[ { "phenotype_id": "PH912", "phenotype_version_id": 1903, "name": "Psoriasis", "definition": "The association between psoriasis and risk of major cardiovascular (CV) events (myocardial infarction, acute coronary syndrome, unstable angina, and stroke) is unclear. A cohort study with 48,523 patients with psoriasis and 208,187 controls was conducted. During a median follow-up of 5.2 years, 1,257 patients with psoriasis (2.59%) had a major CV event, compared with 4,784 controls (2.30%). In the multivariable analysis, inflammatory arthritis hazard ratio (HR) 1.36 (1.18–1.58), diabetes HR 1.18 (1.06–1.31), chronic kidney disease HR 1.18 (1.07–1.31), hypertension HR 1.37 (1.29–1.45), transient ischemic attack HR 2.74 (2.41–3.12), atrial fibrillation HR 1.54 (1.36–1.73), valvular heart disease HR 1.23 (1.05–1.44), thromboembolism 1.32 (1.17–1.49), congestive heart failure HR 1.57 (1.39–1.78), depression HR 1.16 (1.01–1.34), current smoker HR 2.18 (2.03–2.33), age (year) HR 1.07 (1.07–1.07), and male gender HR 1.83 (1.69–1.98) were statistically significant for the risk of major CV events. The age- and genderadjusted HRs of a major CV event for psoriasis were 1.10 (1.04–1.17) and for severe psoriasis 1.40 (1.07–1.84), whereas the fully adjusted HRs were attenuated to 1.02 (0.95–1.08) and 1.28 (0.96–1.69). In conclusion, neither psoriasis nor severe psoriasis were associated with the short-to-medium term (over 3–5 years) risk of major CV events after adjusting for known cardiovascular disease risk factors.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M. Ashcroft, Psoriasis and the Risk of Major Cardiovascular Events Cohort Study Using the Clinical Practice Research Datalink. Journal of Investigative Dermatology, 135, 2015." } ], "validation": "", "citation_requirements": "", "created": "2022-04-04T07:09:39.192945Z", "author": "Rosa Parisi, Martin K Rutter, Mark Lunt, Helen S Young, Deborah P M Symmons, Christopher E M Griffiths, Darren M. Ashcroft", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-04-04T07:09:39.192970Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/1994 - 31/12/2009", "concept_information": [ { "concept_id": 2687, "concept_version_id": 6787, "concept_name": "Psoriasis - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH912", "phenotype_version_id": 1903, "phenotype_name": "Psoriasis", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "M16..00", "description": "Psoriasis and similar disorders", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161.00", "description": "Other psoriasis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161000", "description": "Psoriasis unspecified", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161100", "description": "Psoriasis annularis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161200", "description": "Psoriasis circinata", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161300", "description": "Psoriasis diffusa", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161400", "description": "Psoriasis discoidea", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161500", "description": "Psoriasis geographica", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161600", "description": "Guttate psoriasis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161700", "description": "Psoriasis gyrata", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161800", "description": "Psoriasis inveterata", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161900", "description": "Psoriasis ostracea", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161A00", "description": "Psoriasis palmaris", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161B00", "description": "Psoriasis plantaris", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161C00", "description": "Psoriasis punctata", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161E00", "description": "Psoriasis universalis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161F00", "description": "Psoriasis vulgaris", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161F11", "description": "Chronic large plaque psoriasis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161H00", "description": "Erythrodermic psoriasis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M161z00", "description": "Psoriasis NOS", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16y.00", "description": "Other psoriasis and similar disorders", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16y000", "description": "Scalp psoriasis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "M16z.00", "description": "Psoriasis and similar disorders NOS", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Myu3000", "description": "[X]Other psoriasis", "attributes": { "Entity type": "res66: psoriasis", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/z1jy-gj26", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1903, "version_name": "Psoriasis", "version_date": "2022-04-04T07:09:39.218489Z", "is_published": true, "is_latest": true } ] } ]