[
  {
    "phenotype_id": "PH920",
    "phenotype_version_id": 1919,
    "name": "Chronic Kidney Disease (CKD)",
    "definition": "BACKGROUND: \n\nWith recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.\n\n\nMETHODS: \n\nIn this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.\n\n\nRESULTS: \n\nCompared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.\n\n\nCONCLUSIONS: \n\nCompared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2022-04-04T07:10:45.109630Z",
    "author": "Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2022-04-04T07:10:45.109655Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Disease or syndrome",
        "value": "2"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/01/2006 - 31/12/2013",
    "concept_information": [
      {
        "concept_id": 2695,
        "concept_version_id": 6803,
        "concept_name": "Chronic Kidney Disease (CKD) - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH920",
        "phenotype_version_id": 1919,
        "phenotype_name": "Chronic Kidney Disease (CKD)",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "1Z10.00",
            "description": "Chronic kidney disease stage 1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z11.00",
            "description": "Chronic kidney disease stage 2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z12.00",
            "description": "Chronic kidney disease stage 3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z13.00",
            "description": "Chronic kidney disease stage 4",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z14.00",
            "description": "Chronic kidney disease stage 5",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z15.00",
            "description": "Chronic kidney disease stage 3A",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z16.00",
            "description": "Chronic kidney disease stage 3B",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z17.00",
            "description": "Chronic kidney disease stage 1 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z17.11",
            "description": "CKD stage 1 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z18.00",
            "description": "Chronic kidney disease stage 1 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z18.11",
            "description": "CKD stage 1 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z19.00",
            "description": "Chronic kidney disease stage 2 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z19.11",
            "description": "CKD stage 2 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1a.00",
            "description": "CKD with GFR category G4 & albuminuria category A1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1A.00",
            "description": "Chronic kidney disease stage 2 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1A.11",
            "description": "CKD stage 2 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1b.00",
            "description": "CKD with GFR category G4 & albuminuria category A2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1B.00",
            "description": "Chronic kidney disease stage 3 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1B.11",
            "description": "CKD stage 3 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1c.00",
            "description": "CKD with GFR category G4 & albuminuria category A3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1C.00",
            "description": "Chronic kidney disease stage 3 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1C.11",
            "description": "CKD stage 3 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1d.00",
            "description": "CKD with GFR category G5 & albuminuria category A1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1D.00",
            "description": "Chronic kidney disease stage 3A with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1D.11",
            "description": "CKD stage 3A with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1e.00",
            "description": "CKD with GFR category G5 & albuminuria category A2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1E.00",
            "description": "Chronic kidney disease stage 3A without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1E.11",
            "description": "CKD stage 3A without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1f.00",
            "description": "CKD with GFR category G5 & albuminuria category A3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1F.00",
            "description": "Chronic kidney disease stage 3B with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1F.11",
            "description": "CKD stage 3B with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1G.00",
            "description": "Chronic kidney disease stage 3B without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1G.11",
            "description": "CKD stage 3B without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1H.00",
            "description": "Chronic kidney disease stage 4 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1H.11",
            "description": "CKD stage 4 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1J.00",
            "description": "Chronic kidney disease stage 4 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1J.11",
            "description": "CKD stage 4 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1K.00",
            "description": "Chronic kidney disease stage 5 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1K.11",
            "description": "CKD stage 5 with proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1L.00",
            "description": "Chronic kidney disease stage 5 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1L.11",
            "description": "CKD stage 5 without proteinuria",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1M.00",
            "description": "CKD with GFR category G1 & albuminuria category A1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1N.00",
            "description": "CKD with GFR category G1 & albuminuria category A2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1P.00",
            "description": "CKD with GFR category G1 & albuminuria category A3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1Q.00",
            "description": "CKD with GFR category G2 & albuminuria category A1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1R.00",
            "description": "CKD with GFR category G2 & albuminuria category A2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1S.00",
            "description": "CKD with GFR category G2 & albuminuria category A3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1T.00",
            "description": "CKD with GFR category G3a & albuminuria category A1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1V.00",
            "description": "CKD with GFR category G3a & albuminuria category A2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1W.00",
            "description": "CKD with GFR category G3a & albuminuria category A3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1X.00",
            "description": "CKD with GFR category G3b & albuminuria category A1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1Y.00",
            "description": "CKD with GFR category G3b & albuminuria category A2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1Z1Z.00",
            "description": "CKD with GFR category G3b & albuminuria category A3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "K051.00",
            "description": "Chronic kidney disease stage 1",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "K052.00",
            "description": "Chronic kidney disease stage 2",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "K053.00",
            "description": "Chronic kidney disease stage 3",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "K054.00",
            "description": "Chronic kidney disease stage 4",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "K055.00",
            "description": "Chronic kidney disease stage 5",
            "attributes": {
              "Entity type": "res72: CKD",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/wn7r-mw97",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1919,
        "version_name": "Chronic Kidney Disease (CKD)",
        "version_date": "2022-04-04T07:10:45.136557Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]