Phenotype Library | phenotype: Sickle-cell anaemia

Sickle-cell anaemia

Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos C, Lumbers T, Mathur R, Sofat R, Casas JP, Wong I, Hemingway H, Hingorani A

PH304

Version ID

608

Type

Disease or Syndrome

Data Sources

CPRD GOLD , HES Admitted Patient Care data for CPRD GOLD

Valid event data range

01/01/1999 - 01/07/2016

Sex

♀ Female ♂ Male

Agreement Date

2019-05-20

Coding system

Read codes v2 ICD10 codes Med codes

Collections

CALIBER Phenotype Library

Definition

At the specified date, a patient is defined as having had Sickle-cell anaemia IF they meet the criteria for any of the following on or before the specified date. The earliest date on which the individual meets any of the following criteria on or before the specified date is defined as the first event date:

Primary care

Sickle-cell anaemia diagnosis or history of diagnosis during a consultation

OR Secondary care (ICD10)

ALL diagnoses of Sickle-cell anaemia or history of diagnosis during a hospitalization

Implementation

PhenoFlow Implementation:

https://kclhi.org/phenoflow/phenotype/download/886

Publications

Kuan V., Denaxas S., Gonzalez-Izquierdo A. et al. A chronological map of 308 physical and mental health conditions from 4 million individuals in the National Health Service. The Lancet Digital Health - DOI 10.1016/S2589-7500(19)30012-3

Clinical Code List

CSV

JSON

XML

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C1556/4251 Sickle-cell anaemia - Primary care - Read codes v2

Rows: 13

Code	Description	Disease	Medcode	Category
1458.00	History of sickle cell anaemia	Sickle-cell anaemia	100001.0	History of Sickle-cell anaemia
D104211	Sickle-cell thalassaemia	Sickle-cell anaemia	31075.0	Diagnosis of Sickle-cell anaemia
D106.00	Sickle-cell anaemia	Sickle-cell anaemia	23519.0	Diagnosis of Sickle-cell anaemia
D106000	Sickle-cell anaemia of unspecified type	Sickle-cell anaemia	69964.0	Diagnosis of Sickle-cell anaemia
D106100	Sickle-cell anaemia with no crisis	Sickle-cell anaemia	32937.0	Diagnosis of Sickle-cell anaemia
D106200	Sickle-cell anaemia with crisis	Sickle-cell anaemia	31370.0	Diagnosis of Sickle-cell anaemia
D106300	Sickle-cell anaemia with haemoglobin C disease	Sickle-cell anaemia	31306.0	Diagnosis of Sickle-cell anaemia
D106400	Sickle-cell anaemia with haemoglobin D disease	Sickle-cell anaemia	8119.0	Diagnosis of Sickle-cell anaemia
D106500	Sickle-cell anaemia with haemoglobin E disease	Sickle-cell anaemia	93872.0	Diagnosis of Sickle-cell anaemia
D106z00	Sickle-cell anaemia NOS	Sickle-cell anaemia	57397.0	Diagnosis of Sickle-cell anaemia
Dyu1200	[X]Other sickle-cell disorders	Sickle-cell anaemia	48295.0	Diagnosis of Sickle-cell anaemia
F422100	Proliferative retinopathy due to sickle cell disease	Sickle-cell anaemia	11874.0	History of Sickle-cell anaemia
K0G..00	Sickle cell nephropathy	Sickle-cell anaemia	107027.0	History of Sickle-cell anaemia

C1557/4253 Sickle-cell anaemia - Primary care - Med codes

Rows: 13

Code	Description	Disease	ReadcodeDescr	Readcode
100001.0	History of Sickle-cell anaemia	Sickle-cell anaemia	History of sickle cell anaemia	1458.00
107027.0	History of Sickle-cell anaemia	Sickle-cell anaemia	Sickle cell nephropathy	K0G..00
11874.0	History of Sickle-cell anaemia	Sickle-cell anaemia	Proliferative retinopathy due to sickle cell disease	F422100
23519.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia	D106.00
31075.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell thalassaemia	D104211
31306.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia with haemoglobin C disease	D106300
31370.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia with crisis	D106200
32937.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia with no crisis	D106100
48295.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	[X]Other sickle-cell disorders	Dyu1200
57397.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia NOS	D106z00
69964.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia of unspecified type	D106000
8119.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia with haemoglobin D disease	D106400
93872.0	Diagnosis of Sickle-cell anaemia	Sickle-cell anaemia	Sickle-cell anaemia with haemoglobin E disease	D106500

C1558/4255 Sickle-cell anaemia - Secondary care - Diagnoses - ICD10 codes

Rows: 4

Code	Description	Disease	Category
D57.0	Sickle-cell anaemia with crisis	Sickle-cell anaemia	Diagnosis of Sickle-cell anaemia
D57.1	Sickle-cell anaemia without crisis	Sickle-cell anaemia	Diagnosis of Sickle-cell anaemia
D57.2	Double heterozygous sickling disorders	Sickle-cell anaemia	Diagnosis of Sickle-cell anaemia
D57.8	Other sickle-cell disorders	Sickle-cell anaemia	Diagnosis of Sickle-cell anaemia

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH304/version/608/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH304/version/608/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH304', '608', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH304/version/608/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH304/version/608/export/codes/?format=json
CSV	site_root/phenotypes/PH304/version/608/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH304', '608', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
608	Sickle-cell anaemia	ieuan.scanlon	2021-10-06	currently shown