[ { "phenotype_id": "PH859", "phenotype_version_id": 1797, "name": "Dementia Alzheimer Vascular Mixed Nonspecific", "definition": "Objective: \n\nThere is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care.\n\n\nMethod: \n\nA case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer’s, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI ¼ 1.20–1.50).\n\n\nConclusion: \n\nThere is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremmer,Jackie Cassell, Elizabeth Ford, Are symptoms of insomnia in primary care associated with subsequent onset of dementia A matched retrospective case-control study. Aging and Mental Health, 24(9):1466-1471, 2020." } ], "validation": "", "citation_requirements": "", "created": "2022-04-04T07:07:01.544826Z", "author": "Richard Hoile, Naji Tabet, Helen Smith, Stephen Bremner, Jackie Cassell, Elizabeth Ford", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-04-04T07:07:01.544852Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/2000 - 31/12/2012", "concept_information": [ { "concept_id": 2609, "concept_version_id": 6631, "concept_name": "Dementia Alzheimer Vascular Mixed Nonspecific - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH859", "phenotype_version_id": 1797, "phenotype_name": "Dementia Alzheimer Vascular Mixed Nonspecific", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "1461.00", "description": "H/O: dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E000.00", "description": "Uncomplicated senile dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001.00", "description": "Presenile dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001000", "description": "Uncomplicated presenile dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E00..11", "description": "Senile dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001100", "description": "Presenile dementia with delirium", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E00..12", "description": "Senile/presenile dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001200", "description": "Presenile dementia with paranoia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001300", "description": "Presenile dementia with depression", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E001z00", "description": "Presenile dementia NOS", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E002.00", "description": "Senile dementia with depressive or paranoid fe...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E002000", "description": "Senile dementia with paranoia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E002100", "description": "Senile dementia with depression", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E002z00", "description": "Senile dementia with depressive or paranoid fe...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E003.00", "description": "Senile dementia with delirium", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004.00", "description": "Arteriosclerotic dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004000", "description": "Uncomplicated arteriosclerotic dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004100", "description": "Arteriosclerotic dementia with delirium", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004.11", "description": "Multi infarct dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004200", "description": "Arteriosclerotic dementia with paranoia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004300", "description": "Arteriosclerotic dementia with depression", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "E004z00", "description": "Arteriosclerotic dementia NOS", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00.00", "description": "[X]Dementia in Alzheimer's disease", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00000", "description": "[X]Dementia in Alzheimer's disease with early ...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00011", "description": "[X]Presenile dementiaAlzheimer's type", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00012", "description": "[X]Primary degen dementia Alzheimer's type p...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00013", "description": "[X]Alzheimer's disease type 2", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00100", "description": "[X]Dementia in Alzheimer's disease with late o...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00111", "description": "[X]Alzheimer's disease type 1", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00112", "description": "[X]Senile dementiaAlzheimer's type", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00113", "description": "[X]Primary degen dementia of Alzheimer's type...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00200", "description": "[X]Dementia in Alzheimer's dis atypical or mi...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00z00", "description": "[X]Dementia in Alzheimer's disease unspecified", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu00z11", "description": "[X]Alzheimer's dementia unspec", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01.00", "description": "[X]Vascular dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01000", "description": "[X]Vascular dementia of acute onset", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01100", "description": "[X]Multi-infarct dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01.11", "description": "[X]Arteriosclerotic dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01111", "description": "[X]Predominantly cortical dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01200", "description": "[X]Subcortical vascular dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01300", "description": "[X]Mixed cortical and subcortical vascular dem...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01y00", "description": "[X]Other vascular dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu01z00", "description": "[X]Vascular dementia unspecified", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu02y00", "description": "[X]Dementia in other specified diseases classi...", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu02z00", "description": "[X] Unspecified dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu02z11", "description": "[X] Presenile dementia NOS", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu02z13", "description": "[X] Primary degenerative dementia NOS", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu02z14", "description": "[X] Senile dementia NOS", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu02z16", "description": "[X] Senile dementia depressed or paranoid type", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Eu04100", "description": "[X]Delirium superimposed on dementia", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F110.00", "description": "Alzheimer's disease", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F110000", "description": "Alzheimer's disease with early onset", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F110100", "description": "Alzheimer's disease with late onset", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "F112.00", "description": "Senile degeneration of brain", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Fyu3000", "description": "[X]Other Alzheimer's disease", "attributes": { "Entity type": "res78: Dementia_Alzheimer_Vascular_Mixed_Nonspecific", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/4099-4s49", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1797, "version_name": "Dementia Alzheimer Vascular Mixed Nonspecific", "version_date": "2022-04-04T07:07:01.571515Z", "is_published": true, "is_latest": true } ] } ]