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selective serotonin reuptake inhibitor (SSRI) adds

Matthew J Carr, Darren M Ashscroft, Evangelos Kontopantelis, David While, Yvonne Awenant, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Drug
ID
PH394
Version ID
788
Data Sources
Valid event data range
01/01/2001 - 31/12/2012
Sex
Female, Male
Agreement Date
2016-03-08
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Background:

Little is known about the clinical management of patients in primary care following self-harm.

Methods:

A descriptive cohort study using data from 684 UK general practices that contributed to the Clinical Practice Research Datalink (CPRD) during 2001-2013. We identified 49,970 patients with a self-harm episode, 41,500 of whom had one complete year of follow-up.

Results:

Among those with complete follow-up, 26,065 (62.8%, 62.3-63.3) were prescribed psychotropic medication and 6318 (15.2%, 14.9-15.6) were referred to mental health services; 4105 (9.9%, CI 9.6-10.2) were medicated without an antecedent psychiatric diagnosis or referral, and 4,506 (10.9%, CI 10.6-11.2) had a diagnosis but were not subsequently medicated or referred. Patients registered at practices in the most deprived localities were 27.1% (CI 21.5-32.2) less likely to be referred than those in the least deprived. Despite a specifically flagged NICE 'Do not do' recommendation in 2011 against prescribing tricyclic antidepressants following self-harm because of their potentially lethal toxicity in overdose, 8.8% (CI 7.8-9.8) of individuals were issued a prescription in the subsequent year. The percentage prescribed Citalopram, an SSRI antidepressant with higher toxicity in overdose, fell sharply during 2012/2013 in the aftermath of a Medicines and Healthcare products Regulatory Agency (MHRA) safety alert issued in 2011.

Conclusions:

A relatively small percentage of these vulnerable patients are referred to mental health services, and reduced likelihood of referral in more deprived localities reflects a marked health inequality. National clinical guidelines have not yet been effective in reducing rates of tricyclic antidepressant prescribing for this high-risk group.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenant, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Clinical management following self-harm in a UK-wide primary care cohort. Journal of Affective Disorders, 197(2016) 182-188, 2016.

Clinical Code List

Rows: 120
Code Description Entity type Coding System (Multilex) Category
20738020 Sertraline 100mg/5ml oral suspension res36: SSRI ADDs Multilex drug
33816020 Sertraline 25mg/5ml oral suspension res36: SSRI ADDs Multilex drug
3837020 Prozac 20mg capsules (Lexon (UK) Ltd) res36: SSRI ADDs Multilex drug
38526020 Citalopram 20mg tablets (DE Pharmaceuticals) res36: SSRI ADDs Multilex drug
3985020 Citalopram 20mg tablets (Alliance Healthcare (Distribution) Ltd) res36: SSRI ADDs Multilex drug
3997020 Citalopram 20mg tablets (Bristol Laboratories Ltd) res36: SSRI ADDs Multilex drug
4003020 Citalopram 10mg tablets (Kent Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
4004020 Citalopram 10mg tablets (Alliance Healthcare (Distribution) Ltd) res36: SSRI ADDs Multilex drug
4007020 Citalopram 10mg tablets (Arrow Generics Ltd) res36: SSRI ADDs Multilex drug
4011020 Citalopram 10mg tablets (Bristol Laboratories Ltd) res36: SSRI ADDs Multilex drug
49680020 Felicium 20mg capsules (Opus Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
53823020 Escitalopram 20mg tablets res36: SSRI ADDs Multilex drug
55602020 Cipralex 20mg tablets (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
60735020 Fluvoxamine 100mg tablets (IVAX Pharmaceuticals UK Ltd) res36: SSRI ADDs Multilex drug
61084020 Fluoxetine 20mg capsules (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
61167020 Fluoxetine 20mg capsules (IVAX Pharmaceuticals UK Ltd) res36: SSRI ADDs Multilex drug
61319020 Fluoxetine 20mg capsules (Teva UK Ltd) res36: SSRI ADDs Multilex drug
61387020 Fluoxetine 20mg capsules (Sandoz Ltd) res36: SSRI ADDs Multilex drug
61409020 Fluoxetine 20mg capsules (Generics (UK) Ltd) res36: SSRI ADDs Multilex drug
61420020 Fluoxetine 20mg capsules (Niche Generics Ltd) res36: SSRI ADDs Multilex drug
61439020 Fluoxetine 20mg capsules (Wockhardt UK Ltd) res36: SSRI ADDs Multilex drug
61452020 Fluoxetine 20mg capsules (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
61455020 Fluoxetine 20mg capsules (Genus Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
61616020 Fluoxetine 20mg capsules (Zentiva) res36: SSRI ADDs Multilex drug
62069020 Fluvoxamine 50mg tablets res36: SSRI ADDs Multilex drug
62070020 Fluvoxamine 100mg tablets res36: SSRI ADDs Multilex drug
62073020 Faverin 50mg tablets (Abbott Healthcare Products Ltd) res36: SSRI ADDs Multilex drug
62074020 Faverin 100mg tablets (Abbott Healthcare Products Ltd) res36: SSRI ADDs Multilex drug
62693020 Fluvoxamine 100mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
62975020 Fluoxetine 20mg capsules (Fannin UK Ltd) res36: SSRI ADDs Multilex drug
63016020 Fluoxetine 20mg capsules (Ranbaxy (UK) Ltd) res36: SSRI ADDs Multilex drug
63703020 Paroxetine 20mg tablets (IVAX Pharmaceuticals UK Ltd) res36: SSRI ADDs Multilex drug
64692020 Fluoxetine 20mg/5ml oral solution (Teva UK Ltd) res36: SSRI ADDs Multilex drug
64717020 Fluoxetine 20mg/5ml oral solution (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
65125020 Citalopram 10mg tablets (Sandoz Ltd) res36: SSRI ADDs Multilex drug
65128020 Citalopram 20mg tablets (Sandoz Ltd) res36: SSRI ADDs Multilex drug
65131020 Citalopram 40mg tablets (Sandoz Ltd) res36: SSRI ADDs Multilex drug
65254020 Citalopram 10mg Tablet (Neo Laboratories Ltd) res36: SSRI ADDs Multilex drug
65257020 Citalopram 20mg Tablet (Neo Laboratories Ltd) res36: SSRI ADDs Multilex drug
65262020 Citalopram 40mg Tablet (Neo Laboratories Ltd) res36: SSRI ADDs Multilex drug
65376020 Citalopram 10mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
65381020 Citalopram 20mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
65386020 Citalopram 40mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
65464020 Fluoxetine 60mg capsules (Generics (UK) Ltd) res36: SSRI ADDs Multilex drug
65578020 Paroxetine 20mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
66129020 Fluoxetine 20mg/5ml oral solution (IVAX Pharmaceuticals UK Ltd) res36: SSRI ADDs Multilex drug
66149020 Citalopram 10mg tablets (Zentiva) res36: SSRI ADDs Multilex drug
66152020 Citalopram 20mg tablets (Zentiva) res36: SSRI ADDs Multilex drug
66160020 Citalopram 40mg tablets (Zentiva) res36: SSRI ADDs Multilex drug
66244020 Fluvoxamine 100mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
66273020 Fluoxetine 20mg capsules (Tillomed Laboratories Ltd) res36: SSRI ADDs Multilex drug
66399020 Paroxetine 20mg tablets (Generics (UK) Ltd) res36: SSRI ADDs Multilex drug
66451020 Citalopram 10mg tablets (Generics (UK) Ltd) res36: SSRI ADDs Multilex drug
66454020 Citalopram 20mg tablets (Generics (UK) Ltd) res36: SSRI ADDs Multilex drug
66459020 Citalopram 40mg tablets (Generics (UK) Ltd) res36: SSRI ADDs Multilex drug
66464020 Paroxetine 20mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
66680020 Citalopram 10mg tablets (Niche Generics Ltd) res36: SSRI ADDs Multilex drug
66685020 Citalopram 20mg tablets (Niche Generics Ltd) res36: SSRI ADDs Multilex drug
66688020 Citalopram 40mg tablets (Niche Generics Ltd) res36: SSRI ADDs Multilex drug
67575020 Paroxetine 30mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
67650020 Paroxetine 30mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
67890020 Citalopram 10mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
67893020 Citalopram 20mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
67898020 Citalopram 40mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
68042020 Citalopram 10mg tablets (Teva UK Ltd) res36: SSRI ADDs Multilex drug
68045020 Citalopram 20mg tablets (Teva UK Ltd) res36: SSRI ADDs Multilex drug
68049020 Citalopram 40mg tablets (Teva UK Ltd) res36: SSRI ADDs Multilex drug
69506020 Prozac 20mg capsules (Eli Lilly and Company Ltd) res36: SSRI ADDs Multilex drug
69507020 Prozac 20mg/5ml liquid (Eli Lilly and Company Ltd) res36: SSRI ADDs Multilex drug
69508020 Prozac 60mg capsules (Eli Lilly and Company Ltd) res36: SSRI ADDs Multilex drug
69654020 Fluoxetine 20mg capsules res36: SSRI ADDs Multilex drug
69655020 Fluoxetine 20mg/5ml oral solution res36: SSRI ADDs Multilex drug
69656020 Fluoxetine 60mg capsules res36: SSRI ADDs Multilex drug
69754020 Paroxetine 20mg tablets (Genus Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
71214020 Citalopram 10mg tablets (PLIVA Pharma Ltd) res36: SSRI ADDs Multilex drug
71225020 Citalopram 10mg tablets (IVAX Pharmaceuticals UK Ltd) res36: SSRI ADDs Multilex drug
71373020 Citalopram 10mg tablets (Almus Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
71376020 Citalopram 20mg tablets (Almus Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
71725020 Sertraline 50mg tablets (A A H Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
72034020 Sertraline 50mg tablets (Actavis UK Ltd) res36: SSRI ADDs Multilex drug
72095020 Sertraline 100mg tablets (Teva UK Ltd) res36: SSRI ADDs Multilex drug
72932020 Paroxetine 20mg tablets res36: SSRI ADDs Multilex drug
72933020 Paroxetine 30mg tablets res36: SSRI ADDs Multilex drug
72934020 Paroxetine 10mg/5ml oral suspension sugar free res36: SSRI ADDs Multilex drug
72937020 Seroxat 20mg tablets (GlaxoSmithKline UK Ltd) res36: SSRI ADDs Multilex drug
72938020 Seroxat 30mg tablets (GlaxoSmithKline UK Ltd) res36: SSRI ADDs Multilex drug
72939020 Seroxat 20mg/10ml liquid (GlaxoSmithKline UK Ltd) res36: SSRI ADDs Multilex drug
74046020 Lustral 50mg tablets (Pfizer Ltd) res36: SSRI ADDs Multilex drug
74047020 Lustral 100mg tablets (Pfizer Ltd) res36: SSRI ADDs Multilex drug
74050020 Sertraline 50mg tablets res36: SSRI ADDs Multilex drug
74051020 Sertraline 100mg tablets res36: SSRI ADDs Multilex drug
74425020 Fluoxetine 20mg Capsule (Milpharm Ltd) res36: SSRI ADDs Multilex drug
75620020 Sertraline 50mg tablets (Almus Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
77306020 Citalopram 40mg/ml oral drops sugar free res36: SSRI ADDs Multilex drug
77312020 Cipramil 40mg/ml drops (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
78768020 Escitalopram 10mg tablets res36: SSRI ADDs Multilex drug
79420020 Cipramil 20mg tablets (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
79421020 Cipramil 10mg tablets (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
79422020 Cipramil 40mg tablets (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
79462020 Citalopram 20mg tablets res36: SSRI ADDs Multilex drug
79463020 Citalopram 10mg tablets res36: SSRI ADDs Multilex drug
79464020 Citalopram 40mg tablets res36: SSRI ADDs Multilex drug
80679020 Oxactin 20mg capsules (Discovery Pharmaceuticals Ltd) res36: SSRI ADDs Multilex drug
80777020 Prozit 20mg/5ml oral solution (Pinewood Healthcare) res36: SSRI ADDs Multilex drug
82055020 Ranflutin 20mg capsules (Ranbaxy (UK) Ltd) res36: SSRI ADDs Multilex drug
86222020 Cipralex 10mg tablets (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
87524020 Escitalopram 5mg tablets res36: SSRI ADDs Multilex drug
87526020 Cipralex 5mg tablets (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
88346020 Paxoran 10mg Tablet (Ranbaxy (UK) Ltd) res36: SSRI ADDs Multilex drug
88348020 Paxoran 20mg Tablet (Ranbaxy (UK) Ltd) res36: SSRI ADDs Multilex drug
90497020 Sertraline 50mg/5ml oral suspension res36: SSRI ADDs Multilex drug
90871020 Escitalopram 10mg/ml oral drops sugar free res36: SSRI ADDs Multilex drug
90873020 Cipralex 10mg/ml oral drops (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
92043020 Paroxetine 10mg tablets res36: SSRI ADDs Multilex drug
93187020 Seroxat 10mg tablets (GlaxoSmithKline UK Ltd) res36: SSRI ADDs Multilex drug
93918020 Prozep 20mg/5ml oral solution (Chemidex Pharma Ltd) res36: SSRI ADDs Multilex drug
93984020 Fluoxetine 20mg/5ml oral solution sugar free res36: SSRI ADDs Multilex drug
97169020 Escitalopram 20mg/ml oral drops sugar free res36: SSRI ADDs Multilex drug
97171020 Cipralex 20mg/ml oral drops (Lundbeck Ltd) res36: SSRI ADDs Multilex drug
98001020 Fluoxetine 10mg tablets res36: SSRI ADDs Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH394/version/788/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH394/version/788/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH394', '788', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH394/version/788/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH394/version/788/export/codes/?format=json
CSV site_root/phenotypes/PH394/version/788/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH394', '788', api_client=client)

Version History

Version
ID
Name Owner Publish date
788 selective serotonin reuptake inhibitor (SSRI) adds ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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