Print

Bipolar Disorder

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Disease or Syndrome
ID
PH368
Version ID
736
Data Sources
Valid event data range
01/01/2001 - 31/12/2013
Sex
Female, Male
Agreement Date
2017-05-01
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

PURPOSE:

Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves.

METHODS:

During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice.

RESULTS:

We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for allcause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide.

CONCLUSIONS:

Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Premature Death Among Primary Care Patients With a History of Self-Harm. Annals of Family Medicine, 15(3), 2017.

Clinical Code List

Rows: 111
Code Description Entity type Category Coding System (Read)
146D.00 H/O: manic depressive disorder res41: Bipolar disorder diagnostic Read
1S42.00 Manic mood res41: Bipolar disorder diagnostic Read
6657.00 On lithium res41: Bipolar disorder diagnostic Read
6657.11 Lithium monitoring res41: Bipolar disorder diagnostic Read
6657.12 Started lithium res41: Bipolar disorder diagnostic Read
E11..00 Affective psychoses res41: Bipolar disorder diagnostic Read
E11..11 Bipolar psychoses res41: Bipolar disorder diagnostic Read
E11..13 Manic psychoses res41: Bipolar disorder diagnostic Read
E110.00 Manic disorder, single episode res41: Bipolar disorder diagnostic Read
E110.11 Hypomanic psychoses res41: Bipolar disorder diagnostic Read
E110000 Single manic episode, unspecified res41: Bipolar disorder diagnostic Read
E110100 Single manic episode, mild res41: Bipolar disorder diagnostic Read
E110200 Single manic episode, moderate res41: Bipolar disorder diagnostic Read
E110300 Single manic episode, severe without mention of psychosis res41: Bipolar disorder diagnostic Read
E110400 Single manic episode, severe, with psychosis res41: Bipolar disorder diagnostic Read
E110600 Single manic episode in full remission res41: Bipolar disorder diagnostic Read
E110z00 Manic disorder, single episode NOS res41: Bipolar disorder diagnostic Read
E111.00 Recurrent manic episodes res41: Bipolar disorder diagnostic Read
E111000 Recurrent manic episodes, unspecified res41: Bipolar disorder diagnostic Read
E111100 Recurrent manic episodes, mild res41: Bipolar disorder diagnostic Read
E111200 Recurrent manic episodes, moderate res41: Bipolar disorder diagnostic Read
E111300 Recurrent manic episodes, severe without mention psychosis res41: Bipolar disorder diagnostic Read
E111400 Recurrent manic episodes, severe, with psychosis res41: Bipolar disorder diagnostic Read
E111500 Recurrent manic episodes, partial or unspecified remission res41: Bipolar disorder diagnostic Read
E111600 Recurrent manic episodes, in full remission res41: Bipolar disorder diagnostic Read
E111z00 Recurrent manic episode NOS res41: Bipolar disorder diagnostic Read
E114.00 Bipolar affective disorder, currently manic res41: Bipolar disorder diagnostic Read
E114.11 Manic-depressive - now manic res41: Bipolar disorder diagnostic Read
E114000 Bipolar affective disorder, currently manic, unspecified res41: Bipolar disorder diagnostic Read
E114100 Bipolar affective disorder, currently manic, mild res41: Bipolar disorder diagnostic Read
E114200 Bipolar affective disorder, currently manic, moderate res41: Bipolar disorder diagnostic Read
E114300 Bipolar affect disord, currently manic, severe, no psychosis res41: Bipolar disorder diagnostic Read
E114400 Bipolar affect disord, currently manic,severe with psychosis res41: Bipolar disorder diagnostic Read
E114500 Bipolar affect disord,currently manic, part/unspec remission res41: Bipolar disorder diagnostic Read
E114600 Bipolar affective disorder, currently manic, full remission res41: Bipolar disorder diagnostic Read
E114z00 Bipolar affective disorder, currently manic, NOS res41: Bipolar disorder diagnostic Read
E115.00 Bipolar affective disorder, currently depressed res41: Bipolar disorder diagnostic Read
E115.11 Manic-depressive - now depressed res41: Bipolar disorder diagnostic Read
E115000 Bipolar affective disorder, currently depressed, unspecified res41: Bipolar disorder diagnostic Read
E115100 Bipolar affective disorder, currently depressed, mild res41: Bipolar disorder diagnostic Read
E115200 Bipolar affective disorder, currently depressed, moderate res41: Bipolar disorder diagnostic Read
E115300 Bipolar affect disord, now depressed, severe, no psychosis res41: Bipolar disorder diagnostic Read
E115400 Bipolar affect disord, now depressed, severe with psychosis res41: Bipolar disorder diagnostic Read
E115500 Bipolar affect disord, now depressed, part/unspec remission res41: Bipolar disorder diagnostic Read
E115600 Bipolar affective disorder, now depressed, in full remission res41: Bipolar disorder diagnostic Read
E115z00 Bipolar affective disorder, currently depressed, NOS res41: Bipolar disorder diagnostic Read
E116.00 Mixed bipolar affective disorder res41: Bipolar disorder diagnostic Read
E116000 Mixed bipolar affective disorder, unspecified res41: Bipolar disorder diagnostic Read
E116100 Mixed bipolar affective disorder, mild res41: Bipolar disorder diagnostic Read
E116200 Mixed bipolar affective disorder, moderate res41: Bipolar disorder diagnostic Read
E116300 Mixed bipolar affective disorder, severe, without psychosis res41: Bipolar disorder diagnostic Read
E116400 Mixed bipolar affective disorder, severe, with psychosis res41: Bipolar disorder diagnostic Read
E116500 Mixed bipolar affective disorder, partial/unspec remission res41: Bipolar disorder diagnostic Read
E116600 Mixed bipolar affective disorder, in full remission res41: Bipolar disorder diagnostic Read
E116z00 Mixed bipolar affective disorder, NOS res41: Bipolar disorder diagnostic Read
E117.00 Unspecified bipolar affective disorder res41: Bipolar disorder diagnostic Read
E117000 Unspecified bipolar affective disorder, unspecified res41: Bipolar disorder diagnostic Read
E117100 Unspecified bipolar affective disorder, mild res41: Bipolar disorder diagnostic Read
E117200 Unspecified bipolar affective disorder, moderate res41: Bipolar disorder diagnostic Read
E117300 Unspecified bipolar affective disorder, severe, no psychosis res41: Bipolar disorder diagnostic Read
E117400 Unspecified bipolar affective disorder,severe with psychosis res41: Bipolar disorder diagnostic Read
E117500 Unspecified bipolar affect disord, partial/unspec remission res41: Bipolar disorder diagnostic Read
E117600 Unspecified bipolar affective disorder, in full remission res41: Bipolar disorder diagnostic Read
E117z00 Unspecified bipolar affective disorder, NOS res41: Bipolar disorder diagnostic Read
E11y.00 Other and unspecified manic-depressive psychoses res41: Bipolar disorder diagnostic Read
E11y000 Unspecified manic-depressive psychoses res41: Bipolar disorder diagnostic Read
E11y100 Atypical manic disorder res41: Bipolar disorder diagnostic Read
E11y300 Other mixed manic-depressive psychoses res41: Bipolar disorder diagnostic Read
E11yz00 Other and unspecified manic-depressive psychoses NOS res41: Bipolar disorder diagnostic Read
Eu3..00 [X]Mood - affective disorders res41: Bipolar disorder diagnostic Read
Eu30.00 [X]Manic episode res41: Bipolar disorder diagnostic Read
Eu30.11 [X]Bipolar disorder, single manic episode res41: Bipolar disorder diagnostic Read
Eu30000 [X]Hypomania res41: Bipolar disorder diagnostic Read
Eu30100 [X]Mania without psychotic symptoms res41: Bipolar disorder diagnostic Read
Eu30200 [X]Mania with psychotic symptoms res41: Bipolar disorder diagnostic Read
Eu30211 [X]Mania with mood-congruent psychotic symptoms res41: Bipolar disorder diagnostic Read
Eu30212 [X]Mania with mood-incongruent psychotic symptoms res41: Bipolar disorder diagnostic Read
Eu30y00 [X]Other manic episodes res41: Bipolar disorder diagnostic Read
Eu30z00 [X]Manic episode, unspecified res41: Bipolar disorder diagnostic Read
Eu30z11 [X]Mania NOS res41: Bipolar disorder diagnostic Read
Eu31.00 [X]Bipolar affective disorder res41: Bipolar disorder diagnostic Read
Eu31.11 [X]Manic-depressive illness res41: Bipolar disorder diagnostic Read
Eu31.12 [X]Manic-depressive psychosis res41: Bipolar disorder diagnostic Read
Eu31.13 [X]Manic-depressive reaction res41: Bipolar disorder diagnostic Read
Eu31000 [X]Bipolar affective disorder, current episode hypomanic res41: Bipolar disorder diagnostic Read
Eu31100 [X]Bipolar affect disorder cur epi manic wout psychotic symp res41: Bipolar disorder diagnostic Read
Eu31200 [X]Bipolar affect disorder cur epi manic with psychotic symp res41: Bipolar disorder diagnostic Read
Eu31300 [X]Bipolar affect disorder cur epi mild or moderate depressn res41: Bipolar disorder diagnostic Read
Eu31400 [X]Bipol aff disord, curr epis sev depress, no psychot symp res41: Bipolar disorder diagnostic Read
Eu31500 [X]Bipolar affect dis cur epi severe depres with psyc symp res41: Bipolar disorder diagnostic Read
Eu31600 [X]Bipolar affective disorder, current episode mixed res41: Bipolar disorder diagnostic Read
Eu31700 [X]Bipolar affective disorder, currently in remission res41: Bipolar disorder diagnostic Read
Eu31y00 [X]Other bipolar affective disorders res41: Bipolar disorder diagnostic Read
Eu31y11 [X]Bipolar II disorder res41: Bipolar disorder diagnostic Read
Eu31y12 [X]Recurrent manic episodes res41: Bipolar disorder diagnostic Read
Eu31z00 [X]Bipolar affective disorder, unspecified res41: Bipolar disorder diagnostic Read
Eu33213 [X]Manic-depress psychosis,depressd,no psychotic symptoms res41: Bipolar disorder diagnostic Read
Eu33312 [X]Manic-depress psychosis,depressed type+psychotic symptoms res41: Bipolar disorder diagnostic Read
Eu34.00 [X]Persistent mood affective disorders res41: Bipolar disorder diagnostic Read
Eu34000 [X]Cyclothymia res41: Bipolar disorder diagnostic Read
Eu34y00 [X]Other persistent mood affective disorders res41: Bipolar disorder diagnostic Read
Eu34z00 [X]Persistent mood affective disorder, unspecified res41: Bipolar disorder diagnostic Read
Eu3y.00 [X]Other mood affective disorders res41: Bipolar disorder diagnostic Read
Eu3y000 [X]Other single mood affective disorders res41: Bipolar disorder diagnostic Read
Eu3y011 [X]Mixed affective episode res41: Bipolar disorder diagnostic Read
Eu3y100 [X]Other recurrent mood affective disorders res41: Bipolar disorder diagnostic Read
Eu3yy00 [X]Other specified mood affective disorders res41: Bipolar disorder diagnostic Read
Eu3z.00 [X]Unspecified mood affective disorder res41: Bipolar disorder diagnostic Read
Eu3z.11 [X]Affective psychosis NOS res41: Bipolar disorder diagnostic Read
ZV11111 [V]Personal history of manic-depressive psychosis res41: Bipolar disorder diagnostic Read
ZV11112 [V]Personal history of manic-depressive psychosis res41: Bipolar disorder diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH368/version/736/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH368/version/736/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH368', '736', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH368/version/736/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH368/version/736/export/codes/?format=json
CSV site_root/phenotypes/PH368/version/736/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH368', '736', api_client=client)

Version History

Version
ID
Name Owner Publish date
736 Bipolar Disorder ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

Print - Print page.