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Schizophrenia Spectrum

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Disease or Syndrome
ID
PH386
Version ID
772
Data Sources
Valid event data range
01/01/2001 - 31/12/2013
Sex
Female, Male
Agreement Date
2017-05-01
Coding system
Read codes v2
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

PURPOSE:

Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves.

METHODS:

During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice.

RESULTS:

We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for allcause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide.

CONCLUSIONS:

Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Premature Death Among Primary Care Patients With a History of Self-Harm. Annals of Family Medicine, 15(3), 2017.

Clinical Code List

Rows: 194
Code Description Entity type Category Coding System (Read)
1464.00 H/O: schizophrenia res41: Schizophrenia spectrum diagnostic Read
146H.00 H/O: psychosis res41: Schizophrenia spectrum diagnostic Read
1BH..00 Delusions res41: Schizophrenia spectrum diagnostic Read
1BH..11 Delusion res41: Schizophrenia spectrum diagnostic Read
1BH0.00 Delusion of persecution res41: Schizophrenia spectrum diagnostic Read
1BH1.00 Grandiose delusions res41: Schizophrenia spectrum diagnostic Read
1BH2.00 Ideas of reference res41: Schizophrenia spectrum diagnostic Read
1BH3.00 Paranoid ideation res41: Schizophrenia spectrum diagnostic Read
225E.00 O/E - paranoid delusions res41: Schizophrenia spectrum diagnostic Read
225F.00 O/E - delusion of persecution res41: Schizophrenia spectrum diagnostic Read
285..11 Psychotic condition, insight present res41: Schizophrenia spectrum diagnostic Read
286..11 Poor insight into psychotic condition res41: Schizophrenia spectrum diagnostic Read
665E.00 Injectable neuroleptic given res41: Schizophrenia spectrum diagnostic Read
665F.00 On injectable neuroleptic res41: Schizophrenia spectrum diagnostic Read
E1...00 Non-organic psychoses res41: Schizophrenia spectrum diagnostic Read
E10..00 Schizophrenic disorders res41: Schizophrenia spectrum diagnostic Read
E100.00 Simple schizophrenia res41: Schizophrenia spectrum diagnostic Read
E100.11 Schizophrenia simplex res41: Schizophrenia spectrum diagnostic Read
E100000 Unspecified schizophrenia res41: Schizophrenia spectrum diagnostic Read
E100100 Subchronic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E100200 Chronic schizophrenic res41: Schizophrenia spectrum diagnostic Read
E100300 Acute exacerbation of subchronic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E100400 Acute exacerbation of chronic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E100500 Schizophrenia in remission res41: Schizophrenia spectrum diagnostic Read
E100z00 Simple schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E101.00 Hebephrenic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E101000 Unspecified hebephrenic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E101400 Acute exacerbation of chronic hebephrenic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E101500 Hebephrenic schizophrenia in remission res41: Schizophrenia spectrum diagnostic Read
E101z00 Hebephrenic schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E102.00 Catatonic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E102000 Unspecified catatonic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E102100 Subchronic catatonic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E102500 Catatonic schizophrenia in remission res41: Schizophrenia spectrum diagnostic Read
E102z00 Catatonic schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E103.00 Paranoid schizophrenia res41: Schizophrenia spectrum diagnostic Read
E103000 Unspecified paranoid schizophrenia res41: Schizophrenia spectrum diagnostic Read
E103200 Chronic paranoid schizophrenia res41: Schizophrenia spectrum diagnostic Read
E103300 Acute exacerbation of subchronic paranoid schizophrenia res41: Schizophrenia spectrum diagnostic Read
E103400 Acute exacerbation of chronic paranoid schizophrenia res41: Schizophrenia spectrum diagnostic Read
E103500 Paranoid schizophrenia in remission res41: Schizophrenia spectrum diagnostic Read
E103z00 Paranoid schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E104.00 Acute schizophrenic episode res41: Schizophrenia spectrum diagnostic Read
E105.00 Latent schizophrenia res41: Schizophrenia spectrum diagnostic Read
E105000 Unspecified latent schizophrenia res41: Schizophrenia spectrum diagnostic Read
E105200 Chronic latent schizophrenia res41: Schizophrenia spectrum diagnostic Read
E105500 Latent schizophrenia in remission res41: Schizophrenia spectrum diagnostic Read
E105z00 Latent schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E106.00 Residual schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107.00 Schizo-affective schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107.11 Cyclic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107000 Unspecified schizo-affective schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107100 Subchronic schizo-affective schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107200 Chronic schizo-affective schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107300 Acute exacerbation subchronic schizo-affective schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107400 Acute exacerbation of chronic schizo-affective schizophrenia res41: Schizophrenia spectrum diagnostic Read
E107500 Schizo-affective schizophrenia in remission res41: Schizophrenia spectrum diagnostic Read
E107z00 Schizo-affective schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E10y.00 Other schizophrenia res41: Schizophrenia spectrum diagnostic Read
E10y.11 Cenesthopathic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E10y000 Atypical schizophrenia res41: Schizophrenia spectrum diagnostic Read
E10y100 Coenesthopathic schizophrenia res41: Schizophrenia spectrum diagnostic Read
E10yz00 Other schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E10z.00 Schizophrenia NOS res41: Schizophrenia spectrum diagnostic Read
E11z.00 Other and unspecified affective psychoses res41: Schizophrenia spectrum diagnostic Read
E11z000 Unspecified affective psychoses NOS res41: Schizophrenia spectrum diagnostic Read
E11zz00 Other affective psychosis NOS res41: Schizophrenia spectrum diagnostic Read
E12..00 Paranoid states res41: Schizophrenia spectrum diagnostic Read
E120.00 Simple paranoid state res41: Schizophrenia spectrum diagnostic Read
E121.00 Chronic paranoid psychosis res41: Schizophrenia spectrum diagnostic Read
E122.00 Paraphrenia res41: Schizophrenia spectrum diagnostic Read
E123.00 Shared paranoid disorder res41: Schizophrenia spectrum diagnostic Read
E12y.00 Other paranoid states res41: Schizophrenia spectrum diagnostic Read
E12y000 Paranoia querulans res41: Schizophrenia spectrum diagnostic Read
E12yz00 Other paranoid states NOS res41: Schizophrenia spectrum diagnostic Read
E12z.00 Paranoid psychosis NOS res41: Schizophrenia spectrum diagnostic Read
E13..00 Other nonorganic psychoses res41: Schizophrenia spectrum diagnostic Read
E13..11 Reactive psychoses res41: Schizophrenia spectrum diagnostic Read
E130.00 Reactive depressive psychosis res41: Schizophrenia spectrum diagnostic Read
E130.11 Psychotic reactive depression res41: Schizophrenia spectrum diagnostic Read
E131.00 Acute hysterical psychosis res41: Schizophrenia spectrum diagnostic Read
E133.00 Acute paranoid reaction res41: Schizophrenia spectrum diagnostic Read
E134.00 Psychogenic paranoid psychosis res41: Schizophrenia spectrum diagnostic Read
E13y.00 Other reactive psychoses res41: Schizophrenia spectrum diagnostic Read
E13y100 Brief reactive psychosis res41: Schizophrenia spectrum diagnostic Read
E13yz00 Other reactive psychoses NOS res41: Schizophrenia spectrum diagnostic Read
E13z.00 Nonorganic psychosis NOS res41: Schizophrenia spectrum diagnostic Read
E13z.11 Psychotic episode NOS res41: Schizophrenia spectrum diagnostic Read
E14..00 Psychoses with origin in childhood res41: Schizophrenia spectrum diagnostic Read
E141.00 Disintegrative psychosis res41: Schizophrenia spectrum diagnostic Read
E141.11 Heller's syndrome res41: Schizophrenia spectrum diagnostic Read
E141100 Residual disintegrative psychoses res41: Schizophrenia spectrum diagnostic Read
E1y..00 Other specified non-organic psychoses res41: Schizophrenia spectrum diagnostic Read
E1z..00 Non-organic psychosis NOS res41: Schizophrenia spectrum diagnostic Read
Eu02z12 [X] Presenile psychosis NOS res41: Schizophrenia spectrum diagnostic Read
Eu0z.12 [X]Symptomatic psychosis NOS res41: Schizophrenia spectrum diagnostic Read
Eu2..00 [X]Schizophrenia, schizotypal and delusional disorders res41: Schizophrenia spectrum diagnostic Read
Eu20.00 [X]Schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20000 [X]Paranoid schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20011 [X]Paraphrenic schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20100 [X]Hebephrenic schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20111 [X]Disorganised schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20200 [X]Catatonic schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20211 [X]Catatonic stupor res41: Schizophrenia spectrum diagnostic Read
Eu20212 [X]Schizophrenic catalepsy res41: Schizophrenia spectrum diagnostic Read
Eu20213 [X]Schizophrenic catatonia res41: Schizophrenia spectrum diagnostic Read
Eu20214 [X]Schizophrenic flexibilatis cerea res41: Schizophrenia spectrum diagnostic Read
Eu20300 [X]Undifferentiated schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20311 [X]Atypical schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20500 [X]Residual schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20511 [X]Chronic undifferentiated schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20600 [X]Simple schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20y00 [X]Other schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu20y12 [X]Schizophreniform disord NOS res41: Schizophrenia spectrum diagnostic Read
Eu20y13 [X]Schizophrenifrm psychos NOS res41: Schizophrenia spectrum diagnostic Read
Eu20z00 [X]Schizophrenia, unspecified res41: Schizophrenia spectrum diagnostic Read
Eu21.00 [X]Schizotypal disorder res41: Schizophrenia spectrum diagnostic Read
Eu21.11 [X]Latent schizophrenic reaction res41: Schizophrenia spectrum diagnostic Read
Eu21.12 [X]Borderline schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu21.13 [X]Latent schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu21.14 [X]Prepsychotic schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu21.15 [X]Prodromal schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu21.16 [X]Pseudoneurotic schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu22.00 [X]Persistent delusional disorders res41: Schizophrenia spectrum diagnostic Read
Eu22000 [X]Delusional disorder res41: Schizophrenia spectrum diagnostic Read
Eu22011 [X]Paranoid psychosis res41: Schizophrenia spectrum diagnostic Read
Eu22012 [X]Paranoid state res41: Schizophrenia spectrum diagnostic Read
Eu22013 [X]Paraphrenia - late res41: Schizophrenia spectrum diagnostic Read
Eu22014 [X]Sensitiver Beziehungswahn res41: Schizophrenia spectrum diagnostic Read
Eu22015 [X]Paranoia res41: Schizophrenia spectrum diagnostic Read
Eu22100 [X]Delusional misidentification syndrome res41: Schizophrenia spectrum diagnostic Read
Eu22111 [X]Capgras syndrome res41: Schizophrenia spectrum diagnostic Read
Eu22y00 [X]Other persistent delusional disorders res41: Schizophrenia spectrum diagnostic Read
Eu22y11 [X]Delusional dysmorphophobia res41: Schizophrenia spectrum diagnostic Read
Eu22y12 [X]Involutional paranoid state res41: Schizophrenia spectrum diagnostic Read
Eu22y13 [X]Paranoia querulans res41: Schizophrenia spectrum diagnostic Read
Eu22z00 [X]Persistent delusional disorder, unspecified res41: Schizophrenia spectrum diagnostic Read
Eu23.00 [X]Acute and transient psychotic disorders res41: Schizophrenia spectrum diagnostic Read
Eu23000 [X]Acute polymorphic psychot disord without symp of schizoph res41: Schizophrenia spectrum diagnostic Read
Eu23012 [X]Cycloid psychosis res41: Schizophrenia spectrum diagnostic Read
Eu23100 [X]Acute polymorphic psychot disord with symp of schizophren res41: Schizophrenia spectrum diagnostic Read
Eu23112 [X]Cycloid psychosis with symptoms of schizophrenia res41: Schizophrenia spectrum diagnostic Read
Eu23200 [X]Acute schizophrenia-like psychotic disorder res41: Schizophrenia spectrum diagnostic Read
Eu23211 [X]Brief schizophreniform disorder res41: Schizophrenia spectrum diagnostic Read
Eu23212 [X]Brief schizophrenifrm psych res41: Schizophrenia spectrum diagnostic Read
Eu23214 [X]Schizophrenic reaction res41: Schizophrenia spectrum diagnostic Read
Eu23300 [X]Other acute predominantly delusional psychotic disorders res41: Schizophrenia spectrum diagnostic Read
Eu23312 [X]Psychogenic paranoid psychosis res41: Schizophrenia spectrum diagnostic Read
Eu23y00 [X]Other acute and transient psychotic disorders res41: Schizophrenia spectrum diagnostic Read
Eu23z00 [X]Acute and transient psychotic disorder, unspecified res41: Schizophrenia spectrum diagnostic Read
Eu23z11 [X]Brief reactive psychosis NOS res41: Schizophrenia spectrum diagnostic Read
Eu23z12 [X]Reactive psychosis res41: Schizophrenia spectrum diagnostic Read
Eu25.00 [X]Schizoaffective disorders res41: Schizophrenia spectrum diagnostic Read
Eu25000 [X]Schizoaffective disorder, manic type res41: Schizophrenia spectrum diagnostic Read
Eu25011 [X]Schizoaffective psychosis, manic type res41: Schizophrenia spectrum diagnostic Read
Eu25012 [X]Schizophreniform psychosis, manic type res41: Schizophrenia spectrum diagnostic Read
Eu25100 [X]Schizoaffective disorder, depressive type res41: Schizophrenia spectrum diagnostic Read
Eu25111 [X]Schizoaffective psychosis, depressive type res41: Schizophrenia spectrum diagnostic Read
Eu25112 [X]Schizophreniform psychosis, depressive type res41: Schizophrenia spectrum diagnostic Read
Eu25200 [X]Schizoaffective disorder, mixed type res41: Schizophrenia spectrum diagnostic Read
Eu25212 [X]Mixed schizophrenic and affective psychosis res41: Schizophrenia spectrum diagnostic Read
Eu25y00 [X]Other schizoaffective disorders res41: Schizophrenia spectrum diagnostic Read
Eu25z00 [X]Schizoaffective disorder, unspecified res41: Schizophrenia spectrum diagnostic Read
Eu25z11 [X]Schizoaffective psychosis NOS res41: Schizophrenia spectrum diagnostic Read
Eu2y.00 [X]Other nonorganic psychotic disorders res41: Schizophrenia spectrum diagnostic Read
Eu2y.11 [X]Chronic hallucinatory psychosis res41: Schizophrenia spectrum diagnostic Read
Eu2z.00 [X]Unspecified nonorganic psychosis res41: Schizophrenia spectrum diagnostic Read
Eu2z.11 [X]Psychosis NOS res41: Schizophrenia spectrum diagnostic Read
Eu32300 [X]Severe depressive episode with psychotic symptoms res41: Schizophrenia spectrum diagnostic Read
Eu32311 [X]Single episode of major depression and psychotic symptoms res41: Schizophrenia spectrum diagnostic Read
Eu32312 [X]Single episode of psychogenic depressive psychosis res41: Schizophrenia spectrum diagnostic Read
Eu32313 [X]Single episode of psychotic depression res41: Schizophrenia spectrum diagnostic Read
Eu32314 [X]Single episode of reactive depressive psychosis res41: Schizophrenia spectrum diagnostic Read
Eu32900 [X]Single major depr ep, severe with psych, psych in remiss res41: Schizophrenia spectrum diagnostic Read
Eu32A00 [X]Recurr major depr ep, severe with psych, psych in remiss res41: Schizophrenia spectrum diagnostic Read
Eu33300 [X]Recurrent depress disorder cur epi severe with psyc symp res41: Schizophrenia spectrum diagnostic Read
Eu33311 [X]Endogenous depression with psychotic symptoms res41: Schizophrenia spectrum diagnostic Read
Eu33313 [X]Recurr severe episodes/major depression+psychotic symptom res41: Schizophrenia spectrum diagnostic Read
Eu33314 [X]Recurr severe episodes/psychogenic depressive psychosis res41: Schizophrenia spectrum diagnostic Read
Eu33315 [X]Recurrent severe episodes of psychotic depression res41: Schizophrenia spectrum diagnostic Read
Eu33316 [X]Recurrent severe episodes/reactive depressive psychosis res41: Schizophrenia spectrum diagnostic Read
Eu44.14 [X]Hysterical psychosis res41: Schizophrenia spectrum diagnostic Read
Eu84312 [X]Disintegrative psychosis res41: Schizophrenia spectrum diagnostic Read
Eu84314 [X]Symbiotic psychosis res41: Schizophrenia spectrum diagnostic Read
R001.00 [D]Hallucinations res41: Schizophrenia spectrum diagnostic Read
R001000 [D]Hallucinations, auditory res41: Schizophrenia spectrum diagnostic Read
R001100 [D]Hallucinations, gustatory res41: Schizophrenia spectrum diagnostic Read
R001200 [D]Hallucinations, olfactory res41: Schizophrenia spectrum diagnostic Read
R001300 [D]Hallucinations, tactile res41: Schizophrenia spectrum diagnostic Read
R001400 [D]Visual hallucinations res41: Schizophrenia spectrum diagnostic Read
R001z00 [D]Hallucinations NOS res41: Schizophrenia spectrum diagnostic Read
Ryu5300 [X]Other hallucinations res41: Schizophrenia spectrum diagnostic Read
ZS7C611 Schizophrenic language res41: Schizophrenia spectrum diagnostic Read
ZV11000 [V]Personal history of schizophrenia res41: Schizophrenia spectrum diagnostic Read

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH386/version/772/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH386/version/772/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH386', '772', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH386/version/772/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH386/version/772/export/codes/?format=json
CSV site_root/phenotypes/PH386/version/772/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH386', '772', api_client=client)

Version History

Version
ID
Name Owner Publish date
772 Schizophrenia Spectrum ieuan.scanlon 2021-10-06 currently shown

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