[
  {
    "phenotype_id": "PH924",
    "phenotype_version_id": 1927,
    "name": "Hormone Replacement Therapy",
    "definition": "BACKGROUND: \n\nWith recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.\n\n\nMETHODS: \n\nIn this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.\n\n\nRESULTS: \n\nCompared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.\n\n\nCONCLUSIONS: \n\nCompared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2022-04-04T07:10:57.621312Z",
    "author": "Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2022-04-04T07:10:57.621336Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Drug",
        "value": "3"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "GPRD product codes",
        "value": 14
      }
    ],
    "event_date_range": "01/01/2006 - 31/12/2013",
    "concept_information": [
      {
        "concept_id": 2699,
        "concept_version_id": 6811,
        "concept_name": "Hormone Replacement Therapy - Primary Care",
        "coding_system": {
          "id": 14,
          "name": "GPRD product codes",
          "description": "GPRD product codes"
        },
        "phenotype_id": "PH924",
        "phenotype_version_id": 1927,
        "phenotype_name": "Hormone Replacement Therapy",
        "code_attribute_header": [
          "Entity type",
          "Coding System (CPRD_product_code)",
          "Category"
        ],
        "codes": [
          {
            "code": "10052",
            "description": "PROGYNOVA TS 50 patch 50mcg/24hours (3.8 mg/unit) [BAYER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10076",
            "description": "ESTRADOT patch 75 micrograms/24 hours (1.17mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10096",
            "description": "ESTRADOT patch 100 micrograms/24 hours (1.56mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10126",
            "description": "ESTRADOT patch 25 micrograms/24 hours (0.39mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1014",
            "description": "ESTRAPAK 50 patch and tablets 50mcg/24hours(4mg/unit) + 1mg [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10180",
            "description": "ESTRADOT patch 50 micrograms/24 hours (0.78mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10593",
            "description": "estriol tablets 1mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10946",
            "description": "MENOREST patch 50micrograms/24 hours (4.33mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "10967",
            "description": "MENOREST patch 37.5micrograms/24 hours (3.29mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11157",
            "description": "estradiol and (estradiol with dydrogesterone) tablets 1mg + (1mg + 10mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11363",
            "description": "estradiol and (estradiol with dydrogesterone) tablets 2mg + (2mg + 20mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11375",
            "description": "estradiol once weekly patch 50micrograms/24 hours(1.5mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11430",
            "description": "estradiol once weekly patch 25micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11511",
            "description": "estradiol and (estradiol with dydrogesterone) tablets 2mg + (2mg + 10 mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11672",
            "description": "estradiol twice weekly patch 25micrograms/24 hours (0.75mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1183",
            "description": "ESTRACOMBI TTS patch [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "11882",
            "description": "estradiol twice weekly patch 50 micrograms/24 hours (0.78mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1268",
            "description": "KLIOFEM tablets 2mg + 1mg [NOVO]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "12713",
            "description": "estradiol valerate and (estradiol valerate with norethisterone) tablets 2mg + (2mg + 1 mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "12773",
            "description": "estradiol twice weekly patch 100micrograms/24hrs (3.0mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "12788",
            "description": "estradiol with norethisterone acetate (continuous combined) tablets 1mg + 0.5mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "12807",
            "description": "estradiol with norethisterone acetate (continuous combined) tablets 2mg + 0.7mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "12907",
            "description": "estradiol and (estradiol with dydrogesterone) tablets 1mg + 5mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "12953",
            "description": "estradiol with dydrogesterone tablets 1mg + 5mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "13146",
            "description": "NOVOFEM tablets 1mg + (1mg + 1mg) [NOVO]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "13582",
            "description": "MENOREST patch 75micrograms/24hours (6.57mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "13990",
            "description": "estradiol with norethisterone acetate patch and tablets 50mcg/24hours(4mg/unit) + 1mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14027",
            "description": "estradiol with (estradiol + norethisterone acetate) tablets 1mg + (1mg + 1mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14234",
            "description": "estradiol twice weekly patch 37.5micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14569",
            "description": "estradiol and (estradiol with norethisterone) and (estradiol) triphasic tablets 2mg + (2mg + 1mg) + ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14580",
            "description": "DERMESTRIL patch 25micrograms/24 hours (2mg/unit) [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14596",
            "description": "estradiol and (estradiol with norethisterone) and (estradiol) triphasic forte tablets 4mg + (4mg + 1",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14792",
            "description": "estradiol twice weekly patch 50micrograms/24 hours(1.5mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14812",
            "description": "estradiol with (estradiol + norethisterone acetate) twice weekly patch 50mcg/24 hr + (50mcg+170mcg/2",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1488",
            "description": "EVOREL -50 patch 50mcg/24 hours (3.2mg/unit) [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1489",
            "description": "EVOREL -75 patch 75micrograms/24 hours(4.8mg/unit) [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "14950",
            "description": "estradiol with norethisterone acetate twice weekly patch (50mcg + 170mcg)/24 hr ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "15100",
            "description": "estradiol twice weekly patch 37.5micrograms/24 hours (3.29mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "15194",
            "description": "DERMESTRIL patch 100micrograms/24 hours (8mg/unit) [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "15298",
            "description": "estradiol twice weekly patch 25 micrograms/24 hours (0.39mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "15328",
            "description": "estradiol twice weekly patch 25micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "15869",
            "description": "DERMESTRIL patch 50micrograms/24 hours (4mg/unit) [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "15880",
            "description": "DERMESTRIL SEPTEM patch 75micrograms/24 hours [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "16437",
            "description": "estradiol once weekly patch 100mcg/24 hour (7.6mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "16443",
            "description": "FEMTAB CONTINUOUS tablets 2mg + 1mg [MERCK PHAR]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "16997",
            "description": "estradiol with (estradiol + norethisterone acetate) tablets 2mg + (2mg + 1 mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "17475",
            "description": "ADGYN COMBI tablets 2mg + (2mg + 1mg) [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18009",
            "description": "estradiol once weekly patch 50mcg/24hours (3.8 mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18218",
            "description": "estradiol twice weekly patch 100micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18311",
            "description": "estriol tablets 250micrograms ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18383",
            "description": "estradiol twice weekly patch 80micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18437",
            "description": "estradiol twice weekly patch 75micrograms/24hours (6.57mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18502",
            "description": "estradiol twice weekly patch 75micrograms/24 hours (2.25mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18600",
            "description": "estradiol twice weekly patch 75micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1873",
            "description": "CLIMAVAL tablets 1mg [NOV/SANDOZ]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "18901",
            "description": "estradiol twice weekly patch 50micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "19135",
            "description": "ESTRADIOL implant 50mg [ORGANON]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "19145",
            "description": "estradiol twice weekly patch 50micrograms/24 hours (4.33mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "1922",
            "description": "HORMONIN tablets [SHIRE]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "19487",
            "description": "ESTRADOT patch 37.5micrograms/24hours (0.585mg/unit) [NOVARTIS]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "20135",
            "description": "estradiol twice weekly patch 75 micrograms/24 hours (1.17mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "20155",
            "description": "estradiol once weekly patch 50micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "206",
            "description": "ESTRADERM TTS patch 100micrograms/24 hours (8mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "20888",
            "description": "ADGYN ESTRO tablets 2mg [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "20895",
            "description": "DERMESTRIL SEPTEM patch 50micrograms/24 hours [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2111",
            "description": "CLIMAGEST tablets 2mg [NOV/SANDOZ]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2115",
            "description": "KLIOVANCE tablets 1mg + 0.5mg [NOVO]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2140",
            "description": "FEMSEVEN 50 patch 50micrograms/24 hours(1.5mg/unit) [MERCK SER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2141",
            "description": "EVOREL -25 patch 25mcg/24 hours (1.6mg/unit) [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "21757",
            "description": "ESTRADIOL implant 100mg [ORGANON]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2208",
            "description": "TRISEQUENS tablets [NOVO]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "22335",
            "description": "estradiol once weekly patch 100mcg/24 hours (3.0mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2262",
            "description": "CLIMAVAL tablets 2mg [NOV/SANDOZ]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2397",
            "description": "EVOREL -100 patch 100mcg/24 hours (6.4mg/unit) [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2452",
            "description": "TRISEQUENS forte tablets [NOVO]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2457",
            "description": "estradiol valerate tablets 1mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "24764",
            "description": "estradiol and (estradiol with norethisterone) tablets 2mg + (2mg + 1mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "24917",
            "description": "estradiol valerate with norethisterone (continuous combined) tablets 2mg + 0.7mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "26049",
            "description": "estradiol twice weekly patch 100 micrograms/24 hours (1.56mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2728",
            "description": "EVOREL PAK treatment pack 50mcg/24hours(3.2mg/unit) + 1mg [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2729",
            "description": "EVOREL CONTI patch (50mcg + 170mcg)/24 hr [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2766",
            "description": "CLIMESSE tablets 2mg + 0.7mg [NOV/SANDOZ]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "28230",
            "description": "CLINORETTE tablets 2mg [RESOURCE]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "29449",
            "description": "estradiol injection 1mg/ml ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "2977",
            "description": "estradiol implant 50mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "3002",
            "description": "ELLESTE-DUET tablets 1mg [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "3040",
            "description": "ESTRADERM MX patch 50micrograms/24 hours(1.5mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "31330",
            "description": "estradiol injection 5mg/ml ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "3179",
            "description": "PROGYNOVA tablets 1mg [BAYER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "32930",
            "description": "DERMESTRIL SEPTEM patch 25micrograms/24 hours [STRAKAN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "3387",
            "description": "ESTRADERM MX patch 25micrograms/24 hours (0.75mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "3530",
            "description": "FEMOSTON tablets 1mg + 10mg [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "3553",
            "description": "FEMOSTON tablets 2mg + 10mg [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "35742",
            "description": "estradiol once weekly patch 100micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "35958",
            "description": "BEDOL tablets 2mg [RESOURCE]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "37033",
            "description": "estradiol transdermal patch 75micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "37037",
            "description": "estradiol transdermal patch 100micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "37692",
            "description": "estradiol transdermal patch 25micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "37697",
            "description": "estradiol transdermal patch 50micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "38932",
            "description": "EVOREL 50 patch [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "38935",
            "description": "EVOREL 25 patch [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "38940",
            "description": "EVOREL 75 patch [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "38965",
            "description": "EVOREL 100 patch [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "390",
            "description": "CLIMAGEST tablets 1mg [NOV/SANDOZ]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "39622",
            "description": "HORMONIN tablets [AMDIPHARM]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "41390",
            "description": "estradiol with (estradiol + norethisterone acetate) twice weekly patch ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4207",
            "description": "ELLESTE-DUET tablets 2mg [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4244",
            "description": "EVOREL SEQUI patch [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "42515",
            "description": "estradiol patch 40micrograms/24 hours (1.25mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4326",
            "description": "PROGYNOVA tablets 2mg [BAYER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4328",
            "description": "ELLESTE-SOLO tablets 1mg [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4393",
            "description": "ELLESTE-DUET CONTI tablets 2mg + 1mg [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "44461",
            "description": "Estradiol 10microgram pessaries",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "44494",
            "description": "Vagifem 10microgram vaginal tablets (Novo Nordisk Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4466",
            "description": "PROGYNOVA TS patch 50mcg/24hours (3.8 mg/unit) [SCHERING]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4467",
            "description": "PROGYNOVA TS forte patch 100mcg/24 hour (7.6mg/unit) [SCHERING]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4511",
            "description": "estradiol implant 100mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4721",
            "description": "estradiol twice weekly patch 75micrograms/24 hours(4.8mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4882",
            "description": "ESTRADERM MX patch 100micrograms/24hrs (3.0mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4909",
            "description": "ELLESTE-SOLO tablets 2mg [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4956",
            "description": "estradiol tablets 1mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "49693",
            "description": "Vagifem 25microgram vaginal tablets (Mawdsley-Brooks & Company Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "49694",
            "description": "Estraderm TTS 25 patches (DE Pharmaceuticals)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "4977",
            "description": "ESTRADERM MX patch 75micrograms/24 hours (2.25mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "49985",
            "description": "Femoston-conti 0.5mg/2.5mg tablets (BGP Products Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5005",
            "description": "estradiol twice weekly patch 50mcg/24 hours (3.2mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5012",
            "description": "estradiol with norethisterone acetate (continuous combined) tablets 2mg + 1mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "50200",
            "description": "Climagest 1mg tablets (Sigma Pharmaceuticals Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5100",
            "description": "estradiol twice weekly patch 25mcg/24 hours (1.6mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "51201",
            "description": "Estradot 50micrograms/24hours patches (Necessity Supplies Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "51546",
            "description": "Climaval 2mg tablets (Lexon (UK) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "51688",
            "description": "Evorel Conti patches (Lexon (UK) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5195",
            "description": "FEMOSTON CONTI tablets 1mg + 5mg [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "51978",
            "description": "Estraderm MX 25 patches (Stephar (U.K.) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "52174",
            "description": "Estradot 50micrograms/24hours patches (Sigma Pharmaceuticals Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "52306",
            "description": "Femoston-conti 1mg/5mg tablets (Stephar (U.K.) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "52441",
            "description": "Evorel Conti patches (DE Pharmaceuticals)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "52480",
            "description": "Estraderm MX 25 patches (Lexon (UK) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "52632",
            "description": "Vagifem 25microgram vaginal tablets (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "52813",
            "description": "Nuvelle TS Phase I patches (Bayer Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5292",
            "description": "FEMATRIX 40 patch 40micrograms/24 hours (1.25mg/unit) [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5343",
            "description": "estradiol twice weekly patch 25micrograms/24 hours (2mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "54425",
            "description": "Oestrogel Pump-Pack 0.06% gel (DE Pharmaceuticals)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "55551",
            "description": "Estradiol 500micrograms / Dydrogesterone 2.5mg tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "56056",
            "description": "Generic Elleste Duet 1mg tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "56081",
            "description": "Generic Femoston 1/10mg tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "56468",
            "description": "Oestrogel Pump-Pack 0.06% gel (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "56480",
            "description": "Evorel Conti patches (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "57514",
            "description": "Estraderm TTS 50 patches (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "57548",
            "description": "Oestrogel Pump-Pack 0.06% gel (Sigma Pharmaceuticals Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5755",
            "description": "ELLESTE-SOLO MX 40 patch 40micrograms/24 hours (1.25mg/unit) [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "57562",
            "description": "Sandrena 1mg gel sachets (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "5759",
            "description": "estradiol twice weekly patch 100micrograms/24 hours (8mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "57590",
            "description": "Progynova TS 50 patches (Dowelhurst Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "58035",
            "description": "Generic Elleste Duet 2mg tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "58516",
            "description": "Generic Femoston 2/10mg tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "58575",
            "description": "Generic Climagest 1mg tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6030",
            "description": "NUVELLE CONTINUOUS tablets 2mg + 1mg [BAYER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6059",
            "description": "estradiol twice weekly patch 100mcg/24 hours (6.4mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "60637",
            "description": "Climaval 1mg tablets (Lexon (UK) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6082",
            "description": "FEMSEVEN 75 patch 75micrograms/24 hours (2.25mg/unit) [MERCK SER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6177",
            "description": "FEMSEVEN 100 patch 100mcg/24 hours (3.0mg/unit) [MERCK SER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "62530",
            "description": "Generic Tridestra tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "64580",
            "description": "Elleste Duet Conti tablets (Mawdsley-Brooks & Company Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "64735",
            "description": "Estradot 50micrograms/24hours patches (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "64995",
            "description": "Climesse tablets (Lexon (UK) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "65009",
            "description": "Generic Trisequens tablets",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6538",
            "description": "FEMTAB tablets 2mg [MERCK PHAR]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6563",
            "description": "estradiol once weekly patch 75micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "65810",
            "description": "Femoston 2/10mg tablets (Sigma Pharmaceuticals Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6601",
            "description": "estradiol twice weekly patch 25micrograms/24 hours (2mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6603",
            "description": "estradiol with estrone and estriol tablets ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6622",
            "description": "ZUMENON tablets 2mg [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "66404",
            "description": "Climagest 1mg tablets (Waymade Healthcare Plc)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "66434",
            "description": "Generic Evorel Sequi transdermal patches",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "66575",
            "description": "Evorel 50 patches (Lexon (UK) Ltd)",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "6793",
            "description": "estradiol twice weekly patch 40micrograms/24 hours ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "7001",
            "description": "estradiol valerate tablets 2mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "7251",
            "description": "FEMTAB tablets 1mg [MERCK PHAR]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "7381",
            "description": "estradiol tablets 2mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "7388",
            "description": "ZUMENON tablets 1mg [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "8162",
            "description": "estradiol with norethisterone patch and tablets 50mcg/24hours(3.2mg/unit) + 1mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "8465",
            "description": "OVESTIN tablets 1mg [ORGANON]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "8770",
            "description": "FEMOSTON tablets 2mg + 20mg [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "8837",
            "description": "estradiol implant 25mg ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9047",
            "description": "FEMATRIX 80 patch 80mcg/24 hours (2.5mg/unit) [ABBOTT]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9234",
            "description": "EVOREL SEQUI patch 50mcg/24 hours (3.2mg/unit) [JANSSEN]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9268",
            "description": "estradiol twice weekly patch 50micrograms/24 hours (4mg/unit) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9413",
            "description": "estradiol valerate and (estradiol valerate with norethisterone) tablets 1mg + (1mg + 1mg) ",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9649",
            "description": "ELLESTE-SOLO MX 80 patch 80mcg/24 hours (2.5mg/unit) [MEDA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "986",
            "description": "ESTRADERM TTS patch 50micrograms/24 hours (4mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "988",
            "description": "ESTRADERM TTS patch 25micrograms/24 hours (2mg/unit) [NOV/CIBA]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9901",
            "description": "PROGYNOVA TS 100 patch 100mcg/24 hour (7.6mg/unit) [BAYER]",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          },
          {
            "code": "9976",
            "description": "estradiol with (estradiol + norethisterone acetate) twice weekly patch 50mcg/24 hr + (50mcg+250mcg/2",
            "attributes": {
              "Entity type": "res72: Hormone replacement therapy",
              "Coding System (CPRD_product_code)": "CPRD_product_code",
              "Category": "drug"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/4n1c-nf61",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1927,
        "version_name": "Hormone Replacement Therapy",
        "version_date": "2022-04-04T07:10:57.647532Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]