Methicillin-resistant Staphylococcus Aureus (Mrsa)

Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa

PH640 / 1280 Clinical-Coded Phenotype

  1. Overview

    Phenotype Type
    Disease or syndrome
    Sex
    Both
    Valid Event Date Range
    01/01/1993 - 31/12/2007
    Coding System
    Read codes v2OXMIS codes
    Data Sources
    CPRD GOLD
    Collections
    ClinicalCodes RepositoryPhenotype Library
    Tags
    No data

  2. Definition

    Design:

    Population-based case-control study in children 1 to 19 years of age.

    Setting:

    Primary care, General Practice Research Database, United Kingdom, 1994-2007.

    Participants:

    Cases were children who had MRSA diagnosed as outpatients, and controls were individually matched on age and practice, with the matched case’s diagnosis date as the index date for both.

    Main Exposures:

    Antibacterial agents prescribed 180 to 30 days prior to the index date, excluding prescriptions 30 days before the index date to prevent protopathic bias.

    Outcome Measures:

    Rate ratios (RRs) estimated from the odds ratios of exposure in cases compared with controls using conditional logistic regression, adjusted for comorbid conditions, other prescription drug use, and hospitalization.

    Results:

    The rate of MRSA was 4.5 per 100 000 per year. Of 297 cases and 9357 controls, 52.5% and 13.6%, respectively, received antibacterial drug prescriptions during the 150-day exposure window. The adjusted RR with any antibacterial drug was 3.5 (95% confidence interval [CI], 2.6-4.8). The RRs increased with the number of prescriptions (2.2 [95% CI, 1.5-3.2], 3.3 [95% CI, 1.9-5.6], 11.0 [95% CI, 5.6-21.6], and 18.2 [95% CI, 9.4-35.4] for 1, 2, 3, and >=4 prescriptions, respectively). The RR was particularly elevated for quinolones at 14.8 (95% CI, 3.9- 55.8), with wide variation among antibacterial classes.

  3. Implementation

    Implementation

    No data

  4. Clinical Code List

  5. Publication

    • Verena Schneider-Lindner, Caroline Quach, James A Hanley, Samy Suissa, Antibacterial Drugs and the Risk of Community-Associated Methicillin-Resistant Staphylococcus aureus in Children. Arch Pediatr Adolesc Med, 165(12), 2011.

    Citation Requirements

    No data

  6. API

    To Export Phenotype Details:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH640/version/1280/detail/?format=json
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get details of phenotype

    phenotype_details = client$phenotypes$get_detail(
     'PH640',
     version_id=1280
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get codelist of phenotype

    phenotype_codelist = client.phenotypes.get_detail(
     'PH640',
     version_id=1280
    )

    To Export Phenotype Code List:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH640/version/1280/export/codes/?format=json
    CSV site_root/phenotypes/PH640/version/1280/export/codes/
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get codelist of phenotype

    phenotype_codelist = client$phenotypes$get_codelist(
     'PH640',
     version_id=1280
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get codelist of phenotype

    phenotype_codelist = client.phenotypes.get_codelist(
     'PH640',
     version_id=1280
    )

  7. Version History

    Version IDNameOwnerPublish date
    1280 Methicillin-resistant Staphylococcus Aureus (Mrsa) ieuan.scanlon2021-10-06currently shown