[ { "phenotype_id": "PH911", "phenotype_version_id": 1901, "name": "Psoriasis", "definition": "IMPORTANCE:\n\nPeople diagnosed with psoriasis have an increased risk of premature mortality, but the underlying reasons for this mortality gap are unclear.\n\n\nOBJECTIVE:\n\nTo investigate whether patients with psoriasis have an elevated risk of alcohol-related mortality.\n\n\nDESIGN, SETTING, AND PARTICIPANTS:\n\nAn incident cohort of patients with psoriasis aged 18 years and older was delineated for 1998 through 2014 using the Clinical Practice Research atalink (CPRD) and linked to Hospital Episode Statistics (HES) and Office for National tatistics (ONS) mortality records. Patients with psoriasis were matched with up to 20 comparison patients without psoriasis on age, sex, and general practice.\n\n\nMAIN OUTCOMES AND MEASURES: \n\nAlcohol-related deathswere ascertained via the Office for National Statistics mortality records. A stratified Cox proportional hazard model was used to estimate the cause-specific hazard ratio for alcohol-related death, with adjustment for socioeconomic status.\n\n\nRESULTS: \n\nThe cohort included 55 537 with psoriasis and 854 314 patients without psoriasis. Median (interquartile) age at index date was 47 (27) years; 408 230 of total patients (44.9%) were men. During a median (IQR) of 4.4 (6.2) years of follow-up, the alcohol-related mortality rate was 4.8 per 10 000 person-years (95%CI, 4.1-5.6; n = 152) for the psoriasis cohort, vs 2.5 per 10 000 (95%CI, 2.4- 2.7; n = 1118) for the comparison cohort. The hazard ratio for alcohol-related death in patients with psoriasis was 1.58 (95%CI, 1.31-1.91), and the predominant causes of alcohol-related deaths were alcoholic liver disease (65.1%), fibrosis and cirrhosis of the liver (23.7%), and mental and behavioral disorders due to alcohol (7.9%).\n\n\nCONCLUSIONS AND RELEVANCE:\n\nPeople with psoriasis have approximately a 60%greater risk of dying due to alcohol-related causes compared with peers of the same age and sex in the general population. This appears to be a key contributor to the premature mortality gap. These findings call for routine screening, identification and treatment, using the Alcohol Use Disorders Identification Test (AUDIT-C) in both primary and secondary care to detect alcohol consumption and misuse among people diagnosed with psoriasis.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft, Alcohol-Related Mortality in Patients With Psoriasis A Population-Based Cohort Study. JAMA Dermatology, 153(12):1256-1262, 2017." } ], "validation": "", "citation_requirements": "", "created": "2022-04-04T07:09:37.618092Z", "author": "Rosa Parisi, Roger T. Webb, Mathew J. Carr, Kieran J. Moriarty, Elise Kleyn, Christopher E. M. Griffiths, Darren M. Ashcroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-04-04T07:09:37.618202Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1998 - 03/03/2014", "concept_information": [ { "concept_id": 2686, "concept_version_id": 6785, "concept_name": "Psoriasis - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH911", "phenotype_version_id": 1901, "phenotype_name": "Psoriasis", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "M16..00", "description": "Psoriasis and similar disorders", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161.00", "description": "Other psoriasis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161000", "description": "Psoriasis unspecified", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161100", "description": "Psoriasis annularis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161200", "description": "Psoriasis circinata", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161300", "description": "Psoriasis diffusa", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161400", "description": "Psoriasis discoidea", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161500", "description": "Psoriasis geographica", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161600", "description": "Guttate psoriasis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161700", "description": "Psoriasis gyrata", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161800", "description": "Psoriasis inveterata", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161900", "description": "Psoriasis ostracea", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161A00", "description": "Psoriasis palmaris", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161B00", "description": "Psoriasis plantaris", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161C00", "description": "Psoriasis punctata", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161E00", "description": "Psoriasis universalis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161F00", "description": "Psoriasis vulgaris", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161F11", "description": "Chronic large plaque psoriasis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161H00", "description": "Erythrodermic psoriasis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161z00", "description": "Psoriasis NOS", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16y.00", "description": "Other psoriasis and similar disorders", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16y000", "description": "Scalp psoriasis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16z.00", "description": "Psoriasis and similar disorders NOS", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Myu3000", "description": "[X]Other psoriasis", "attributes": { "Entity type": "res61: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/73g9-j674", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1901, "version_name": "Psoriasis", "version_date": "2022-04-04T07:09:37.642903Z", "is_published": true, "is_latest": true } ] } ]