First Generation Antipsychotics excluding long acting depots DM&D

PH3422 / 8458

OpenSAFELY

Jan 26, 2026

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OpenCodelists Phenotype

  1. Overview

    Codelist ID
    opensafely/first-generation-antipsychotics-excluding-long-acting-depots-dmd
    Version ID
    1e9b227c
    Coding System
    dm+d codes
    Collections
    OpenCodelistPhenotype Library
    Tags
    No data

  2. Definition

    This codelist was taken from OpenCodelists, created by OpenSAFELY. We recommend viewing this Phenotype on the OpenCodelist website to view the most recent version.

    This code list contains the DM\&D list of medicines that are known as First Generation Antipsychotics. All formulations of these medicines have been included, except for long acting depot antipsychotics and all formulations of prochlorperazine which are included in separate code lists. All of these antipsychotics are dopamine antagonists and licensed in some form for the treatment of psychosis, although some (e.g. flupentixol) may be licensed and used for other indications such as depression. Droperidol, which is only used for post operative nausea, is not included. Also the injectable formulations of levomepromazine are not included because these are only licensed for use in palliative care.

    See First generation antipsychotics codelist

    © University of Oxford for the Bennett Institute for Applied Data Science 2025. This work may be copied freely for non-commercial research and study.

  3. Methodology

    The list was developed using antipsychotics listed in the BNF, Chapter 4.2 (Drugs used for Psychoses and Related disorders) and cross referenced against the Snomed list of antipsychotics.

  4. References

    Source Reference

    https://www.opencodelists.org/codelist/opensafely/first-generation-antipsychotics-excluding-long-acting-depots-dmd/1e9b227c

    References

  5. Clinical Codelist

  6. API

    To Export Phenotype Details:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH3422/version/8458/detail/?format=json
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get details of Phenotype

    phenotype_details = client$phenotypes$get_detail(
     'PH3422',
     version_id=8458
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get details of Phenotype

    phenotype_detail = client.phenotypes.get_detail(
     'PH3422',
     version_id=8458
    )

    To Export Phenotype Code List:

    FormatAPI
    JSON site_root/api/v1/phenotypes/PH3422/version/8458/export/codes/?format=json
    R Package

    # Download here

    library(ConceptLibraryClient)


    # Connect to API

    client = ConceptLibraryClient::Connection$new(public=TRUE)


    # Get codelist of Phenotype

    phenotype_codelist = client$phenotypes$get_codelist(
     'PH3422',
     version_id=8458
    )

    Py Package

    # Download here

    from pyconceptlibraryclient import Client


    # Connect to API

    client = Client(public=True)


    # Get codelist of Phenotype

    phenotype_codelist = client.phenotypes.get_codelist(
     'PH3422',
     version_id=8458
    )

  7. Version History

    Version IDNameOwnerPublish date
    First Generation Antipsychotics excluding long acting depots DM&D ieuan.scanlon2026-01-26 23:16