Valvular disease - Elixhauser primary care

David Metcalfe, James Masters, Antonella Delmestri, Andrew Judge, Daniel Perry, Cheryl Zogg, Belinda Gabbe, Matthew Costa

Version ID
Disease or Syndrome
Data Sources
♀  Female ♂  Male
Agreement Date
Coding system
Read codes v2
Phenotype Library
Comorbidity Index


Valvular disease comorbidity category for Elixhauser index, defined in Read codes for primary care by David Metcalfe et. al.


  • Metcalfe, D., Masters, J., Delmestri, A. et al. Coding algorithms for defining Charlson and Elixhauser co-morbidities in Read-coded databases. BMC Med Res Methodol 19, 115 (2019).

  • Elixhauser A, Steiner C, Harris DR, et al. Comorbidity measures for use with administrative data. Med Care. 1998;36(1):8–27.

  • Lyons J, Akbari A, Agrawal U, et al Protocol for the development of the Wales Multimorbidity e-Cohort (WMC): data sources and methods to construct a population-based research platform to investigate multimorbidity BMJ Open 2021;11:e047101. doi: 10.1136/bmjopen-2020-047101

Clinical Code List

Rows: 296
Code Description Medcode
14S4.00 H/O: heart valve recipient 6631
14T3.00 H/O: artificial heart valve 17334
24D..11 O/E - aortic murmur 3138
24D..15 O/E - pulmonary murmur 12557
24D5.00 O/E - aortic systolic murmur 23007
24D6.00 O/E - aortic diastolic murmur 52770
24D7.00 O/E -pulmonary systolic murmur 4857
24D8.00 O/E-pulmonary diastolic murmur 95082
24D9.00 O/E - tricuspid murmur 59965
24G..00 Aortic valve gradient 19232
32A3.00 ECG: P mitrale 42148
7902000 Correct Fallot tetralogy- valved right ventr outflow conduit 16538
7902500 Repair of tetralogy of Fallot with absent pulmonary valve 88479
790D300 Creation of valved conduit between left ventricle and aorta 103943
790D700 Replacement of valved cardiac conduit 64509
790Dy00 Other specified creation of valved cardiac conduit 102843
791..00 Valves of heart and adjacent structures operations 30173
7910.00 Plastic repair of mitral valve 7894
7910.11 Mitral valvuloplasty 36638
7910.12 Replacement of mitral valve 3911
7910000 Allograft replacement of mitral valve 93158
7910100 Xenograft replacement of mitral valve 51658
7910200 Prosthetic replacement of mitral valve 19390
7910211 Bjork-Shiley prosthetic replacement of mitral valve 30567
7910212 Bjork-Shiley prosthetic replacement of mitral valve 57318
7910213 Carpentier prosthetic replacement of mitral valve 49592
7910214 Edwards prosthetic replacement of mitral valve 73904
7910300 Replacement of mitral valve NEC 3731
7910400 Mitral valvuloplasty NEC 22582
7910411 Mitral valve repair NEC 85856
7910y00 Other specified plastic repair of mitral valve 60957
7910z00 Plastic repair of mitral valve NOS 41168
7911.00 Plastic repair of aortic valve 9498
7911.12 Replacement of aortic valve 1756
7911000 Allograft replacement of aortic valve 43778
7911100 Xenograft replacement of aortic valve 39763
7911200 Prosthetic replacement of aortic valve 35812
7911300 Replacement of aortic valve NEC 15133
7911411 Aortic valve repair NEC 92070
7911500 Transapical aortic valve implantation 100482
7911600 Transluminal aortic valve implantation 98173
7911y00 Other specified plastic repair of aortic valve 40086
7911z00 Plastic repair of aortic valve NOS 53804
7912.00 Plastic repair of tricuspid valve 26168
7912.11 Replacement of tricuspid valve 47014
7912.12 Tricuspid valvuloplasty 93924
7912000 Allograft replacement of tricuspid valve 98580
7912100 Xenograft replacement of tricuspid valve 98783
7912200 Prosthetic replacement of tricuspid valve 66201
7912300 Replacement of tricuspid valve NEC 32930
7912500 Tricuspid valvuloplasty NEC 99557
7912511 Tricuspid valve repair NEC 96199
7912y00 Other specified plastic repair of tricuspid valve 72523
7912z00 Plastic repair of tricuspid valve NOS 72417
7913.00 Plastic repair of pulmonary valve 46836
7913.12 Replacement of pulmonary valve 38894
7913000 Allograft replacement of pulmonary valve 43923
7913100 Xenograft replacement of pulmonary valve 89936
7913200 Prosthetic replacement of pulmonary valve 63601
7913300 Replacement of pulmonary valve NEC 60533
7913411 Pulmonary valve repair NEC 95799
7913y00 Other specified plastic repair of pulmonary valve 73967
7913z00 Plastic repair of pulmonary valve NOS 94345
7914.00 Plastic repair of unspecified valve of heart 61108
7914.11 Replacement of unspecified valve of heart 29887
7914000 Allograft replacement of valve of heart NEC 72761
7914100 Xenograft replacement of valve of heart NEC 69189
7914200 Prosthetic replacement of valve of heart NEC 7276
7914211 Edwards prosthetic replacement of valve of heart 46135
7914212 Starr prosthetic replacement of valve of heart 36734
7914300 Replacement of valve of heart NEC 5643
7914411 Repair of valve of heart NEC 105655
7914500 Truncal valve repair 96247
7914600 Replacement of truncal valve 106383
7914y00 Other specified plastic repair of unspecified valve of heart 95817
7914z00 Plastic repair of unspecified valve of heart NOS 15910
7915.00 Revision of plastic repair of valve of heart 41169
7915000 Revision of plastic repair of mitral valve 17257
7915100 Revision of plastic repair of aortic valve 45256
7915200 Revision of plastic repair of tricuspid valve 61427
7915300 Revision of plastic repair of pulmonary valve 39972
7915y00 Other specified revision of plastic repair of valve of heart 63499
7915z00 Revision of plastic repair of valve of heart NOS 105159
7916.00 Open incision of heart valve 49413
7916000 Open mitral valvotomy 17812
7916200 Open tricuspid valvotomy 67931
7916y00 Other specified open specified incision of valve of heart 63493
7916z00 Open incision of valve of heart NOS 62361
7917.00 Closed incision of heart valve 67659
7917000 Closed mitral valvotomy 19246
7917200 Closed tricuspid valvotomy 99614
7917y00 Other specified closed incision of valve of heart 102236
7917z00 Closed incision of valve of heart NOS 20221
7918.00 Other open operations on valve of heart 4900
7918000 Annuloplasty of mitral valve 9396
7918100 Annuloplasty of tricuspid valve 26153
7918111 De Vega tricuspid annuloplasty 53413
7918200 Annuloplasty of valve of heart NEC 30705
7918300 Excision of vegetations of valve of heart 62095
7918400 Closure of tricuspid valve 96316
7918500 Closure of pulmonary valve 95784
7918y00 Other specified other open operation on valve of heart 44690
7918z00 Other open operation on valve of heart NOS 49379
7919.00 Therapeutic transluminal operations on valve of heart 39977
7919000 Percutaneous transluminal mitral valvotomy 53696
7919200 Percutaneous transluminal tricuspid valvotomy 107653
7919500 Percutaneous transluminal pulmonary valve perfor dilation 91802
7919600 Percutaneous transluminal pulmonary valve replacement 85957
7919y00 Therapeutic transluminal operation on heart valve OS 97908
7919z00 Therapeutic transluminal operation on heart valve NOS 97087
791A.00 Remove obstruction from structure adjacent to valve of heart 45283
791A200 Repair of subaortic stenosis 20940
791A300 Repair of supraaortic stenosis 62293
791Ay00 Removal of obstruction from struct adjacent heart valve OS 103048
791B.00 Other operations on structure adjacent to valve of heart 67570
791B200 Operations on mitral subvalvar apparatus 93485
791C500 Aortoventriculoplasty with pulmonary valve autograft 95532
791D.00 Excision of valve of heart 93968
791D000 Tricuspid valvectomy 92226
791D100 Pulmonary valvectomy 89459
791Dy00 Other specified excision of valve of heart 109622
791y.00 Heart valve or adjacent structures operations OS 48333
791z.00 Heart valve and adjacent structures operations NOS 3169
7931000 Inspection of valve of heart 43492
7A65100 Interposition of valve of vein 67550
7A65y00 Other specified repair of valve of vein 38403
7N40.00 [SO]Valve of heart 8000
7N40000 [SO]Mitral valve 5971
7N40100 [SO]Aortic valve 8796
7N40200 [SO]Tricuspid valve 12244
7N40300 [SO]Pulmonary valve 11865
7N40400 [SO]Truncal valve 109472
7N40z00 [SO]Valve of heart NEC 53920
A93..00 Cardiovascular syphilis 94940
A932.00 Syphilitic endocarditis 61562
A932.11 Syphilitic valve disease 68807
A932100 Syphilitic endocarditis of mitral valve 55918
A932200 Syphilitic endocarditis of aortic valve 92297
A932300 Syphilitic endocarditis of tricuspid valve 61436
G11..00 Mitral valve diseases 1267
G11..11 Rheumatic mitral valve disease 16545
G110.00 Mitral stenosis 1885
G110.11 Rheumatic mitral stenosis 32435
G111.00 Rheumatic mitral insufficiency 51879
G111.11 Mitral incompetence - rheumatic 21807
G111.12 Mitral regurgitation - rheumatic 22837
G112.00 Mitral stenosis with insufficiency 44488
G112.12 Mitral stenosis with incompetence 50983
G112.13 Mitral stenosis with regurgitation 44328
G113.00 Nonrheumatic mitral valve stenosis 28662
G114.00 Ruptured mitral valve cusp 57633
G11z.00 Mitral valve disease NOS 30443
G12..00 Rheumatic aortic valve disease 18100
G120.00 Rheumatic aortic stenosis 9391
G121.12 Aortic regurgitation - rheumatic 7963
G122.00 Rheumatic aortic stenosis with insufficiency 63960
G12z.00 Rheumatic aortic valve disease NOS 50809
G13..00 Diseases of mitral and aortic valves 10078
G130.00 Mitral and aortic stenosis 8274
G131.00 Mitral stenosis and aortic insufficiency 49355
G131.13 Mitral stenosis and aortic incompetence 61250
G131.14 Mitral stenosis and aortic regurgitation 17596
G132.00 Mitral insufficiency and aortic stenosis 33262
G132.12 Mitral incompetence and aortic stenosis 31759
G132.13 Mitral regurgitation and aortic stenosis 33907
G133.00 Mitral and aortic incompetence 31727
G133.11 Mitral and aortic insufficiency 94872
G133.12 Mitral and aortic regurgitation 11878
G13y.00 Multiple mitral and aortic valve involvement 70698
G13z.00 Mitral and aortic valve disease NOS 29158
G140.00 Tricuspid valve disease NEC 16373
G140000 Rheumatic tricuspid stenosis 31505
G140100 Rheumatic tricuspid insufficiency 60266
G140111 Tricuspid regurgitation - rheumatic 21980
G140112 Tricuspid incompetence - rheumatic 42239
G140200 Rheumatic tricuspid stenosis and insufficiency 93114
G14021X Rheumatic tricuspid stenosis and regurgitation 93113
G14021Y Rheumatic tricuspid stenosis and incompetence 62186
G140300 Tricuspid stenosis, cause unspecified 56029
G140400 Tricuspid insufficiency, cause unspecified 42128
G140412 Tricuspid incompetence, cause unspecified 34869
G140413 Tricuspid regurgitation, cause unspecified 9286
G140500 Tricuspid stenosis and insufficiency, cause unspecified 72306
G140514 Tricuspid stenosis and regurgitation, cause unspecified 49551
G140z00 Rheumatic tricuspid valve disease NOS 72613
G141.00 Rheumatic pulmonary valve disease 44167
G141000 Rheumatic pulmonary stenosis 62207
G141200 Rheumatic pulmonary stenosis and insufficiency 105626
G141z00 Rheumatic pulmonary valve disease NOS 36768
G14z.11 Rheumatic valvulitis, chronic NOS 59275
G54..11 Heart valve disorders - non rheumatic 28850
G540.00 Mitral valve incompetence 2977
G540.12 Mitral valve insufficiency 40949
G540.14 Mitral valve regurgitation 9450
G540.15 Mitral valve prolapse 1294
G540.16 Mitral regurgitation 561
G540000 Mitral incompetence, non-rheumatic 5058
G540100 Mitral incompetence, cause unspecified 34240
G540200 Mitral valve prolapse 31839
G540300 Mitral valve leaf prolapse 39916
G540z00 Mitral valve disorders NOS 24557
G541.00 Aortic valve disorders 4548
G541012 Aortic regurgitation, non-rheumatic 10187
G541100 Aortic stenosis, non-rheumatic 999
G541212 Aortic regurgitation alone, cause unspecified 1005
G541300 Aortic stenosis alone, cause unspecified 2343
G541400 Aortic valve stenosis with insufficiency 10964
G541500 Aortic stenosis 9591
G541600 Aortic valve sclerosis 30610
G541700 Aortic valve calcification 49185
G541z00 Aortic valve disorders NOS 19019
G542.00 Tricuspid valve disorders, non-rheumatic 2817
G542000 Tricuspid incompetence, non-rheumatic 1779
G542011 Tricuspid insufficiency, non-rheumatic 97738
G542012 Tricuspid regurgitation, non-rheumatic 35372
G542100 Tricuspid stenosis, non-rheumatic 35724
G542200 Nonrheumatic tricuspid valve stenosis with insufficiency 52271
G542X00 Nonrheumatic tricuspid valve disorder, unspecified 98538
G542z00 Tricuspid valve disorders NOS 43855
G543.00 Pulmonary valve disorders 12312
G543012 Pulmonary regurgitation, non-rheumatic 15496
G543100 Pulmonary stenosis, non-rheumatic 14723
G543215 Pulmonary regurgitation, cause unspecified 6077
G543300 Pulmonary stenosis, cause unspecified 2669
G543311 Pulmonary stenosis, cause unspecified 61878
G543400 Pulmonary valve stenosis with insufficiency 34932
G543z00 Pulmonary valve disorders NOS 19957
G544.00 Multiple valve diseases 40239
G544000 Disorders of both aortic and tricuspid valves 40582
G544100 Disorders of both mitral and tricuspid valves 19699
G544200 Combined disorders of mitral, aortic and tricuspid valves 18475
G544X00 Multiple valve disease, unspecified 57338
G54z.00 Endocarditis, valve unspecified 31979
G54z000 Incompetence of unspecified heart valve 39671
G54z013 Regurgitation of unspecified heart valve 22003
G54z014 Insufficiency of unspecified heart valve 89579
G54z100 Stenosis of unspecified heart valve 10111
G54z300 Endocarditis, valve unspecified, OS 51472
G54z500 Valvular heart disease 5743
G54zz00 Endocarditis, valve unspecified, NOS 939
Gy0..00 Cardiovascular syphilis 66090
Gyu1000 [X]Other mitral valve diseases 53756
Gyu1100 [X]Other rheumatic aortic valve diseases 94521
Gyu1200 [X]Other tricuspid valve diseases 99077
Gyu5500 [X]Other nonrheumatic mitral valve disorders 98560
Gyu5600 [X]Other aortic valve disorders 49272
Gyu5800 [X]Other pulmonary valve disorders 53959
Gyu5A00 [X]Aortic valve disorders in diseases classified elsewhere 71004
Gyu5D00 [X]Multiple valve disorders/diseases CE 100910
P60..00 Pulmonary valve anomalies 39992
P600.00 Pulmonary valve anomaly, unspecified 69940
P601.00 Congenital atresia of the pulmonary valve 3862
P601000 Hypoplasia of pulmonary valve 54488
P601z00 Congenital atresia of pulmonary valve NOS 93561
P602.00 Congenital pulmonary stenosis 22778
P602100 Congenital fusion of pulmonary valve segment 45452
P602z00 Congenital pulmonary stenosis NOS 33919
P60z.00 Other pulmonary valve anomalies 44478
P60z000 Congenital insufficiency of the pulmonary valve 107150
P60zz00 Other pulmonary valve anomaly NOS 70880
P61..00 Congenital tricuspid atresia and stenosis 12752
P610.00 Congenital tricuspid atresia 21272
P611.00 Congenital tricuspid stenosis 69169
P61z.00 Congenital tricuspid atresia or stenosis NOS 100065
P63..00 Congenital aortic valve stenosis 6886
P64..00 Congenital aortic valve insufficiency 8636
P640.00 Congenital aortic valve insufficiency, unspecified 58734
P641.00 Bicuspid aortic valve 3300
P64z.00 Congenital aortic valve insufficiency NOS 6843
P65..00 Congenital mitral stenosis 57091
P650.00 Congenital mitral stenosis, unspecified 90551
P651.00 Fused commissure of the mitral valve 73592
P652.00 Parachute deformity of the mitral valve 63069
P65z.00 Congenital mitral stenosis NOS 100291
P66..00 Congenital mitral insufficiency 61651
P6W..00 Congenital malformation of aortic and mitral valves unsp 46825
P6X..00 Congenital malformation of tricuspid valve, unspecified 50529
P6y0.00 Subaortic stenosis 16539
P6yy.11 Hypoplastic aortic orifice or valve 44767
P6yy700 Atresia of heart valve NEC 37451
P6yyC00 Fusion of mitral valve cusps 98317
P6z0.00 Unspecified anomaly of heart valve 26626
P711.13 Preductal aortic stenosis 106756
P712.13 Postductal aortic stenosis 49279
P722400 Supra-valvular aortic stenosis 53964
Pyu2200 [X]Other congenital malformations of pulmonary valve 109008
Pyu2G00 [X]Congenital malformation of tricuspid valve, unspecified 107496
Pyu2H00 [X]Congenital malformation of aortic and mitral valves unsp 107710
SP00200 Mechanical complication of heart valve prosthesis 62633
SP00400 Infect and inflammatory reaction due to cardiac valve pros 63710
SyuK611 [X] Embolism from prosthetic heart valve 63562
TB01200 Implant of heart valve prosthesis + complication, no blame 49338
ZV42200 [V]Heart valve transplanted 18780
ZV43300 [V]Has artificial heart valve 28871
ZV45H00 [V]Presence of prosthetic heart valve 40264
ZVu6e00 [X]Presence of other heart valve replacement 73754


To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH1098/version/2399/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH1098/version/2399/detail/?format=json
R Package

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# Connect to API

client = connect_to_API(public=TRUE)

# Get details of phenotype

details = get_phenotype_detail_by_version('PH1098', '2399', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH1098/version/2399/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH1098/version/2399/export/codes/?format=json
CSV site_root/phenotypes/PH1098/version/2399/export/codes/
R Package

# Download here


# Connect to API

client = connect_to_API(public=TRUE)

# Get codelists of phenotype

codelists = get_phenotype_code_list('PH1098', '2399', api_client=client)

Version History

Name Owner Publish date
2399 Valvular disease - Elixhauser primary care coldeaa 2023-02-14 currently shown

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