[
  {
    "phenotype_id": "PH867",
    "phenotype_version_id": 1813,
    "name": "Indigestion",
    "definition": "Background: \n\nStudies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other second-line antidepressants.\n\n\nMethods: \n\nThis cohort study used English primary care electronic medical records, hospital admission records, and mortality data from the Clinical Practice Research Datalink (CPRD), for the period 01 January 2005 to 30 November 2018. It included people aged 18–99 years with depression first prescribed a selective serotonin reuptake inhibitor (SSRI) and then prescribed mirtazapine (5081), a different SSRI (15,032), amitriptyline (3905), or venlafaxine (1580). Follow-up was from starting to stopping the second antidepressant, with a 6-month wash-out window, censoring at the end of CPRD follow-up or 30 November 2018. Age-sex standardised rates of all-cause mortality and death due to circulatory system disease, cancer, or respiratory system disease were calculated. Survival analyses were performed, accounting for baseline characteristics using inverse probability of treatment weighting.\n\n\nResults: \n\nThe cohort contained 25,598 people (median age 41 years). The mirtazapine group had the highest standardised mortality rate, with an additional 7.8 (95% confidence interval (CI) 5.9–9.7) deaths/1000 person-years compared to the SSRI group. Within 2 years of follow-up, the risk of all-cause mortality was statistically significantly higher in the mirtazapine group than in the SSRI group (weighted hazard ratio (HR) 1.62, 95% CI 1.28–2.06). No significant difference was found between the mirtazapine group and the amitriptyline (HR 1.18, 95% CI 0.85–1.63) or venlafaxine (HR 1.11, 95% CI 0.60–2.05) groups. After 2 years, the risk was significantly higher in the mirtazapine group compared to the SSRI (HR 1.51, 95% CI 1.04–2.19), amitriptyline (HR 2.59, 95% CI 1.38–4.86), and venlafaxine (HR 2.35, 95% CI 1.02–5.44) groups. The risks of death due to cancer (HR 1.74, 95% CI 1.06–2.85) and respiratory system disease (HR 1.72, 95% CI 1.07–2.77) were significantly higher in the mirtazapine than in the SSRI group.\n\n\nConclusions: \n\nMortality was higher in people prescribed mirtazapine than people prescribed a second SSRI, possibly reflecting residual differences in other risk factors between the groups. Identifying these potential health risks when prescribing mirtazapine may help reduce the risk of mortality.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Rebecca M Joseph, Ruth H Jack, Richard Morriss, Roger David Knaggs, Debbie Buttler, Chris Hollis, Julia Hippisley-Cox, Carrol Coupland, The risk of all-cause and cause-specific mortality in people prescribed mirtazapine an active comparator cohort study using electronic health records. BMC Medicine, 20(43), 2022."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2022-04-04T07:07:16.771300Z",
    "author": "Rebecca M Joseph, Ruth H Jack, Richard Morriss, Roger David Knaggs, Debbie Buttler, Chris Hollis, Julia Hippisley-Cox, Carrol Coupland",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2022-04-04T07:07:16.771324Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/01/2005 - 30/11/2018",
    "concept_information": [
      {
        "concept_id": 2617,
        "concept_version_id": 6647,
        "concept_name": "Indigestion - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH867",
        "phenotype_version_id": 1813,
        "phenotype_name": "Indigestion",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "171J.00",
            "description": "reflux cough",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "195..00",
            "description": "indigestion symptoms",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1952.00",
            "description": "regurgitates food",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1952.11",
            "description": "regurgitation",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1953.00",
            "description": "waterbrash",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1953.11",
            "description": "waterbrash symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1954.00",
            "description": "indigestion",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1955.00",
            "description": "heartburn",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1955.11",
            "description": "heartburn symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1956.00",
            "description": "peptic ulcer symptoms",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1957.00",
            "description": "gastric reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1958.00",
            "description": "undiagnosed dyspepsia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "195Z.00",
            "description": "indigestion symptom nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "198..00",
            "description": "nausea",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1981.00",
            "description": "no nausea",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "198..11",
            "description": "c/o - nausea",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "198..12",
            "description": "nausea symptoms",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1982.00",
            "description": "nausea present",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1983.00",
            "description": "morning nausea",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1984.00",
            "description": "upset stomach",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1984.11",
            "description": "upset tummy",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "198Z.00",
            "description": "nausea nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "199..00",
            "description": "vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1991.00",
            "description": "no vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "199..11",
            "description": "c/o - vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "199..12",
            "description": "emesis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "199..13",
            "description": "rumination",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "199..14",
            "description": "vomiting symptoms",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1992.00",
            "description": "vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1992.11",
            "description": "throwing up",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1992.12",
            "description": "bilious attack",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1993.00",
            "description": "projectile vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1994.00",
            "description": "vomiting blood - fresh",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1994.11",
            "description": "blood in vomit - symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1995.00",
            "description": "vomiting blood - coffee ground",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1996.00",
            "description": "vomiting - bile stained",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1997.00",
            "description": "retching",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1999.00",
            "description": "frequency of vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "199Z.00",
            "description": "vomiting nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19A..00",
            "description": "abdominal distension symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19A2.00",
            "description": "abdomen feels bloated",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19A3.00",
            "description": "abdomen feels distended",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19A4.00",
            "description": "abdomen feels swollen",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19AZ.00",
            "description": "abd. distension symptom nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B..00",
            "description": "flatulence/wind",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B..11",
            "description": "belching symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B..12",
            "description": "bloating symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B..13",
            "description": "eructation symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B..14",
            "description": "flatulence symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B..15",
            "description": "wind symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B2.00",
            "description": "excessive flatulence",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B3.00",
            "description": "excessive belching",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B4.00",
            "description": "excessive eructation",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19B5.00",
            "description": "excessive flatus",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19BZ.00",
            "description": "wind nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19FZ.11",
            "description": "diarrhoea & vomiting, symptom",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "19G..00",
            "description": "diarrhoea and vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J101100",
            "description": "reflux oesophagitis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J101111",
            "description": "acid reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J101112",
            "description": "gastro-oesophageal reflux with oesophagitis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J101113",
            "description": "oesophageal reflux with oesophagitis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J10y400",
            "description": "oesopheal reflux without mention of oesophagitis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J10y411",
            "description": "oesophageal reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J10y412",
            "description": "gastro-oesophageal reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J10y413",
            "description": "acid reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J10y500",
            "description": "laryngopharyngeal reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J154111",
            "description": "biliary reflux",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J161.00",
            "description": "acute dilatation of stomach",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J162.00",
            "description": "persistent vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J162.11",
            "description": "emesis - persistent",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J162z00",
            "description": "persistent vomiting nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y200",
            "description": "hyperchlorhydria",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y211",
            "description": "hyperacidity",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y300",
            "description": "hourglass stomach contraction",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y400",
            "description": "dyspepsia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y411",
            "description": "flatulent dyspepsia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y412",
            "description": "indigestion nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y500",
            "description": "functional vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y600",
            "description": "gastric atonia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y700",
            "description": "gastric spasm",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y800",
            "description": "gastric dysmotility",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16y900",
            "description": "delayed gastric emptying",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16yA00",
            "description": "non-ulcer dyspepsia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16yA11",
            "description": "functional dyspepsia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16yz00",
            "description": "other specified stomach function disorders nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16z.00",
            "description": "stomach function disorder nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J16z100",
            "description": "drug induced gastrointestinal disturbance",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J680.00",
            "description": "haematemesis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "J680.11",
            "description": "vomiting of blood",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070.00",
            "description": "[d]nausea and vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070000",
            "description": "[d]nausea",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070100",
            "description": "[d]vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070111",
            "description": "[d] sickness",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070200",
            "description": "[d]emesis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070300",
            "description": "[d]drug induced vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070400",
            "description": "[d]projectile vomiting",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070z00",
            "description": "[d]nausea and vomiting nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R070z12",
            "description": "[d]retching",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R071.00",
            "description": "[d]heartburn",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R071000",
            "description": "[d]pyrosis",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R071100",
            "description": "[d]waterbrash",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R071z00",
            "description": "[d]heartburn nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R072.00",
            "description": "[d]dysphagia",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R072000",
            "description": "[d]difficulty in swallowing",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R072z00",
            "description": "[d]dysphagia nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073.00",
            "description": "[d]flatulence, eructation and gas pain",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073000",
            "description": "[d]flatulence",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073100",
            "description": "[d]eructation",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073200",
            "description": "[d]gas pain (abdominal)",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073300",
            "description": "[d]abdominal distension, gaseous",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073400",
            "description": "[d]bloating",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073500",
            "description": "[d]tympanites (abdominal)",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073z00",
            "description": "[d]flatulence, eructation and gas pain nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R073z11",
            "description": "[d]wind",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R075.00",
            "description": "[d]bowel sounds abnormal",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R075100",
            "description": "[d]bowel sounds hyperactive",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R075z00",
            "description": "[d]abnormal bowel sounds nos",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "R07A.00",
            "description": "[d]pain in oesophagus",
            "attributes": {
              "Entity type": "res176: Indigestion",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/ce3q-1n75",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1813,
        "version_name": "Indigestion",
        "version_date": "2022-04-04T07:07:16.797706Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]