Drugs which increase the risk of vitamin D deficiency

PH3413 / 8440

OpenSAFELY

Jan 26, 2026

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OpenCodelists Phenotype

  1. Overview

    Codelist ID
    opensafely/drugs-which-increase-the-risk-of-vitamin-d-deficiency
    Version ID
    1fcc11ed
    Coding System
    dm+d codes
    Collections
    OpenCodelistPhenotype Library
    Tags
    No data

  2. Definition

    This codelist was taken from OpenCodelists, created by OpenSAFELY. We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.

    This codelist aims to identify drugs that substantially increase the risk of vitamin D deficiency when administered on a long-term basis.

    © University of Oxford for the Bennett Institute for Applied Data Science 2025. This work may be copied freely for non-commercial research and study.

  3. Methodology

    For many drugs the likelihood of impacting vitamin D levels is difficult to quantify or based on limited evidence. This search strategy aims to include drugs where there is a weight of credible evidence that they commonly reduce vitamin D levels. A conclusion for each medication was arrived at after consulting multiple sources such including, BNF, Summary of Product Characteristics, relevant published literature. Drug classes were not included where they are known to be almost exclusively prescribed in secondary care, such as highly active antiretroviral agents or chemotherapeutic agents.

    Search terms are defined as follows: Anticonvulsants: Carbamazepine, Phenytoin/Fosphenytoin, Phenobarbital, Primidone, Valproate. Other: Colestyramine, Orlistat, Rifampicin.

    Inclusion criteria for codes: Codes which when applied in clinical records, are expected to indicate the prescription of a vitamin D–depleting medication in >99% of cases.

    Exclusion criteria for codes: Codes which when applied in clinical records, are expected to indicate the prescription of a vitamin D–depleting medication in \<99% of cases.

  4. References

    Source Reference

    https://www.opencodelists.org/codelist/opensafely/drugs-which-increase-the-risk-of-vitamin-d-deficiency/1fcc11ed

    References

  5. Clinical Codelist

  6. API

    To Export Phenotype Details:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH3413/version/8440/detail/?format=json
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get details of Phenotype

    phenotype_details = client$phenotypes$get_detail(
     'PH3413',
     version_id=8440
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get details of Phenotype

    phenotype_detail = client.phenotypes.get_detail(
     'PH3413',
     version_id=8440
    )

    To Export Phenotype Code List:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH3413/version/8440/export/codes/?format=json
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get codelist of Phenotype

    phenotype_codelist = client$phenotypes$get_codelist(
     'PH3413',
     version_id=8440
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get codelist of Phenotype

    phenotype_codelist = client.phenotypes.get_codelist(
     'PH3413',
     version_id=8440
    )

  7. Version History

    Version IDNameOwnerPublish date
    Drugs which increase the risk of vitamin D deficiency ieuan.scanlon2026-01-26 23:15