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Atypical APDs

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Drug
ID
PH364
Version ID
728
Data Sources
Valid event data range
01/01/2001 - 31/12/2013
Sex
Female, Male
Agreement Date
2017-05-01
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

PURPOSE:

Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves.

METHODS:

During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice.

RESULTS:

We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for allcause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide.

CONCLUSIONS:

Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Premature Death Among Primary Care Patients With a History of Self-Harm. Annals of Family Medicine, 15(3), 2017.

Clinical Code List

Rows: 173
Code Description Entity type Coding System (Multilex) Category
10469020 Abilify 5mg tablets (Sigma Pharmaceuticals Plc) res41: Atypical APDs Multilex drug
13768020 Risperdal Consta 50mg powder and solvent for suspension for injection vials (Waymade Healthcare Plc) res41: Atypical APDs Multilex drug
209021 Quetiapine 12.5mg/5ml oral solution res41: Atypical APDs Multilex drug
33610020 Quetiapine 25mg/5ml oral solution res41: Atypical APDs Multilex drug
337021 Asenapine 5mg sublingual tablets sugar free res41: Atypical APDs Multilex drug
341021 Asenapine 10mg sublingual tablets sugar free res41: Atypical APDs Multilex drug
35008020 Amisulpride 12.5mg/5ml oral solution res41: Atypical APDs Multilex drug
35010020 Amisulpride 12.5mg/5ml oral suspension res41: Atypical APDs Multilex drug
3580020 Olanzapine 2.5mg tablets (Aspire Pharma Ltd) res41: Atypical APDs Multilex drug
36328020 Quetiapine 50mg/5ml oral suspension res41: Atypical APDs Multilex drug
36905020 Risperidone 125micrograms/5ml oral solution res41: Atypical APDs Multilex drug
411021 Amisulpride 25mg/5ml oral solution res41: Atypical APDs Multilex drug
42176020 Quetiapine 25mg tablets (Zentiva) res41: Atypical APDs Multilex drug
447021 Quetiapine 12.5mg/5ml oral suspension res41: Atypical APDs Multilex drug
49437020 Risperdal 1mg tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
49438020 Risperdal 2mg tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
49439020 Risperdal 3mg tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
49489020 Risperidone 4mg tablets res41: Atypical APDs Multilex drug
49490020 Risperidone 1mg/ml oral solution sugar free res41: Atypical APDs Multilex drug
49491020 Risperidone 6mg tablets res41: Atypical APDs Multilex drug
50780020 Zotepine 25mg tablets res41: Atypical APDs Multilex drug
50781020 Zotepine 50mg tablets res41: Atypical APDs Multilex drug
50782020 Zotepine 100mg tablets res41: Atypical APDs Multilex drug
53727020 Risperidone 1mg tablets res41: Atypical APDs Multilex drug
53728020 Risperidone 2mg tablets res41: Atypical APDs Multilex drug
53729020 Risperidone 3mg tablets res41: Atypical APDs Multilex drug
55209020 Zoleptil 25 tablets (Movianto UK Ltd) res41: Atypical APDs Multilex drug
55210020 Zoleptil 50 tablets (Movianto UK Ltd) res41: Atypical APDs Multilex drug
55972020 Olanzapine 15mg Orodispersible tablet res41: Atypical APDs Multilex drug
58203020 Zyprexa 15mg tablets (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
589021 Zalasta 5mg orodispersible tablets (Consilient Health Ltd) res41: Atypical APDs Multilex drug
59434020 Olanzapine 15mg tablets res41: Atypical APDs Multilex drug
65788020 Risperidone 50mg powder and solvent for suspension for injection vials res41: Atypical APDs Multilex drug
68217020 Amisulpride 50mg tablets (Zentiva) res41: Atypical APDs Multilex drug
68222020 Amisulpride 100mg tablets (Zentiva) res41: Atypical APDs Multilex drug
68224020 Amisulpride 200mg tablets (Zentiva) res41: Atypical APDs Multilex drug
69302020 Amisulpride 200mg tablets (A A H Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
709021 Olanzapine 5mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
711021 Olanzapine 5mg orodispersible tablets res41: Atypical APDs Multilex drug
713021 Olanzapine 5mg oral lyophilisates sugar free res41: Atypical APDs Multilex drug
715021 Olanzapine 10mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
717021 Olanzapine 10mg orodispersible tablets res41: Atypical APDs Multilex drug
719021 Olanzapine 10mg oral lyophilisates sugar free res41: Atypical APDs Multilex drug
723021 Olanzapine 15mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
725021 Olanzapine 15mg orodispersible tablets res41: Atypical APDs Multilex drug
72576020 Clozaril 25mg tablets (Novartis Pharmaceuticals UK Ltd) res41: Atypical APDs Multilex drug
72577020 Clozaril 100mg tablets (Novartis Pharmaceuticals UK Ltd) res41: Atypical APDs Multilex drug
72580020 Clozapine 25mg tablets res41: Atypical APDs Multilex drug
72581020 Clozapine 100mg tablets res41: Atypical APDs Multilex drug
727021 Olanzapine 15mg oral lyophilisates sugar free res41: Atypical APDs Multilex drug
729021 Olanzapine 20mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
731021 Olanzapine 20mg orodispersible tablets res41: Atypical APDs Multilex drug
733021 Olanzapine 20mg oral lyophilisates sugar free res41: Atypical APDs Multilex drug
73439020 Remoxipride 150mg capsule res41: Atypical APDs Multilex drug
73440020 Remoxipride 300mg capsule res41: Atypical APDs Multilex drug
73441020 Remoxipride 75mg capsule res41: Atypical APDs Multilex drug
73474020 Roxiam 150mg Capsule (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
73475020 Roxiam 300mg Capsule (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
73798020 Risperdal 4mg tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
73799020 Risperdal 1mg/ml liquid (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
73800020 Risperdal 6mg tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
74786020 Risperidone 500microgram tablets (Actavis UK Ltd) res41: Atypical APDs Multilex drug
74841020 Risperidone 1mg tablets (Teva UK Ltd) res41: Atypical APDs Multilex drug
74927020 Risperidone 500microgram tablets (A A H Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
77501020 Risperdal Quicklet 2mg orodispersible tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
77550020 Risperdal Consta 37.5mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
77749020 Risperdal 500microgram tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
77912020 Risperidone 500microgram tablets res41: Atypical APDs Multilex drug
78753020 Risperdal Consta 25mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
78912020 Zyprexa 5mg Velotabs (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
78913020 Zyprexa 10mg Velotabs (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
79348020 Solian 100mg/ml oral solution (Sanofi) res41: Atypical APDs Multilex drug
79476020 Risperidone 1mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
79499020 Zyprexa 15mg Velotabs (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
80139020 Amisulpride 100mg tablets res41: Atypical APDs Multilex drug
80154020 Solian 100 tablets (Sanofi) res41: Atypical APDs Multilex drug
81008020 Zyprexa 2.5mg tablets (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
81014020 Olanzapine 2.5mg tablets res41: Atypical APDs Multilex drug
81015020 Olanzapine 5mg Orodispersible tablet res41: Atypical APDs Multilex drug
81016020 Olanzapine 10mg Orodispersible tablet res41: Atypical APDs Multilex drug
81543020 Risperidone 2mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
81545020 Risperdal Quicklet 1mg orodispersible tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
81945020 Amisulpride 100mg/ml oral solution sugar free res41: Atypical APDs Multilex drug
82616020 Risperdal Consta 50mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
82827020 Sertindole 4mg tablets res41: Atypical APDs Multilex drug
82828020 Sertindole 12mg tablets res41: Atypical APDs Multilex drug
82829020 Sertindole 16mg tablets res41: Atypical APDs Multilex drug
82831020 Sertindole 20mg tablets res41: Atypical APDs Multilex drug
82835020 Serdolect 4mg tablets (Lundbeck Ltd) res41: Atypical APDs Multilex drug
82836020 Serdolect 12mg tablets (Lundbeck Ltd) res41: Atypical APDs Multilex drug
82837020 Serdolect 16mg tablets (Lundbeck Ltd) res41: Atypical APDs Multilex drug
83397020 Zyprexa 5mg tablets (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
83398020 Zyprexa 7.5mg tablets (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
83399020 Zyprexa 10mg tablets (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
83403020 Olanzapine 5mg tablets res41: Atypical APDs Multilex drug
83404020 Olanzapine 7.5mg tablets res41: Atypical APDs Multilex drug
83405020 Olanzapine 10mg tablets res41: Atypical APDs Multilex drug
84528020 Roxiam ir 75mg Capsule (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
85202020 Quetiapine Starter Pack res41: Atypical APDs Multilex drug
85203020 Quetiapine 25mg tablets res41: Atypical APDs Multilex drug
85204020 Quetiapine 100mg tablets res41: Atypical APDs Multilex drug
85206020 Quetiapine 200mg tablets res41: Atypical APDs Multilex drug
85207020 Quetiapine 150mg tablets res41: Atypical APDs Multilex drug
85212020 Seroquel 25mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
85213020 Seroquel 100mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
85215020 Seroquel 200mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
85216020 Seroquel 150mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
85992020 Amisulpride 50mg tablets res41: Atypical APDs Multilex drug
85993020 Amisulpride 200mg tablets res41: Atypical APDs Multilex drug
85994020 Amisulpride 400mg tablets res41: Atypical APDs Multilex drug
85999020 Solian 50 tablets (Sanofi) res41: Atypical APDs Multilex drug
86000020 Solian 200 tablets (Sanofi) res41: Atypical APDs Multilex drug
86001020 Solian 400 tablets (Sanofi) res41: Atypical APDs Multilex drug
86494020 Risperidone 25mg powder and solvent for suspension for injection vials res41: Atypical APDs Multilex drug
86496020 Risperidone 37.5mg powder and solvent for suspension for injection vials res41: Atypical APDs Multilex drug
87045020 Quetiapine 300mg tablets res41: Atypical APDs Multilex drug
87047020 Seroquel 300mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
87556020 Olanzapine 10mg powder for solution for injection vials res41: Atypical APDs Multilex drug
87558020 Zyprexa 10mg powder for solution for injection vials (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
87944020 Aripiprazole 10mg tablets res41: Atypical APDs Multilex drug
87946020 Aripiprazole 15mg tablets res41: Atypical APDs Multilex drug
87948020 Aripiprazole 30mg tablets res41: Atypical APDs Multilex drug
87950020 Abilify 10mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
87952020 Abilify 15mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
87954020 Abilify 30mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
88167020 Denzapine 25mg tablets (Britannia Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
88169020 Denzapine 100mg tablets (Britannia Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
88666020 Aripiprazole 5mg tablets res41: Atypical APDs Multilex drug
88668020 Abilify 5mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
88804020 Zaponex 25mg tablets (Teva UK Ltd) res41: Atypical APDs Multilex drug
88806020 Zaponex 100mg tablets (Teva UK Ltd) res41: Atypical APDs Multilex drug
88875020 Risperidone 500microgram orodispersible tablets sugar free res41: Atypical APDs Multilex drug
88877020 Risperdal Quicklet 500microgram orodispersible tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
89950020 Amisulpride 25mg/5ml oral suspension res41: Atypical APDs Multilex drug
90165020 Olanzapine 20mg Orodispersible tablet res41: Atypical APDs Multilex drug
90167020 Zyprexa 20mg Velotabs (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
91139020 Aripiprazole 10mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
91141020 Aripiprazole 15mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
91143020 Aripiprazole 1mg/ml oral solution res41: Atypical APDs Multilex drug
91145020 Abilify 10mg orodispersible tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
91147020 Abilify 15mg orodispersible tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
91149020 Abilify 1mg/ml oral solution (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
92053020 Olanzapine 20mg tablets res41: Atypical APDs Multilex drug
92055020 Zyprexa 20mg tablets (Eli Lilly and Company Ltd) res41: Atypical APDs Multilex drug
92717020 Risperidone 3mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
92721020 Risperidone 4mg orodispersible tablets sugar free res41: Atypical APDs Multilex drug
92723020 Risperdal Quicklet 3mg orodispersible tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
92725020 Risperdal Quicklet 4mg orodispersible tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
93739020 Paliperidone 3mg modified-release tablets res41: Atypical APDs Multilex drug
93741020 Paliperidone 6mg modified-release tablets res41: Atypical APDs Multilex drug
93743020 Paliperidone 9mg modified-release tablets res41: Atypical APDs Multilex drug
93747020 Invega 6mg modified-release tablets (Janssen-Cilag Ltd) res41: Atypical APDs Multilex drug
94787020 Quetiapine 50mg modified-release tablets res41: Atypical APDs Multilex drug
94789020 Quetiapine 200mg modified-release tablets res41: Atypical APDs Multilex drug
94791020 Quetiapine 300mg modified-release tablets res41: Atypical APDs Multilex drug
94793020 Quetiapine 400mg modified-release tablets res41: Atypical APDs Multilex drug
94971020 Aripiprazole 9.75mg/1.3ml solution for injection vials res41: Atypical APDs Multilex drug
94973020 Abilify 9.75mg/1.3ml solution for injection vials (Otsuka Pharmaceuticals (U.K.) Ltd) res41: Atypical APDs Multilex drug
95787020 Seroquel XL 50mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
95789020 Seroquel XL 200mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
95791020 Seroquel XL 300mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
95793020 Seroquel XL 400mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
97145020 Clozapine 50mg tablets res41: Atypical APDs Multilex drug
97147020 Denzapine 50mg tablets (Britannia Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
97149020 Clozapine 200mg tablets res41: Atypical APDs Multilex drug
97151020 Denzapine 200mg tablets (Britannia Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
97153020 Clozapine 50mg/ml oral suspension sugar free res41: Atypical APDs Multilex drug
97155020 Denzapine 50mg/ml oral suspension (Britannia Pharmaceuticals Ltd) res41: Atypical APDs Multilex drug
97203020 Quetiapine 100mg/5ml oral solution res41: Atypical APDs Multilex drug
97205020 Quetiapine 100mg/5ml oral suspension res41: Atypical APDs Multilex drug
98873020 Quetiapine 150mg modified-release tablets res41: Atypical APDs Multilex drug
98875020 Seroquel XL 150mg tablets (AstraZeneca UK Ltd) res41: Atypical APDs Multilex drug
99745020 Quetiapine 25mg/5ml oral suspension res41: Atypical APDs Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH364/version/728/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH364/version/728/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH364', '728', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH364/version/728/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH364/version/728/export/codes/?format=json
CSV site_root/phenotypes/PH364/version/728/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH364', '728', api_client=client)

Version History

Version
ID
Name Owner Publish date
728 Atypical APDs ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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