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Anxiolitics

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Drug
ID
PH362
Version ID
724
Data Sources
Valid event data range
01/01/2001 - 31/12/2013
Sex
Female, Male
Agreement Date
2017-05-01
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

PURPOSE:

Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves.

METHODS:

During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice.

RESULTS:

We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for allcause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide.

CONCLUSIONS:

Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Premature Death Among Primary Care Patients With a History of Self-Harm. Annals of Family Medicine, 15(3), 2017.

Clinical Code List

Rows: 40
Code Description Entity type Coding System (Multilex) Category
39801020 Zimovane 7.5mg tablets (Lexon (UK) Ltd) res41: Anxiolitics Multilex drug
479021 Zopiclone 3.75mg/5ml oral solution res41: Anxiolitics Multilex drug
59209020 Zopiclone 7.5mg tablets (Actavis UK Ltd) res41: Anxiolitics Multilex drug
59210020 Zopiclone 3.75mg tablets (Actavis UK Ltd) res41: Anxiolitics Multilex drug
59236020 Zopiclone 3.75mg tablets (IVAX Pharmaceuticals UK Ltd) res41: Anxiolitics Multilex drug
59237020 Zopiclone 7.5mg tablets (IVAX Pharmaceuticals UK Ltd) res41: Anxiolitics Multilex drug
59593020 Zopiclone 3.75mg tablets (Teva UK Ltd) res41: Anxiolitics Multilex drug
59594020 Zopiclone 7.5mg tablets (Teva UK Ltd) res41: Anxiolitics Multilex drug
59784020 Zopiclone 7.5mg tablets (Generics (UK) Ltd) res41: Anxiolitics Multilex drug
59785020 Zopiclone 3.75mg tablets (Generics (UK) Ltd) res41: Anxiolitics Multilex drug
60509020 Zopiclone 3.75mg tablets (A A H Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
60510020 Zopiclone 7.5mg tablets (A A H Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
62715020 Zopiclone 7.5mg tablets (Sandoz Ltd) res41: Anxiolitics Multilex drug
63436020 Zopiclone 7.5mg tablets (Kent Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
63765020 Zopiclone 7.5mg tablets (PLIVA Pharma Ltd) res41: Anxiolitics Multilex drug
63881020 Zolpidem 5mg Tablet (Winthrop Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
63882020 Zolpidem 10mg Tablet (Winthrop Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
64484020 Zolpidem 5mg tablets (Teva UK Ltd) res41: Anxiolitics Multilex drug
64487020 Zolpidem 10mg tablets (Teva UK Ltd) res41: Anxiolitics Multilex drug
64733020 Zolpidem 5mg tablets (A A H Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
64738020 Zolpidem 10mg tablets (A A H Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
65546020 Zopiclone 3.75mg tablets (Kent Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
65832020 Zolpidem 5mg tablets (IVAX Pharmaceuticals UK Ltd) res41: Anxiolitics Multilex drug
65835020 Zolpidem 10mg tablets (IVAX Pharmaceuticals UK Ltd) res41: Anxiolitics Multilex drug
66946020 Zolpidem 10mg tablets (Generics (UK) Ltd) res41: Anxiolitics Multilex drug
72408020 Zimovane 7.5mg tablets (Sanofi) res41: Anxiolitics Multilex drug
72416020 Zopiclone 7.5mg tablets res41: Anxiolitics Multilex drug
72417020 Zopiclone 3.75mg tablets res41: Anxiolitics Multilex drug
75692020 Zolpidem 5mg tablets res41: Anxiolitics Multilex drug
75693020 Zolpidem 10mg tablets res41: Anxiolitics Multilex drug
75696020 Stilnoct 5mg tablets (Sanofi) res41: Anxiolitics Multilex drug
75697020 Stilnoct 10mg tablets (Sanofi) res41: Anxiolitics Multilex drug
83069020 Zimovane LS 3.75mg tablets (Sanofi) res41: Anxiolitics Multilex drug
85821020 Zileze 3.75 tablets (Opus Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
85822020 Zileze 7.5 tablets (Opus Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
86240020 Zaleplon 5mg capsules res41: Anxiolitics Multilex drug
86241020 Zaleplon 10mg capsules res41: Anxiolitics Multilex drug
86243020 Sonata 5mg capsules (Meda Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
86244020 Sonata 10mg capsules (Meda Pharmaceuticals Ltd) res41: Anxiolitics Multilex drug
91009020 Zopiclone 3.75mg/5ml oral suspension res41: Anxiolitics Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH362/version/724/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH362/version/724/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH362', '724', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH362/version/724/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH362/version/724/export/codes/?format=json
CSV site_root/phenotypes/PH362/version/724/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH362', '724', api_client=client)

Version History

Version
ID
Name Owner Publish date
724 Anxiolitics ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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