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Atypical APDs

Matthew J Carr, Darren M Ashscroft, Evangelos Kontopantelis, David While, Yvonne Awenant, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Drug
ID
PH365
Version ID
730
Data Sources
Valid event data range
01/01/2001 - 31/12/2012
Sex
Female, Male
Agreement Date
2016-03-08
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Background:

Little is known about the clinical management of patients in primary care following self-harm.

Methods:

A descriptive cohort study using data from 684 UK general practices that contributed to the Clinical Practice Research Datalink (CPRD) during 2001-2013. We identified 49,970 patients with a self-harm episode, 41,500 of whom had one complete year of follow-up.

Results:

Among those with complete follow-up, 26,065 (62.8%, 62.3-63.3) were prescribed psychotropic medication and 6318 (15.2%, 14.9-15.6) were referred to mental health services; 4105 (9.9%, CI 9.6-10.2) were medicated without an antecedent psychiatric diagnosis or referral, and 4,506 (10.9%, CI 10.6-11.2) had a diagnosis but were not subsequently medicated or referred. Patients registered at practices in the most deprived localities were 27.1% (CI 21.5-32.2) less likely to be referred than those in the least deprived. Despite a specifically flagged NICE 'Do not do' recommendation in 2011 against prescribing tricyclic antidepressants following self-harm because of their potentially lethal toxicity in overdose, 8.8% (CI 7.8-9.8) of individuals were issued a prescription in the subsequent year. The percentage prescribed Citalopram, an SSRI antidepressant with higher toxicity in overdose, fell sharply during 2012/2013 in the aftermath of a Medicines and Healthcare products Regulatory Agency (MHRA) safety alert issued in 2011.

Conclusions:

A relatively small percentage of these vulnerable patients are referred to mental health services, and reduced likelihood of referral in more deprived localities reflects a marked health inequality. National clinical guidelines have not yet been effective in reducing rates of tricyclic antidepressant prescribing for this high-risk group.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenant, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Clinical management following self-harm in a UK-wide primary care cohort. Journal of Affective Disorders, 197(2016) 182-188, 2016.

Clinical Code List

Rows: 173
Code Description Entity type Coding System (Multilex) Category
10469020 Abilify 5mg tablets (Sigma Pharmaceuticals Plc) res36: Atypical APDs Multilex drug
13768020 Risperdal Consta 50mg powder and solvent for suspension for injection vials (Waymade Healthcare Plc) res36: Atypical APDs Multilex drug
209021 Quetiapine 12.5mg/5ml oral solution res36: Atypical APDs Multilex drug
33610020 Quetiapine 25mg/5ml oral solution res36: Atypical APDs Multilex drug
337021 Asenapine 5mg sublingual tablets sugar free res36: Atypical APDs Multilex drug
341021 Asenapine 10mg sublingual tablets sugar free res36: Atypical APDs Multilex drug
35008020 Amisulpride 12.5mg/5ml oral solution res36: Atypical APDs Multilex drug
35010020 Amisulpride 12.5mg/5ml oral suspension res36: Atypical APDs Multilex drug
3580020 Olanzapine 2.5mg tablets (Aspire Pharma Ltd) res36: Atypical APDs Multilex drug
36328020 Quetiapine 50mg/5ml oral suspension res36: Atypical APDs Multilex drug
36905020 Risperidone 125micrograms/5ml oral solution res36: Atypical APDs Multilex drug
411021 Amisulpride 25mg/5ml oral solution res36: Atypical APDs Multilex drug
42176020 Quetiapine 25mg tablets (Zentiva) res36: Atypical APDs Multilex drug
447021 Quetiapine 12.5mg/5ml oral suspension res36: Atypical APDs Multilex drug
49437020 Risperdal 1mg tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
49438020 Risperdal 2mg tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
49439020 Risperdal 3mg tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
49489020 Risperidone 4mg tablets res36: Atypical APDs Multilex drug
49490020 Risperidone 1mg/ml oral solution sugar free res36: Atypical APDs Multilex drug
49491020 Risperidone 6mg tablets res36: Atypical APDs Multilex drug
50780020 Zotepine 25mg tablets res36: Atypical APDs Multilex drug
50781020 Zotepine 50mg tablets res36: Atypical APDs Multilex drug
50782020 Zotepine 100mg tablets res36: Atypical APDs Multilex drug
53727020 Risperidone 1mg tablets res36: Atypical APDs Multilex drug
53728020 Risperidone 2mg tablets res36: Atypical APDs Multilex drug
53729020 Risperidone 3mg tablets res36: Atypical APDs Multilex drug
55209020 Zoleptil 25 tablets (Movianto UK Ltd) res36: Atypical APDs Multilex drug
55210020 Zoleptil 50 tablets (Movianto UK Ltd) res36: Atypical APDs Multilex drug
55972020 Olanzapine 15mg Orodispersible tablet res36: Atypical APDs Multilex drug
58203020 Zyprexa 15mg tablets (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
589021 Zalasta 5mg orodispersible tablets (Consilient Health Ltd) res36: Atypical APDs Multilex drug
59434020 Olanzapine 15mg tablets res36: Atypical APDs Multilex drug
65788020 Risperidone 50mg powder and solvent for suspension for injection vials res36: Atypical APDs Multilex drug
68217020 Amisulpride 50mg tablets (Zentiva) res36: Atypical APDs Multilex drug
68222020 Amisulpride 100mg tablets (Zentiva) res36: Atypical APDs Multilex drug
68224020 Amisulpride 200mg tablets (Zentiva) res36: Atypical APDs Multilex drug
69302020 Amisulpride 200mg tablets (A A H Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
709021 Olanzapine 5mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
711021 Olanzapine 5mg orodispersible tablets res36: Atypical APDs Multilex drug
713021 Olanzapine 5mg oral lyophilisates sugar free res36: Atypical APDs Multilex drug
715021 Olanzapine 10mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
717021 Olanzapine 10mg orodispersible tablets res36: Atypical APDs Multilex drug
719021 Olanzapine 10mg oral lyophilisates sugar free res36: Atypical APDs Multilex drug
723021 Olanzapine 15mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
725021 Olanzapine 15mg orodispersible tablets res36: Atypical APDs Multilex drug
72576020 Clozaril 25mg tablets (Novartis Pharmaceuticals UK Ltd) res36: Atypical APDs Multilex drug
72577020 Clozaril 100mg tablets (Novartis Pharmaceuticals UK Ltd) res36: Atypical APDs Multilex drug
72580020 Clozapine 25mg tablets res36: Atypical APDs Multilex drug
72581020 Clozapine 100mg tablets res36: Atypical APDs Multilex drug
727021 Olanzapine 15mg oral lyophilisates sugar free res36: Atypical APDs Multilex drug
729021 Olanzapine 20mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
731021 Olanzapine 20mg orodispersible tablets res36: Atypical APDs Multilex drug
733021 Olanzapine 20mg oral lyophilisates sugar free res36: Atypical APDs Multilex drug
73439020 Remoxipride 150mg capsule res36: Atypical APDs Multilex drug
73440020 Remoxipride 300mg capsule res36: Atypical APDs Multilex drug
73441020 Remoxipride 75mg capsule res36: Atypical APDs Multilex drug
73474020 Roxiam 150mg Capsule (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
73475020 Roxiam 300mg Capsule (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
73798020 Risperdal 4mg tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
73799020 Risperdal 1mg/ml liquid (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
73800020 Risperdal 6mg tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
74786020 Risperidone 500microgram tablets (Actavis UK Ltd) res36: Atypical APDs Multilex drug
74841020 Risperidone 1mg tablets (Teva UK Ltd) res36: Atypical APDs Multilex drug
74927020 Risperidone 500microgram tablets (A A H Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
77501020 Risperdal Quicklet 2mg orodispersible tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
77550020 Risperdal Consta 37.5mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
77749020 Risperdal 500microgram tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
77912020 Risperidone 500microgram tablets res36: Atypical APDs Multilex drug
78753020 Risperdal Consta 25mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
78912020 Zyprexa 5mg Velotabs (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
78913020 Zyprexa 10mg Velotabs (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
79348020 Solian 100mg/ml oral solution (Sanofi) res36: Atypical APDs Multilex drug
79476020 Risperidone 1mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
79499020 Zyprexa 15mg Velotabs (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
80139020 Amisulpride 100mg tablets res36: Atypical APDs Multilex drug
80154020 Solian 100 tablets (Sanofi) res36: Atypical APDs Multilex drug
81008020 Zyprexa 2.5mg tablets (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
81014020 Olanzapine 2.5mg tablets res36: Atypical APDs Multilex drug
81015020 Olanzapine 5mg Orodispersible tablet res36: Atypical APDs Multilex drug
81016020 Olanzapine 10mg Orodispersible tablet res36: Atypical APDs Multilex drug
81543020 Risperidone 2mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
81545020 Risperdal Quicklet 1mg orodispersible tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
81945020 Amisulpride 100mg/ml oral solution sugar free res36: Atypical APDs Multilex drug
82616020 Risperdal Consta 50mg powder and solvent for suspension for injection vials (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
82827020 Sertindole 4mg tablets res36: Atypical APDs Multilex drug
82828020 Sertindole 12mg tablets res36: Atypical APDs Multilex drug
82829020 Sertindole 16mg tablets res36: Atypical APDs Multilex drug
82831020 Sertindole 20mg tablets res36: Atypical APDs Multilex drug
82835020 Serdolect 4mg tablets (Lundbeck Ltd) res36: Atypical APDs Multilex drug
82836020 Serdolect 12mg tablets (Lundbeck Ltd) res36: Atypical APDs Multilex drug
82837020 Serdolect 16mg tablets (Lundbeck Ltd) res36: Atypical APDs Multilex drug
83397020 Zyprexa 5mg tablets (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
83398020 Zyprexa 7.5mg tablets (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
83399020 Zyprexa 10mg tablets (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
83403020 Olanzapine 5mg tablets res36: Atypical APDs Multilex drug
83404020 Olanzapine 7.5mg tablets res36: Atypical APDs Multilex drug
83405020 Olanzapine 10mg tablets res36: Atypical APDs Multilex drug
84528020 Roxiam ir 75mg Capsule (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
85202020 Quetiapine Starter Pack res36: Atypical APDs Multilex drug
85203020 Quetiapine 25mg tablets res36: Atypical APDs Multilex drug
85204020 Quetiapine 100mg tablets res36: Atypical APDs Multilex drug
85206020 Quetiapine 200mg tablets res36: Atypical APDs Multilex drug
85207020 Quetiapine 150mg tablets res36: Atypical APDs Multilex drug
85212020 Seroquel 25mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
85213020 Seroquel 100mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
85215020 Seroquel 200mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
85216020 Seroquel 150mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
85992020 Amisulpride 50mg tablets res36: Atypical APDs Multilex drug
85993020 Amisulpride 200mg tablets res36: Atypical APDs Multilex drug
85994020 Amisulpride 400mg tablets res36: Atypical APDs Multilex drug
85999020 Solian 50 tablets (Sanofi) res36: Atypical APDs Multilex drug
86000020 Solian 200 tablets (Sanofi) res36: Atypical APDs Multilex drug
86001020 Solian 400 tablets (Sanofi) res36: Atypical APDs Multilex drug
86494020 Risperidone 25mg powder and solvent for suspension for injection vials res36: Atypical APDs Multilex drug
86496020 Risperidone 37.5mg powder and solvent for suspension for injection vials res36: Atypical APDs Multilex drug
87045020 Quetiapine 300mg tablets res36: Atypical APDs Multilex drug
87047020 Seroquel 300mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
87556020 Olanzapine 10mg powder for solution for injection vials res36: Atypical APDs Multilex drug
87558020 Zyprexa 10mg powder for solution for injection vials (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
87944020 Aripiprazole 10mg tablets res36: Atypical APDs Multilex drug
87946020 Aripiprazole 15mg tablets res36: Atypical APDs Multilex drug
87948020 Aripiprazole 30mg tablets res36: Atypical APDs Multilex drug
87950020 Abilify 10mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
87952020 Abilify 15mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
87954020 Abilify 30mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
88167020 Denzapine 25mg tablets (Britannia Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
88169020 Denzapine 100mg tablets (Britannia Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
88666020 Aripiprazole 5mg tablets res36: Atypical APDs Multilex drug
88668020 Abilify 5mg tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
88804020 Zaponex 25mg tablets (Teva UK Ltd) res36: Atypical APDs Multilex drug
88806020 Zaponex 100mg tablets (Teva UK Ltd) res36: Atypical APDs Multilex drug
88875020 Risperidone 500microgram orodispersible tablets sugar free res36: Atypical APDs Multilex drug
88877020 Risperdal Quicklet 500microgram orodispersible tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
89950020 Amisulpride 25mg/5ml oral suspension res36: Atypical APDs Multilex drug
90165020 Olanzapine 20mg Orodispersible tablet res36: Atypical APDs Multilex drug
90167020 Zyprexa 20mg Velotabs (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
91139020 Aripiprazole 10mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
91141020 Aripiprazole 15mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
91143020 Aripiprazole 1mg/ml oral solution res36: Atypical APDs Multilex drug
91145020 Abilify 10mg orodispersible tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
91147020 Abilify 15mg orodispersible tablets (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
91149020 Abilify 1mg/ml oral solution (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
92053020 Olanzapine 20mg tablets res36: Atypical APDs Multilex drug
92055020 Zyprexa 20mg tablets (Eli Lilly and Company Ltd) res36: Atypical APDs Multilex drug
92717020 Risperidone 3mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
92721020 Risperidone 4mg orodispersible tablets sugar free res36: Atypical APDs Multilex drug
92723020 Risperdal Quicklet 3mg orodispersible tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
92725020 Risperdal Quicklet 4mg orodispersible tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
93739020 Paliperidone 3mg modified-release tablets res36: Atypical APDs Multilex drug
93741020 Paliperidone 6mg modified-release tablets res36: Atypical APDs Multilex drug
93743020 Paliperidone 9mg modified-release tablets res36: Atypical APDs Multilex drug
93747020 Invega 6mg modified-release tablets (Janssen-Cilag Ltd) res36: Atypical APDs Multilex drug
94787020 Quetiapine 50mg modified-release tablets res36: Atypical APDs Multilex drug
94789020 Quetiapine 200mg modified-release tablets res36: Atypical APDs Multilex drug
94791020 Quetiapine 300mg modified-release tablets res36: Atypical APDs Multilex drug
94793020 Quetiapine 400mg modified-release tablets res36: Atypical APDs Multilex drug
94971020 Aripiprazole 9.75mg/1.3ml solution for injection vials res36: Atypical APDs Multilex drug
94973020 Abilify 9.75mg/1.3ml solution for injection vials (Otsuka Pharmaceuticals (U.K.) Ltd) res36: Atypical APDs Multilex drug
95787020 Seroquel XL 50mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
95789020 Seroquel XL 200mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
95791020 Seroquel XL 300mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
95793020 Seroquel XL 400mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
97145020 Clozapine 50mg tablets res36: Atypical APDs Multilex drug
97147020 Denzapine 50mg tablets (Britannia Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
97149020 Clozapine 200mg tablets res36: Atypical APDs Multilex drug
97151020 Denzapine 200mg tablets (Britannia Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
97153020 Clozapine 50mg/ml oral suspension sugar free res36: Atypical APDs Multilex drug
97155020 Denzapine 50mg/ml oral suspension (Britannia Pharmaceuticals Ltd) res36: Atypical APDs Multilex drug
97203020 Quetiapine 100mg/5ml oral solution res36: Atypical APDs Multilex drug
97205020 Quetiapine 100mg/5ml oral suspension res36: Atypical APDs Multilex drug
98873020 Quetiapine 150mg modified-release tablets res36: Atypical APDs Multilex drug
98875020 Seroquel XL 150mg tablets (AstraZeneca UK Ltd) res36: Atypical APDs Multilex drug
99745020 Quetiapine 25mg/5ml oral suspension res36: Atypical APDs Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH365/version/730/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH365/version/730/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH365', '730', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH365/version/730/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH365/version/730/export/codes/?format=json
CSV site_root/phenotypes/PH365/version/730/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH365', '730', api_client=client)

Version History

Version
ID
Name Owner Publish date
730 Atypical APDs ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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