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Screen Cervical

Matthew Carr, Evan Kontopantelis, Tim Doran, Christine Campbell, Lorraine Lipscombe, Emma Crosbie, Anothony Howell, Iain E Buchan, Andrew G Renehan

Type
Biomarker
ID
PH389
Version ID
778
Data Sources
Valid event data range
1999 - 2011
Sex
Female
Agreement Date
2015-01-01
Coding system
Read codes v2 OXMIS codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Aims/hypothesis:

Studies from healthcare databases suggest that patients with type 2 diabetes (T2D) under-utilize cancer screening opportunities, but recording bias may be a problem. We evaluated the relative effect of T2D on screening utilization trends among long-established UK national programmes in breast and cervical cancers; and tested the impact of introducing a primary care financial incentive scheme (QOF) in 2004, known to improve data recording for diabetes-related care.

Materials and methods:

Using the Clinical Practice Research Datalink, we identified women with prevalent T2DM (N = 174,256), separately by year for 1999 to 2011, and eligible for screening events for breast (aged 50-70 years) and cervical (aged 35-49 and 50-64 years) cancers. We described secular trends and compared these with the non-diabetes population, and accounted for co-morbidities using matched conditional logistic regression models. We performed interrupted time-series (ITS) analyses to assess the impact of the QOF introduction.

Results:

Compared with the non-diabetes population, relative uptake rates for breast and cervical screening were generally similar in patients with T2D pre-2004, becoming greater for years post-2004. These patterns were unaffected by adjustment for GP practice, and were not accounted for by T2D associated co-morbidities. ITS analysis showed increased activities in all three screening groups for 2007, but these broadly returned to pre-2004 trends by 2011, paralleling similar patterns in recording for other care provision indicators.

Conclusions/interpretation:

In this population, we found no evidence that women with T2D under-utilize breast and cervical cancer screening opportunities. A financial incentive scheme was associated with intermediate-term improvements in screening utilization, but this is likely to reflect improved recording of care events.

Publications

  • Magthew Carr, Even Kontopantelis, Tim Doran, Christian Campbell, Lorraine Lipscombe, Emma Crosbie, Anthony Howell, Iain E Buchan, Andrew G Renehan, Breast and Cervical Cancer Screening Utilization, and recording bias, in women with type 2 diabetes (UK). 2015.

Clinical Code List

Rows: 79
Code Description Entity type Coding System (OXMIS Read) Category
4149.00 Cervical cytology sample sent to laboratory res22: screen_cervical Read test
4JRL.00 Cervical cytology screening test res22: screen_cervical Read test
4K2..00 Cervical smear result res22: screen_cervical Read test
4K2..11 Dyskaryosis on cervical smear res22: screen_cervical Read test
4K2..12 Dysplasia (dysk.)on cerv.smear res22: screen_cervical Read test
4K21.00 Cervical smear:inadequate spec res22: screen_cervical Read test
4K22.00 Cervical smear: negative res22: screen_cervical Read test
4K22.11 Smear NAD: no endocervic cells res22: screen_cervical Read test
4K23.00 Cerv.smear: mild dyskaryosis res22: screen_cervical Read test
4K24.00 Cerv.smear: severe dyskaryosis res22: screen_cervical Read test
4K25.00 Cerv.smear:severe dysk.?inv.ca res22: screen_cervical Read test
4K26.00 Cervical smear: ? gland neopl. res22: screen_cervical Read test
4K27.00 Cervical smear:atrophic change res22: screen_cervical Read test
4K27.11 Atrophic change on cerv.smear res22: screen_cervical Read test
4K28.00 Cerv.smear: mod.dyskaryosis res22: screen_cervical Read test
4K29.00 Cerv.smear: borderline changes res22: screen_cervical Read test
4K2A.00 Cervical smear endocervical cells present res22: screen_cervical Read test
4K2B.00 Cervical smear endocervical cells absent res22: screen_cervical Read test
4K2C.00 Smear NAD - no endocervical cells res22: screen_cervical Read test
4K2D.00 Cervical smear transformation zone cells present res22: screen_cervical Read test
4K2E.00 Cervical smear transformation zone cells absent res22: screen_cervical Read test
4K2F.00 res22: screen_cervical Read test
4K2Z.00 Cervical smear result NOS res22: screen_cervical Read test
4K2Z.11 Nuclear abnormality on smear res22: screen_cervical Read test
4K3..00 Cervical smear - inflam.change res22: screen_cervical Read test
4K31.00 Cervical smear-no inflammation res22: screen_cervical Read test
4K32.00 Cervical smear-severe inflamm. res22: screen_cervical Read test
4K33.00 Cervical smear - trichomonas res22: screen_cervical Read test
4K34.00 Cervical smear - candida res22: screen_cervical Read test
4K35.00 Cerv.smear - viral infl.unsp. res22: screen_cervical Read test
4K35.11 Viral changes on cerv. smear res22: screen_cervical Read test
4K36.00 Cervical smear - wart virus res22: screen_cervical Read test
4K36.12 HPV changes: cervical smear res22: screen_cervical Read test
4K3A.00 Cervical smear: koilocytosis res22: screen_cervical Read test
4K3B.00 Cervical smear - mild inflammation res22: screen_cervical Read test
4K3C.00 Cervical smear - moderate inflammation res22: screen_cervical Read test
4K3Z.00 Cervical smear - inflam. NOS res22: screen_cervical Read test
4K4..00 Cervical smear - action needed res22: screen_cervical Read test
4K48.00 Cx. smear: colposcopy needed res22: screen_cervical Read test
4K49.00 Cx. smear:cervical biopsy need res22: screen_cervical Read test
4K4Z.00 Cervical smear action NOS res22: screen_cervical Read test
4K55.00 Cervical cytology test res22: screen_cervical Read test
4KA..00 Vaginal vault smear result res22: screen_cervical Read test
4KA1.00 Vaginal vault smear negative res22: screen_cervical Read test
4KA4.00 Vaginal vault smear abnormal res22: screen_cervical Read test
685..00 Cervical neoplasia screening res22: screen_cervical Read test
685..11 Cervical cytology screen res22: screen_cervical Read test
685..12 Cervical smear screen res22: screen_cervical Read test
6859.00 Ca cervix - screen done res22: screen_cervical Read test
6859.11 Cervical cytology examination res22: screen_cervical Read test
685A.00 Ca cervix screen-no result yet res22: screen_cervical Read test
685B.00 Ca cervix screen normal res22: screen_cervical Read test
685C.00 Ca cervix screen abnormal res22: screen_cervical Read test
685D.00 Ca cervix screen + fee claim res22: screen_cervical Read test
685E.00 Cervical smear status unknown res22: screen_cervical Read test
685R.00 Liquid based cervical cytology screening res22: screen_cervical Read test
685Z.00 Ca cervix screen NOS res22: screen_cervical Read test
7E2A000 Exam female genital tract under anaesth & Papanicolau smear res22: screen_cervical Read test
7E2A200 Papanicolau smear NEC res22: screen_cervical Read test
7E2A211 Cervical smear NEC res22: screen_cervical Read test
7E2A300 Vaginal vault smear res22: screen_cervical Read test
981..00 FP74 - cervical cytology claim res22: screen_cervical Read test
981..11 Cervical smear - fee claim res22: screen_cervical Read test
9O81.00 Cervical smear - 1st call res22: screen_cervical Read test
9O8A.00 Abnormal smear - 1st recall res22: screen_cervical Read test
9O8R.00 Smear normal - pt. notified res22: screen_cervical Read test
9O8T.00 Cervical smear slide lost in transit res22: screen_cervical Read test
9O8U.00 Cervical smear slide broken in transit res22: screen_cervical Read test
9O8V.00 Place cervical smear taken res22: screen_cervical Read test
R150.00 [D]Nonspecific abnormal Papanicolaou cervical smear res22: screen_cervical Read test
R150.11 [D]Cervical smear - nonspecific abnormality res22: screen_cervical Read test
R150.12 [D]Papanicolaou smear - nonspecific abnormality res22: screen_cervical Read test
R150000 [D]Dyskaryotic cervical smear res22: screen_cervical Read test
R150100 [D] Koilocytosis - cervical smear res22: screen_cervical Read test
R150z00 [D]Nonspecific abnormal Papanicolaou cervical smear NOS res22: screen_cervical Read test
R151.00 [D]Nonspecific abnormal Papanicolaou smear of other origin res22: screen_cervical Read test
ZV76200 [V]Screening for malignant neoplasm of cervix res22: screen_cervical Read test
ZV76211 [V]Routine Papanicolaou smear res22: screen_cervical Read test
ZV76212 [V]Routine cervical smear res22: screen_cervical Read test
Rows: 12
Code Description Entity type Coding System (OXMIS Read) Category
9O89.00 SMEAR ABNORMAL - PATIENT TOLD res22: screen_cervical OXMIS test
9O89.11 SMEAR ABNORMAL - PT. NOTIFIED res22: screen_cervical OXMIS test
L3230T CERVICAL SMEAR TAKEN res22: screen_cervical OXMIS test
L9160 PAP SMEAR EXAMINATION res22: screen_cervical OXMIS test
L9160NG PAP SMEAR NEGATIVE res22: screen_cervical OXMIS test
L9161AC CERVICAL SMEAR ABNORMAL res22: screen_cervical OXMIS test
L9162 CERVICAL SMEAR res22: screen_cervical OXMIS test
L9162BA SMEAR INFLAMED res22: screen_cervical OXMIS test
L9162N NEGATIVE - CERVICAL SMEAR res22: screen_cervical OXMIS test
L9162PJ CARCINOMA IN SITU - CERVICAL SMEAR res22: screen_cervical OXMIS test
L9162PP CERVICAL SMEAR CIN I res22: screen_cervical OXMIS test
L9162PQ CERVICAL SMEAR CIN II res22: screen_cervical OXMIS test

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH389/version/778/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH389/version/778/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH389', '778', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH389/version/778/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH389/version/778/export/codes/?format=json
CSV site_root/phenotypes/PH389/version/778/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH389', '778', api_client=client)

Version History

Version
ID
Name Owner Publish date
778 Screen Cervical ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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