[
  {
    "phenotype_id": "PH931",
    "phenotype_version_id": 1941,
    "name": "Smoking",
    "definition": "BACKGROUND: \n\nWith recent changes in the United Kingdom’s clinical practice for diabetes mellitus care, contemporary estimates of sex disparities in cardiovascular risk and risk factor management are needed.\n\n\nMETHODS: \n\nIn this retrospective cohort study, using the Clinical Practice Research Datalink linked to hospital and death records for people in England, we identified 79 985 patients with incident type 2 diabetes mellitus (T2DM) between 2006 to 2013 matched to 386 547 patients without diabetes mellitus. Sex-stratified Cox models were used to assess cardiovascular risk.\n\n\nRESULTS: \n\nCompared with women without T2DM, women with T2DM had a higher cardiovascular event risk (adjusted hazard ratio, 1.20 [95% confidence interval, 1.12–1.28]) with similar corresponding data in men (hazard ratio, 1.12 [1.06–1.19]), leading to a nonsignificant higher relative risk in women (risk ratio, 1.07 [0.98–1.17]). However, some important sex differences in the management of risk factors were observed. Compared with men with T2DM, women with T2DM were more likely to be obese, hypertensive, and have hypercholesterolemia, but were less likely to be prescribed lipid-lowering medication and angiotensin-converting enzyme inhibitors, especially if they had cardiovascular disease.\n\n\nCONCLUSIONS: \n\nCompared with men developing T2DM, women with T2DM do not have a significantly higher relative increase in cardiovascular risk, but ongoing sex disparities in prescribing should prompt heightened efforts to improve the standard and equity of diabetes mellitus care in women and men.\n\n\n\n\n\n\n\n\n",
    "implementation": "",
    "publications": [
      {
        "doi": null,
        "details": "Alison K Wright,Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin K Rutter, , Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities. Circulation, 139:2742-2753, 2019."
      }
    ],
    "validation": "",
    "citation_requirements": "",
    "created": "2022-04-04T07:11:15.623926Z",
    "author": "Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Ian Buchan, Mamas A Mamas, Naveed Sattar, Darren M Ashcroft, Martin M Rutter",
    "collections": [
      {
        "name": "ClinicalCodes Repository",
        "value": 25
      },
      {
        "name": "Phenotype Library",
        "value": 18
      }
    ],
    "tags": null,
    "organisation": null,
    "world_access": 1,
    "updated": "2022-04-04T07:11:15.623950Z",
    "sex": [
      {
        "name": "Both",
        "value": "3"
      }
    ],
    "type": [
      {
        "name": "Lifestyle risk factor",
        "value": "4"
      }
    ],
    "ontology": null,
    "phenoflowid": "",
    "data_sources": [
      {
        "name": "CPRD GOLD",
        "value": 5,
        "uid": "a29feafa-7bdd-44e9-b977-c9d26425e67f",
        "url": "https://healthdatagateway.org/en/dataset/694",
        "datasource_id": 694
      }
    ],
    "coding_system": [
      {
        "name": "Read codes v2",
        "value": 5
      }
    ],
    "event_date_range": "01/01/2006 - 31/12/2013",
    "concept_information": [
      {
        "concept_id": 2707,
        "concept_version_id": 6827,
        "concept_name": "Smoking - Primary Care",
        "coding_system": {
          "id": 5,
          "name": "Read codes v2",
          "description": "Read codes v2"
        },
        "phenotype_id": "PH931",
        "phenotype_version_id": 1941,
        "phenotype_name": "Smoking",
        "code_attribute_header": [
          "Entity type",
          "Category",
          "Coding System (Read)"
        ],
        "codes": [
          {
            "code": "137..00",
            "description": "Tobacco consumption",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1371",
            "description": "Never smoked tobacco",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137..11",
            "description": "Smoker - amount smoked",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1371.11",
            "description": "Non-smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1372",
            "description": "Trivial smoker - < 1 cig/day",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1372.11",
            "description": "Occasional smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1373",
            "description": "Light smoker - 1-9 cigs/day",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1374",
            "description": "Moderate smoker - 10-19 cigs/d",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1375",
            "description": "Heavy smoker - 20-39 cigs/day",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1376",
            "description": "Very heavy smoker - 40+cigs/d",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1377",
            "description": "Ex-trivial smoker (<1/day)",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1378",
            "description": "Ex-light smoker (1-9/day)",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "1379",
            "description": "Ex-moderate smoker (10-19/day)",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137a.00",
            "description": "Pipe tobacco consumption",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137A.00",
            "description": "Ex-heavy smoker (20-39/day)",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137b.00",
            "description": "Ready to stop smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137B.00",
            "description": "Ex-very heavy smoker (40+/day)",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137c.00",
            "description": "Thinking about stopping smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137C.00",
            "description": "Keeps trying to stop smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137d.00",
            "description": "Not interested in stopping smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137D.00",
            "description": "Admitted tobacco cons untrue ?",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137e.00",
            "description": "Smoking restarted",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137E.00",
            "description": "Tobacco consumption unknown",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137F.00",
            "description": "Ex-smoker - amount unknown",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137G.00",
            "description": "Trying to give up smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137H.00",
            "description": "Pipe smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137I.00",
            "description": "Passive smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137j.00",
            "description": "Ex-cigarette smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137J.00",
            "description": "Cigar smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137K.00",
            "description": "Stopped smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137K000",
            "description": "Recently stopped smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137l.00",
            "description": "Ex roll-up cigarette smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137L.00",
            "description": "Current non-smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137m.00",
            "description": "Failed attempt to stop smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137M.00",
            "description": "Rolls own cigarettes",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137N.00",
            "description": "Ex pipe smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137O.00",
            "description": "Ex cigar smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137P.00",
            "description": "Cigarette smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137P.11",
            "description": "Smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137Q.00",
            "description": "Smoking started",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137Q.11",
            "description": "Smoking restarted",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137R.00",
            "description": "Current smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137S.00",
            "description": "Ex smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137T.00",
            "description": "Date ceased smoking",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137U.00",
            "description": "Not a passive smoker",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137V.00",
            "description": "Smoking reduced",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137W.00",
            "description": "Chews tobacco",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137X.00",
            "description": "Cigarette consumption",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137Y.00",
            "description": "Cigar consumption",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "137Z.00",
            "description": "Tobacco consumption NOS",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "8CAL.00",
            "description": "Smoking cessation advice",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "8H7i.00",
            "description": "Referral to smoking cessation advisor",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "8HkQ.00",
            "description": "Referral to NHS stop smoking service",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "8HTK.00",
            "description": "Referral to stop-smoking clinic",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "8IAj.00",
            "description": "Smoking cessation advice declined",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9km..00",
            "description": "Ex-smoker annual review - enhanced services administration",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9km..11",
            "description": "Ex-smoker annual review",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9kn..00",
            "description": "Non-smoker annual review - enhanced services administration",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9kn..11",
            "description": "Non-smoker annual review",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9ko..00",
            "description": "Current smoker annual review - enhanced services admin",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9ko..11",
            "description": "Current smoker annual review",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          },
          {
            "code": "9NS0200",
            "description": "Referral for smoking cessation service offered",
            "attributes": {
              "Entity type": "res72: Smoking",
              "Category": "diagnostic",
              "Coding System (Read)": "Read"
            }
          }
        ]
      }
    ],
    "status": 2,
    "doi": "https://doi.org/10.48533/b70c-f631",
    "is_deleted": null,
    "publish_status": 2,
    "owner": "ieuan.scanlon",
    "template": {
      "id": 1,
      "name": "Clinical-Coded Phenotype",
      "description": "Phenotype definitions that are based on lists of clinical codes, or algorithms using clinical codes.",
      "version_id": 1
    },
    "versions": [
      {
        "version_id": 1941,
        "version_name": "Smoking",
        "version_date": "2022-04-04T07:11:15.650733Z",
        "is_published": true,
        "is_latest": true
      }
    ]
  }
]