[
  {
    "phenotype_id": "PH908",
    "phenotype_version_id": 1895,
    "name": "Alcohol-Related Mortality",
    "definition": "IMPORTANCE:\n\nPeople diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear.\n\n\nOBJECTIVE:\n\nTo investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality.\n\n\nDESIGN, SETTING, AND PARTICIPANTS:\n\nAn incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research atalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National tatistics (ONS) mortality records. Patients with psoriasis were matched with up to 20 comparison patients without psoriasis on age, sex, and general practice.\n\n\nMAIN OUTCOMES AND MEASURES: \n\nAlcohol-related deathswere ascertained via the Office for National Statistics mortality records. A stratified Cox proportional hazard model was used to estimate the cause-specific hazard ratio for alcohol-related death, with adjustment for socioeconomic status.\n\n\nRESULTS: \n\nThe cohort included 55 537 with psoriasis and 854 314 patients without psoriasis. Median (interquartile) age at index date was 47 (27) years; 408 230 of total patients (44.9%) were men. During a median (IQR) of 4.4 (6.2) years of follow-up, the alcohol-related mortality rate was 4.8 per 10 000 person-years (95%CI, 4.1-5.6; n = 152) for the psoriasis cohort, vs 2.5 per 10 000 (95%CI, 2.4- 2.7; n = 1118) for the comparison cohort. The hazard ratio for alcohol-related death in patients with psoriasis was 1.58 (95%CI, 1.31-1.91), and the predominant causes of alcohol-related deaths were alcoholic liver disease (65.1%), fibrosis and cirrhosis of the liver (23.7%), and mental and behavioral disorders due to alcohol (7.9%).\n\n\nCONCLUSIONS AND RELEVANCE:\n\nPeople with psoriasis have approximately a 60%greater risk of dying due to alcohol-related causes compared with peers of the same age and sex in the general population. This appears to be a key contributor to the premature mortality gap. These findings call for routine screening, identification and treatment, using the Alcohol Use Disorders Identification Test (AUDIT-C) in both primary and secondary care to detect alcohol consumption and misuse among people diagnosed with psoriasis.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft, Alcohol-Related Mortality in Patients With Psoriasis A Population-Based Cohort Study. JAMA Dermatology, 153(12):1256-1262, 2017."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2022-04-04T07:09:28.519051Z",
    "author": "Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2022-04-04T07:09:28.519075Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "ICD10 codes",
        "value": 4
      },
      {
        "name": "ICD9 codes",
        "value": 17
      }
    ],
    "event_date_range": "01/01/1998 - 03/03/2014",
    "concept_information": [
      {
        "concept_id": 2680,
        "concept_version_id": 6773,
        "concept_name": "Alcohol-Related Mortality - Primary Care",
        "coding_system": {
          "id": 17,
          "name": "ICD9 codes",
          "description": "ICD9 codes"
        },
        "phenotype_id": "PH908",
        "phenotype_version_id": 1895,
        "phenotype_name": "Alcohol-Related Mortality",
        "code_attribute_header": [
          "Entity type",
          "Coding System (ICD-10 ICD-9)",
          "Category"
        ],
        "codes": [
          {
            "code": "291",
            "description": "Alcoholic psychoses",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-9",
              "Category": "diagnostic"
            }
          },
          {
            "code": "303",
            "description": "Alcohol dependence syndrome",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-9",
              "Category": "diagnostic"
            }
          },
          {
            "code": "305",
            "description": "Non-dependent abuse of alcohol",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-9",
              "Category": "diagnostic"
            }
          },
          {
            "code": "425.5",
            "description": "Alcoholic cardiomyopathy",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-9",
              "Category": "diagnostic"
            }
          },
          {
            "code": "571",
            "description": "Chronic liver disease and cirrhosis (Excluding 571.6 - Biliary cirrhosis)",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-9",
              "Category": "diagnostic"
            }
          },
          {
            "code": "E860",
            "description": "Accidental poisoning by alcohol",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-9",
              "Category": "diagnostic"
            }
          }
        ]
      },
      {
        "concept_id": 2681,
        "concept_version_id": 6775,
        "concept_name": "Alcohol-Related Mortality - Primary Care",
        "coding_system": {
          "id": 4,
          "name": "ICD10 codes",
          "description": "ICD10 Codes"
        },
        "phenotype_id": "PH908",
        "phenotype_version_id": 1895,
        "phenotype_name": "Alcohol-Related Mortality",
        "code_attribute_header": [
          "Entity type",
          "Coding System (ICD-10 ICD-9)",
          "Category"
        ],
        "codes": [
          {
            "code": "F10",
            "description": "Mental and behavioural disorders due to use of alcohol",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "G31.2",
            "description": "Degeneration of nervous system due to alcohol",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "G62.1",
            "description": "Alcoholic polyneuropathy",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "I42.6",
            "description": "Alcoholic cardiomyopathy",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "K29.2",
            "description": "Alcoholic gastritis",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "K70",
            "description": "Alcoholic liver disease",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "K73",
            "description": "Chronic hepatitis, not elsewhere classified",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "K74",
            "description": "Fibrosis and cirrhosis of liver (Excluding K74.3?K74.5 - Biliary cirrhosis)",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "K86.0",
            "description": "Alcohol induced chronic pancreatitis",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "X45",
            "description": "Accidental poisoning by and exposure to alcohol",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "X65",
            "description": "Intentional self-poisoning by and exposure to alcohol",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          },
          {
            "code": "Y15",
            "description": "Poisoning by and exposure to alcohol, undetermined intent",
            "attributes": {
              "Entity type": "res61: Alcohol-related mortality",
              "Coding System (ICD-10 ICD-9)": "ICD-10",
              "Category": "diagnostic"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/9w9y-na18",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1895,
        "version_name": "Alcohol-Related Mortality",
        "version_date": "2022-04-04T07:09:28.545832Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]