[ { "phenotype_id": "PH929", "phenotype_version_id": 1937, "name": "Obesity", "definition": "BACKGROUND: \n\nWith recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.\n\n\nMETHODS: \n\nIn this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.\n\n\nRESULTS: \n\nCompared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.\n\n\nCONCLUSIONS: \n\nCompared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.\n\n\n\n\n\n\n\n\n", "implementation": "", "publications": [ { "doi": null, "details": "Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019." } ], "validation": "", "citation_requirements": "", "created": "2022-04-04T07:11:11.498181Z", "author": "Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter", "collections": [ { "name": "ClinicalCodes Repository", "value": 25 }, { "name": "Phenotype Library", "value": 18 } ], "tags": null, "organisation": null, "world_access": 1, "updated": "2022-04-04T07:11:11.498205Z", "sex": [ { "name": "Both", "value": "3" } ], "type": [ { "name": "Disease or syndrome", "value": "2" } ], "ontology": null, "phenoflowid": "", "data_sources": [ { "name": "CPRD GOLD", "value": 5, "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f", "url": "https://healthdatagateway.org/en/dataset/694", "datasource_id": 694 } ], "coding_system": [ { "name": "Read codes v2", "value": 5 } ], "event_date_range": "01/01/2006 - 31/12/2013", "concept_information": [ { "concept_id": 2705, "concept_version_id": 6823, "concept_name": "Obesity - Primary Care", "coding_system": { "id": 5, "name": "Read codes v2", "description": "Read codes v2" }, "phenotype_id": "PH929", "phenotype_version_id": 1937, "phenotype_name": "Obesity", "code_attribute_header": [ "Entity type", "Category", "Coding System (Read)" ], "codes": [ { "code": "22A5.11", "description": "O/E - obese", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "22K5.00", "description": "Body mass index 30+ - obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "22K7.00", "description": "Body mass index 40+ - severely obese", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "22KC.00", "description": "Obese class I (body mass index 30.0 - 34.9)", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "22KD.00", "description": "Obese class II (body mass index 35.0 - 39.9)", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "22KE.00", "description": "Obese class III (BMI equal to or greater than 40.0)", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "66C4.00", "description": "Has seen dietician - obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "66C5.00", "description": "Treatment of obesity changed", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "66C6.00", "description": "Treatment of obesity started", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "8CV7.00", "description": "Anti-obesity drug therapy commenced", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C38..00", "description": "Obesity and other hyperalimentation", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C380.00", "description": "Obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C380200", "description": "Extreme obesity with alveolar hypoventilation", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C380300", "description": "Morbid obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C380400", "description": "Central obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C380500", "description": "Generalised obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C38y011", "description": "Obesity hypoventilation syndrome", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "C38z000", "description": "Simple obesity NOS", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Cyu7.00", "description": "[X]Obesity and other hyperalimentation", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "Cyu7000", "description": "[X]Other obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } }, { "code": "ZC2CM00", "description": "Dietary advice for obesity", "attributes": { "Entity type": "res72: Obesity", "Category": "diagnostic", "Coding System (Read)": "Read" } } ] } ], "status": 2, "doi": "https://doi.org/10.48533/qhb0-j930", "is_deleted": null, "publish_status": 2, "owner": "ieuan.scanlon", "template": { "id": 1, "name": "Clinical-Coded Phenotype", "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.", "version_id": 1 }, "versions": [ { "version_id": 1937, "version_name": "Obesity", "version_date": "2022-04-04T07:11:11.524731Z", "is_published": true, "is_latest": true } ] } ]