribute_header": [
          "SNOMED CT Concept ID",
          "Read v2",
          "Description",
          "BREATHE recommended"
        ],
        "codes": [
          {
            "code": "121449018",
            "description": "Empyema of gallbladder",
            "attributes": {
              "SNOMED CT Concept ID": "73125001",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "1231843013",
            "description": "Purulent pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "58554001",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "12711015",
            "description": "Streptococcal pleurisy with effusion",
            "attributes": {
              "SNOMED CT Concept ID": "7097001",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "128069014",
            "description": "Fibrinous pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "77138008",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "141587016",
            "description": "Streptococcal pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "85420008",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "141595017",
            "description": "Bacterial pleurisy with effusion",
            "attributes": {
              "SNOMED CT Concept ID": "85426002",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "2011541000006110",
            "description": "OH respiratory questionnaire: history of pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "2011541000006106",
              "Read v2": "J650.12",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "2011551000006112",
            "description": "OH respiratory questionnaire: no history of pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "2011551000006108",
              "Read v2": "H501400",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "218821000006118",
            "description": "Pleural empyema",
            "attributes": {
              "SNOMED CT Concept ID": "58554001",
              "Read v2": "H511200",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "22395010",
            "description": "Diaphragmatic pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "13082000",
              "Read v2": "H510700",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "24683016",
            "description": "Tuberculous empyema",
            "attributes": {
              "SNOMED CT Concept ID": "14527007",
              "Read v2": "H510B00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "2730071000006112",
            "description": "Tuberculous pleural empyema",
            "attributes": {
              "SNOMED CT Concept ID": "14527007",
              "Read v2": "H511.00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "286214019",
            "description": "Tuberculous pleurisy in primary progressive tuberculosis",
            "attributes": {
              "SNOMED CT Concept ID": "186172004",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "286225011",
            "description": "Tuberculous pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "186182003",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "286230010",
            "description": "Tuberculous pleurisy NOS",
            "attributes": {
              "SNOMED CT Concept ID": "186182003",
              "Read v2": "H501200",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "2990251000006110",
            "description": "Empyema necessitans",
            "attributes": {
              "SNOMED CT Concept ID": "30437004",
              "Read v2": "H510400",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "301625018",
            "description": "Empyema with pleural fistula NOS",
            "attributes": {
              "SNOMED CT Concept ID": "271503005",
              "Read v2": "A120100",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "301626017",
            "description": "Empyema with thoracic fistula NOS",
            "attributes": {
              "SNOMED CT Concept ID": "271503005",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "301635012",
            "description": "Lung empyema NOS",
            "attributes": {
              "SNOMED CT Concept ID": "58554001",
              "Read v2": "A101.00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "301647018",
            "description": "Acute dry pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "196077006",
              "Read v2": "A120.00",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "301650015",
            "description": "Basal pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "196079009",
              "Read v2": "A120z00",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "301651016",
            "description": "Chronic dry pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "196080007",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "301652011",
            "description": "Sterile pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "196081006",
              "Read v2": "H500400",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "301661011",
            "description": "Bacterial pleurisy with effusion NOS",
            "attributes": {
              "SNOMED CT Concept ID": "85426002",
              "Read v2": "H500500",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "301669013",
            "description": "Exudative pleurisy NOS",
            "attributes": {
              "SNOMED CT Concept ID": "196075003",
              "Read v2": "H501300",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "301670014",
            "description": "Serofibrinous pleurisy NOS",
            "attributes": {
              "SNOMED CT Concept ID": "196075003",
              "Read v2": "H510300",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "301671013",
            "description": "Serous pleurisy NOS",
            "attributes": {
              "SNOMED CT Concept ID": "196075003",
              "Read v2": "H510500",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "3048161000006111",
            "description": "Adhesive pleuritis",
            "attributes": {
              "SNOMED CT Concept ID": "34038005",
              "Read v2": "H510600",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "3349791000006110",
            "description": "Mastoid empyema",
            "attributes": {
              "SNOMED CT Concept ID": "52404001",
              "Read v2": "H510800",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "3451091000006115",
            "description": "Suppurative pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "58554001",
              "Read v2": "H511z00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "3451101000006114",
            "description": "Empyema thoracis",
            "attributes": {
              "SNOMED CT Concept ID": "58554001",
              "Read v2": "H51z000",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "3754521000006119",
            "description": "Fibrinous pleuritis",
            "attributes": {
              "SNOMED CT Concept ID": "77138008",
              "Read v2": "H51z100",
              "Description": "",
              "BREATHE recommended": "N"
            }
          },
          {
            "code": "3854971000006111",
            "description": "Epidemic benign dry pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "83264000",
              "Read v2": "H51z200",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "3854981000006114",
            "description": "Epidemic pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "83264000",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "39802016",
            "description": "Staphylococcal pleurisy with effusion",
            "attributes": {
              "SNOMED CT Concept ID": "23698009",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "406305010",
            "description": "Empyema with fistula",
            "attributes": {
              "SNOMED CT Concept ID": "271503005",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "40785018",
            "description": "Pneumococcal pleurisy with effusion",
            "attributes": {
              "SNOMED CT Concept ID": "24302002",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "456436010",
            "description": "Empyema",
            "attributes": {
              "SNOMED CT Concept ID": "312682007",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "46467017",
            "description": "Encysted pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "27757009",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "47025013",
            "description": "Empyema with bronchopleural fistula",
            "attributes": {
              "SNOMED CT Concept ID": "28085001",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "4740991000006119",
            "description": "Primary progressive tuberculosis with tuberculous pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "186172004",
              "Read v2": "H511100",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "4741061000006117",
            "description": "Tuberculous pleuritis",
            "attributes": {
              "SNOMED CT Concept ID": "186182003",
              "Read v2": "H500.00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "4782121000006111",
            "description": "Loculated empyema",
            "attributes": {
              "SNOMED CT Concept ID": "196067009",
              "Read v2": "H511000",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "50946012",
            "description": "Empyema with bronchocutaneous fistula",
            "attributes": {
              "SNOMED CT Concept ID": "30437004",
              "Read v2": "H50..00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "5407016",
            "description": "Pneumococcal pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "2585002",
              "Read v2": "H51y000",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "5525211000006118",
            "description": "Pleural empyema with fistula",
            "attributes": {
              "SNOMED CT Concept ID": "271503005",
              "Read v2": "H500100",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "5525221000006114",
            "description": "Pleural empyema with no fistula",
            "attributes": {
              "SNOMED CT Concept ID": "271504004",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "5525231000006112",
            "description": "Empyema of pleura without fistula",
            "attributes": {
              "SNOMED CT Concept ID": "271504004",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "57249012",
            "description": "Empyema with hepatopleural fistula",
            "attributes": {
              "SNOMED CT Concept ID": "34286007",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "6320012",
            "description": "Staphylococcal pleurisy",
            "attributes": {
              "SNOMED CT Concept ID": "3144005",
              "Read v2": "H500000",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "640711000006112",
            "description": "Empyema NOS",
            "attributes": {
              "SNOMED CT Concept ID": "312682007",
              "Read v2": "H510900",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "640771000006115",
            "description": "Empyema with fistula NOS",
            "attributes": {
              "SNOMED CT Concept ID": "271503005",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "640801000006118",
            "description": "Empyema with no fistula",
            "attributes": {
              "SNOMED CT Concept ID": "271504004",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "640811000006115",
            "description": "Empyema with no fistula NOS",
            "attributes": {
              "SNOMED CT Concept ID": "271504004",
              "Read v2": "",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "83211000006113",
            "description": "Tuberculous pleurisy, conf bacteriologically/histologically",
            "attributes": {
              "SNOMED CT Concept ID": "186200004",
              "Read v2": "H500200",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "84488013",
            "description": "Empyema with mediastinal fistula",
            "attributes": {
              "SNOMED CT Concept ID": "50694005",
              "Read v2": "H510A00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          },
          {
            "code": "8694011",
            "description": "Empyema of mastoid",
            "attributes": {
              "SNOMED CT Concept ID": "386034005",
              "Read v2": "H50z.00",
              "Description": "",
              "BREATHE recommended": "Y"
            }
          }
        ]
      },
      {
        "concept_id": 2503,
        "concept_version_id": 6406,
        "concept_name": "Empyema or pyothorax or purulent pleuritis Primary care -  1",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH802",
        "phenotype_version_id": 2226,
        "phenotype_name": "Empyema or pyothorax or purulent pleuritis Primary care",
        "code_attribute_header": [
          "CPRD GOLD Med",
          "BREATHE recommended",
          "Manchester Clinical Codes 3"
        ],
        "codes": [
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            "code": "A101.00",
            "description": "Tuberculous pleurisy in primary progressive tuberculosis",
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              "BREATHE recommended": "Y",
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          },
          {
            "code": "A120.00",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "A120100",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "A120z00",
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            "attributes": {
              "CPRD GOLD Med": "56890",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "A124600",
            "description": "Tuberculous pleurisy, conf bacteriologically/histologically",
            "attributes": {
              "CPRD GOLD Med": "35443",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "F530.12",
            "description": "Empyema of mastoid",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H50..00",
            "description": "Empyema",
            "attributes": {
              "CPRD GOLD Med": "2375",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": "Y"
            }
          },
          {
            "code": "H500.00",
            "description": "Empyema with fistula",
            "attributes": {
              "CPRD GOLD Med": "59340",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H500000",
            "description": "Empyema with bronchocutaneous fistula",
            "attributes": {
              "CPRD GOLD Med": "66856",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H500100",
            "description": "Empyema with bronchopleural fistula",
            "attributes": {
              "CPRD GOLD Med": "34651",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H500101",
            "description": "Empyema with bronchopleural fistula",
            "attributes": {
              "CPRD GOLD Med": "",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": "Y"
            }
          },
          {
            "code": "H500300",
            "description": "Empyema with mediastinal fistula",
            "attributes": {
              "CPRD GOLD Med": "113005",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H500400",
            "description": "Empyema with pleural fistula NOS",
            "attributes": {
              "CPRD GOLD Med": "99547",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H500z00",
            "description": "Empyema with fistula NOS",
            "attributes": {
              "CPRD GOLD Med": "111451",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H501.00",
            "description": "Empyema with no fistula",
            "attributes": {
              "CPRD GOLD Med": "53494",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H501200",
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              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H501201",
            "description": "Pleural empyema",
            "attributes": {
              "CPRD GOLD Med": "",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": "Y"
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          },
          {
            "code": "H501300",
            "description": "Lung empyema NOS",
            "attributes": {
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H501400",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H501401",
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              "BREATHE recommended": "Y",
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          },
          {
            "code": "H50z.00",
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              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H51..01",
            "description": "Pleurisy",
            "attributes": {
              "CPRD GOLD Med": "",
              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H510300",
            "description": "Acute dry pleurisy",
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              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H510301",
            "description": "Acute dry pleurisy",
            "attributes": {
              "CPRD GOLD Med": "",
              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H510400",
            "description": "Diaphragmatic pleurisy",
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              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H510500",
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              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H510600",
            "description": "Chronic dry pleurisy",
            "attributes": {
              "CPRD GOLD Med": "62895",
              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H510700",
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            "attributes": {
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              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H510800",
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            "attributes": {
              "CPRD GOLD Med": "67452",
              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H510900",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H510901",
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            "attributes": {
              "CPRD GOLD Med": "",
              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H510A00",
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              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H510B00",
            "description": "Streptococcal pleurisy",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H511.00",
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              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H511000",
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              "CPRD GOLD Med": "43345",
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              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H511100",
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            "attributes": {
              "CPRD GOLD Med": "93010",
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              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H511200",
            "description": "Streptococcal pleurisy with effusion",
            "attributes": {
              "CPRD GOLD Med": "108784",
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              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H511z00",
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          },
          {
            "code": "H51y000",
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              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H51z000",
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              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "H51z100",
            "description": "Serofibrinous pleurisy NOS",
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              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
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          },
          {
            "code": "H51z200",
            "description": "Serous pleurisy NOS",
            "attributes": {
              "CPRD GOLD Med": "55211",
              "BREATHE recommended": "N",
              "Manchester Clinical Codes 3": ""
            }
          },
          {
            "code": "J650.12",
            "description": "Empyema of gallbladder",
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              "BREATHE recommended": "Y",
              "Manchester Clinical Codes 3": ""
            }
          }
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        "concept_id": 2502,
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            "code": "121449018",
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            "code": "1231843013",
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          {
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          {
            "code": "24683016",
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            "code": "2990251000006110",
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            "code": "301625018",
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          {
            "code": "301661011",
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          {
            "code": "3349791000006110",
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          {
            "code": "3451091000006115",
            "description": "Suppurative pleurisy",
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          {
            "code": "3854971000006111",
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            "code": "3854981000006114",
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          {
            "code": "39802016",
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          {
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          {
            "code": "456436010",
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          },
          {
            "code": "46467017",
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            "code": "47025013",
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          },
          {
            "code": "4740991000006119",
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          {
            "code": "4741061000006117",
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            "code": "50946012",
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          },
          {
            "code": "5407016",
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          },
          {
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            "code": "5525221000006114",
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          {
            "code": "5525231000006112",
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            "attributes": {}
          },
          {
            "code": "57249012",
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            "attributes": {}
          },
          {
            "code": "6320012",
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          },
          {
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          },
          {
            "code": "640771000006115",
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          },
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          {
            "code": "83211000006113",
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          },
          {
            "code": "84488013",
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          },
          {
            "code": "8694011",
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      {
        "concept_id": 2501,
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          },
          {
            "code": "H500000",
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          },
          {
            "code": "H500100",
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          },
          {
            "code": "H500101",
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          },
          {
            "code": "H500300",
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          {
            "code": "H500400",
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          },
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            "code": "H500z00",
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          },
          {
            "code": "H501.00",
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          {
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          {
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            "code": "H501300",
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            "code": "H501400",
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          {
            "code": "H501401",
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          {
            "code": "H510900",
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          {
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          {
            "code": "H510A00",
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          {
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          {
            "code": "H511.00",
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          },
          {
            "code": "H511000",
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            "attributes": {}
          },
          {
            "code": "H511100",
            "description": "Staphylococcal pleurisy with effusion",
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          {
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          },
          {
            "code": "H511z00",
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          {
            "code": "J650.12",
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