[ { "phenotype_id": "PH835", "phenotype_version_id": 1749, "name": "Insulin", "definition": "We generated a cohort of 25 million patients from 1831 UK general practices registered with the Clinical Practice Research Datalink (CPRD) Aurum (inEngland) and CPRD GOLD (in Northern Ireland, Scotland, and Wales) databases. The cohort included 14 929 251 patients (median age 41 years [IQR 25–59]; 7 461 565 [50·0%] of whom were women), who were followed between March 1 and Dec 10, 2020. We aimed to compare: (1) the UK-wide incidence of type 2 diabetes; (2) the frequency of HbA1c testing; and (3) mortality in people with type 2 diabetes, by nation, before and after the first nationwide COVID-19 lockdown, which began in March 23, 2020 (appendix pp 1–3). There were 790 377 (5·3%) people with type 2 diabetes in the cohort (median age 67 years (IQR 57–76); 348 515 (44·1%) of whom were women).\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Matthew J Carr, Alison K Wright, Lalantha Leelarantha, Hood Thabit, Nicola Milne, Naresh Kanumilli, Darren M Ashcroft, Martin K Rutter, Impact of COVID-19 on diagnoses, monitoring, and mortality in people with type 2 diabetes in the UK. The Lancet Diabetes Endocrinology, 9, 2021." } ], "validation": "", "citation_requirements": "", "created": "2022-04-04T07:06:19.453463Z", "author": "Matthew J Carr, Alison K Wright, Lalantha Leelarantha, Hood Thabit, Nicola Milne, Naresh Kanumilli, Darren M Ashcroft, Martin K Rutter", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-04-04T07:06:19.453489Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Drug", "value": "3" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "GPRD product codes", "value": 14 } ], "event_date_range": "01/01/2010 - 29/02/2020", "concept_information": [ { "concept_id": 2592, "concept_version_id": 6597, "concept_name": "Insulin - Primary Care", "coding_system": { "id": 14, "name": "GPRD product codes", "description": "GPRD product codes" }, "phenotype_id": "PH835", "phenotype_version_id": 1749, "phenotype_name": "Insulin", "code_attribute_header": [ "Entity type", "Coding System (CPRD_product_code)", "Category" ], "codes": [ { "code": "10001", "description": "Humalog Mix50 Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Lilly and Company Ltd", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10067", "description": "Insulin biphasic aspart human pyr 30:70; 100 units/ml Injection", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10175", "description": "Insulin isophane human 100units/ml suspension for injection 1.5ml cartridges", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10184", "description": "Insulin detemir 100 iu/ml Solution for injection", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10207", "description": "Insulin isophane human 100units/ml suspension for injection 3ml cartridges", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10208", "description": "Insulatard InnoLet 100units/ml suspension for injection 3ml pre-filled pen (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10225", "description": "Lantus 100units/ml solution for injection 3ml OptiClik cartridges (Sanofi)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10229", "description": "Humulin I Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10243", "description": "Humalog Mix25 100units/ml suspension for injection 3ml cartridges (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10244", "description": "Mixtard 40 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10245", "description": "Mixtard 10 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10259", "description": "Insulin glargine 100units/ml solution for injection 10ml vials", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10264", "description": "Humalog Pen 100units/ml solution for injection 3ml pre-filled pen (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10277", "description": "Humulin M3 100units/ml suspension for injection 3ml cartridges (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10484", "description": "Penmix 20/80 Penfill (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10545", "description": "INSULIN HUMULIN M4 CARTRIDGE 100 I/U", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10546", "description": "INSULIN HUMULIN M4 100 I/U INJ", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10547", "description": "Humulin Lente 100units/ml suspension for injection 10ml vials (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "10566", "description": "INSULIN HUMULIN M 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"CPRD_product_code", "Category": "drug" } }, { "code": "11107", "description": "Humulin m4 100unit/ml M4 injection (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "11337", "description": "NovoRapid Novolet 100units/ml solution for injection (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12035", "description": "Insulin zinc mixed bovine 100units/ml suspension for injection 10ml vials", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12060", "description": "INSULIN QUICKSOL (SOLUBLE NEUTRAL) 100 I/U INJ", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12244", "description": "INSULIN ZINC BOVINE susp 100 I/U INJ", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12297", "description": "Hypurin bovine neutral 100unit/ml Injection (C P Pharmaceuticals Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12299", "description": "Semitard mc 100unit/ml Injection (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12638", "description": "Insulin soluble human pyr 100unit/ml Injection", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12654", "description": "Insulin soluble human prb 100unit/ml Injection", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "12818", "description": "Human Mixtard 50 100units/ml suspension for injection 10ml vials (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "13277", "description": "Mixtard 50 Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "13416", "description": "Insulin biphasic 100 units/ml Injection", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "13516", "description": "Hypurin bovine isophane 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Pharmaceuticals ", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "13837", "description": "Insulin biphasic isophane human prb 10:90; 100 units/ml Injection", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14270", "description": "Humalog Mix25 Pen 100units/ml suspension for injection 3ml pre-filled pen (Eli Lilly and Company Ltd", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14290", "description": "Insulatard Penfill 100units/ml suspension for injection 3ml cartridges (Novo Nordisk Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14299", "description": "Insulin glulisine 100units/ml solution for injection 3ml cartridges", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14301", "description": "Insulin detemir 100units/ml solution for injection 3ml cartridges", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14313", "description": "Insulin lispro 100units/ml solution for injection 3ml cartridges", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14330", "description": "Insulin detemir 100units/ml solution for injection 3ml pre-filled disposable devices", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14339", "description": "Hypurin Bovine Neutral 100units/ml solution for injection 10ml vials (Wockhardt UK Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14340", "description": "Hypurin Bovine Isophane 100units/ml suspension for injection 10ml vials (Wockhardt UK Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14345", "description": "Apidra 100units/ml solution for injection 3ml cartridges (Sanofi)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": "CPRD_product_code", "Category": "drug" } }, { "code": "14357", "description": "Humulin I 100units/ml suspension for injection 3ml cartridges (Eli Lilly and Company Ltd)", "attributes": { "Entity type": "res166: Insulin (CPRD GOLD)", "Coding System (CPRD_product_code)": 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