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Depot APDs

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Drug
ID
PH370
Version ID
740
Data Sources
Valid event data range
01/01/2001 - 31/12/2013
Sex
Female, Male
Agreement Date
2017-05-01
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

PURPOSE:

Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves.

METHODS:

During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice.

RESULTS:

We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for allcause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide.

CONCLUSIONS:

Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Premature Death Among Primary Care Patients With a History of Self-Harm. Annals of Family Medicine, 15(3), 2017.

Clinical Code List

Rows: 56
Code Description Entity type Coding System (Multilex) Category
48900020 Depixol -conc 100mg/ml Injection (Lundbeck Ltd) res41: Depot APDs Multilex drug
50445020 Modecate 25mg/ml Injection (Sanofi-Synthelabo Ltd) res41: Depot APDs Multilex drug
53027020 Clopixol 200mg/ml Oily injection (Lundbeck Ltd) res41: Depot APDs Multilex drug
53030020 Depixol 20mg/ml Injection (Lundbeck Ltd) res41: Depot APDs Multilex drug
53031020 Depixol 40mg/2ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
53053020 Modecate concentrate 100mg/ml Injection (Sanofi-Synthelabo Ltd) res41: Depot APDs Multilex drug
53586020 Piportil 50mg/ml Depot injection (JHC Healthcare Ltd) res41: Depot APDs Multilex drug
57938020 Depixol Low Volume 200mg/1ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
58509020 Haldol decanoate 50mg/1ml solution for injection ampoules (Janssen-Cilag Ltd) res41: Depot APDs Multilex drug
58510020 Haldol decanoate 100mg/1ml solution for injection ampoules (Janssen-Cilag Ltd) res41: Depot APDs Multilex drug
61027020 Fluphenazine decanoate 25mg/1ml solution for injection ampoules (Hospira UK Ltd) res41: Depot APDs Multilex drug
61511020 Zuclopenthixol decanoate 200mg/ml oily injection res41: Depot APDs Multilex drug
61512020 Zuclopenthixol decanoate 500mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
62032020 Flupentixol decanoate 20mg/ml Injection res41: Depot APDs Multilex drug
62033020 Flupentixol decanoate 100mg/ml Injection res41: Depot APDs Multilex drug
62034020 Flupentixol 200mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
62048020 Fluphenazine decanoate 25mg/ml Injection res41: Depot APDs Multilex drug
62049020 Fluphenazine decanoate 100mg/ml Injection res41: Depot APDs Multilex drug
62954020 Fluphenazine decanoate 25mg/ml Injection (Antigen Pharmaceuticals) res41: Depot APDs Multilex drug
63123020 Haloperidol decanoate 50mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
63124020 Haloperidol decanoate 100mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
65842020 Pipotiazine palmitate 50mg/ml depot injection res41: Depot APDs Multilex drug
67405020 Clopixol Conc 500mg/1ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
68096020 Flupentixol 40mg/2ml solution for injection ampoules res41: Depot APDs Multilex drug
89970020 Flupentixol 50mg/0.5ml solution for injection ampoules res41: Depot APDs Multilex drug
89972020 Flupentixol 100mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
89974020 Depixol Conc 50mg/0.5ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
89976020 Depixol Conc 100mg/1ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
91582020 Flupentixol 20mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
91584020 Depixol 20mg/1ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
91592020 Zuclopenthixol decanoate 200mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
91596020 Clopixol 200mg/1ml solution for injection ampoules (Lundbeck Ltd) res41: Depot APDs Multilex drug
91981020 Pipotiazine 50mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
91985020 Pipotiazine 100mg/2ml solution for injection ampoules res41: Depot APDs Multilex drug
91987020 Piportil Depot 50mg/1ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
91989020 Piportil Depot 100mg/2ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
92200020 Fluphenazine decanoate 12.5mg/0.5ml solution for injection ampoules res41: Depot APDs Multilex drug
92202020 Fluphenazine decanoate 25mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
92204020 Fluphenazine decanoate 50mg/2ml solution for injection ampoules res41: Depot APDs Multilex drug
92206020 Modecate 12.5mg/0.5ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
92208020 Modecate 25mg/1ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
92210020 Modecate 50mg/2ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
92212020 Fluphenazine decanoate 50mg/0.5ml solution for injection ampoules res41: Depot APDs Multilex drug
92214020 Fluphenazine decanoate 100mg/1ml solution for injection ampoules res41: Depot APDs Multilex drug
92216020 Modecate Concentrate 50mg/0.5ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
92218020 Modecate Concentrate 100mg/1ml solution for injection ampoules (Sanofi) res41: Depot APDs Multilex drug
98278020 Olanzapine embonate 210mg powder and solvent for suspension for injection vials res41: Depot APDs Multilex drug
98329020 Olanzapine embonate 300mg powder and solvent for suspension for injection vials res41: Depot APDs Multilex drug
99841020 Paliperidone 50mg/0.5ml suspension for injection pre-filled syringes res41: Depot APDs Multilex drug
99843020 Paliperidone 75mg/0.75ml suspension for injection pre-filled syringes res41: Depot APDs Multilex drug
99845020 Paliperidone 100mg/1ml suspension for injection pre-filled syringes res41: Depot APDs Multilex drug
99847020 Paliperidone 150mg/1.5ml suspension for injection pre-filled syringes res41: Depot APDs Multilex drug
99849020 Xeplion 50mg/0.5ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) res41: Depot APDs Multilex drug
99851020 Xeplion 75mg/0.75ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) res41: Depot APDs Multilex drug
99853020 Xeplion 100mg/1ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) res41: Depot APDs Multilex drug
99855020 Xeplion 150mg/1.5ml suspension for injection pre-filled syringes (Janssen-Cilag Ltd) res41: Depot APDs Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH370/version/740/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH370/version/740/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH370', '740', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH370/version/740/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH370/version/740/export/codes/?format=json
CSV site_root/phenotypes/PH370/version/740/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH370', '740', api_client=client)

Version History

Version
ID
Name Owner Publish date
740 Depot APDs ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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