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selective serotonin reuptake inhibitor (SSRI) Adds

Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb

Type
Drug
ID
PH395
Version ID
790
Data Sources
Valid event data range
01/01/2001 - 31/12/2013
Sex
Female, Male
Agreement Date
2017-05-01
Coding system
Multilex codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

PURPOSE:

Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves.

METHODS:

During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice.

RESULTS:

We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for allcause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide.

CONCLUSIONS:

Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches.

Publications

  • Matthew J Carr, Darren M Ashcroft, Evangelos Kontopantelis, David While, Yvonne Awenat, Jayne Cooper, Carolyn Chew-Graham, Nav Kapur, Roger T Webb, Premature Death Among Primary Care Patients With a History of Self-Harm. Annals of Family Medicine, 15(3), 2017.

Clinical Code List

Rows: 120
Code Description Entity type Coding System (Multilex) Category
20738020 Sertraline 100mg/5ml oral suspension res41: SSRI ADDs Multilex drug
33816020 Sertraline 25mg/5ml oral suspension res41: SSRI ADDs Multilex drug
3837020 Prozac 20mg capsules (Lexon (UK) Ltd) res41: SSRI ADDs Multilex drug
38526020 Citalopram 20mg tablets (DE Pharmaceuticals) res41: SSRI ADDs Multilex drug
3985020 Citalopram 20mg tablets (Alliance Healthcare (Distribution) Ltd) res41: SSRI ADDs Multilex drug
3997020 Citalopram 20mg tablets (Bristol Laboratories Ltd) res41: SSRI ADDs Multilex drug
4003020 Citalopram 10mg tablets (Kent Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
4004020 Citalopram 10mg tablets (Alliance Healthcare (Distribution) Ltd) res41: SSRI ADDs Multilex drug
4007020 Citalopram 10mg tablets (Arrow Generics Ltd) res41: SSRI ADDs Multilex drug
4011020 Citalopram 10mg tablets (Bristol Laboratories Ltd) res41: SSRI ADDs Multilex drug
49680020 Felicium 20mg capsules (Opus Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
53823020 Escitalopram 20mg tablets res41: SSRI ADDs Multilex drug
55602020 Cipralex 20mg tablets (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
60735020 Fluvoxamine 100mg tablets (IVAX Pharmaceuticals UK Ltd) res41: SSRI ADDs Multilex drug
61084020 Fluoxetine 20mg capsules (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
61167020 Fluoxetine 20mg capsules (IVAX Pharmaceuticals UK Ltd) res41: SSRI ADDs Multilex drug
61319020 Fluoxetine 20mg capsules (Teva UK Ltd) res41: SSRI ADDs Multilex drug
61387020 Fluoxetine 20mg capsules (Sandoz Ltd) res41: SSRI ADDs Multilex drug
61409020 Fluoxetine 20mg capsules (Generics (UK) Ltd) res41: SSRI ADDs Multilex drug
61420020 Fluoxetine 20mg capsules (Niche Generics Ltd) res41: SSRI ADDs Multilex drug
61439020 Fluoxetine 20mg capsules (Wockhardt UK Ltd) res41: SSRI ADDs Multilex drug
61452020 Fluoxetine 20mg capsules (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
61455020 Fluoxetine 20mg capsules (Genus Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
61616020 Fluoxetine 20mg capsules (Zentiva) res41: SSRI ADDs Multilex drug
62069020 Fluvoxamine 50mg tablets res41: SSRI ADDs Multilex drug
62070020 Fluvoxamine 100mg tablets res41: SSRI ADDs Multilex drug
62073020 Faverin 50mg tablets (Abbott Healthcare Products Ltd) res41: SSRI ADDs Multilex drug
62074020 Faverin 100mg tablets (Abbott Healthcare Products Ltd) res41: SSRI ADDs Multilex drug
62693020 Fluvoxamine 100mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
62975020 Fluoxetine 20mg capsules (Fannin UK Ltd) res41: SSRI ADDs Multilex drug
63016020 Fluoxetine 20mg capsules (Ranbaxy (UK) Ltd) res41: SSRI ADDs Multilex drug
63703020 Paroxetine 20mg tablets (IVAX Pharmaceuticals UK Ltd) res41: SSRI ADDs Multilex drug
64692020 Fluoxetine 20mg/5ml oral solution (Teva UK Ltd) res41: SSRI ADDs Multilex drug
64717020 Fluoxetine 20mg/5ml oral solution (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
65125020 Citalopram 10mg tablets (Sandoz Ltd) res41: SSRI ADDs Multilex drug
65128020 Citalopram 20mg tablets (Sandoz Ltd) res41: SSRI ADDs Multilex drug
65131020 Citalopram 40mg tablets (Sandoz Ltd) res41: SSRI ADDs Multilex drug
65254020 Citalopram 10mg Tablet (Neo Laboratories Ltd) res41: SSRI ADDs Multilex drug
65257020 Citalopram 20mg Tablet (Neo Laboratories Ltd) res41: SSRI ADDs Multilex drug
65262020 Citalopram 40mg Tablet (Neo Laboratories Ltd) res41: SSRI ADDs Multilex drug
65376020 Citalopram 10mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
65381020 Citalopram 20mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
65386020 Citalopram 40mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
65464020 Fluoxetine 60mg capsules (Generics (UK) Ltd) res41: SSRI ADDs Multilex drug
65578020 Paroxetine 20mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
66129020 Fluoxetine 20mg/5ml oral solution (IVAX Pharmaceuticals UK Ltd) res41: SSRI ADDs Multilex drug
66149020 Citalopram 10mg tablets (Zentiva) res41: SSRI ADDs Multilex drug
66152020 Citalopram 20mg tablets (Zentiva) res41: SSRI ADDs Multilex drug
66160020 Citalopram 40mg tablets (Zentiva) res41: SSRI ADDs Multilex drug
66244020 Fluvoxamine 100mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
66273020 Fluoxetine 20mg capsules (Tillomed Laboratories Ltd) res41: SSRI ADDs Multilex drug
66399020 Paroxetine 20mg tablets (Generics (UK) Ltd) res41: SSRI ADDs Multilex drug
66451020 Citalopram 10mg tablets (Generics (UK) Ltd) res41: SSRI ADDs Multilex drug
66454020 Citalopram 20mg tablets (Generics (UK) Ltd) res41: SSRI ADDs Multilex drug
66459020 Citalopram 40mg tablets (Generics (UK) Ltd) res41: SSRI ADDs Multilex drug
66464020 Paroxetine 20mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
66680020 Citalopram 10mg tablets (Niche Generics Ltd) res41: SSRI ADDs Multilex drug
66685020 Citalopram 20mg tablets (Niche Generics Ltd) res41: SSRI ADDs Multilex drug
66688020 Citalopram 40mg tablets (Niche Generics Ltd) res41: SSRI ADDs Multilex drug
67575020 Paroxetine 30mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
67650020 Paroxetine 30mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
67890020 Citalopram 10mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
67893020 Citalopram 20mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
67898020 Citalopram 40mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
68042020 Citalopram 10mg tablets (Teva UK Ltd) res41: SSRI ADDs Multilex drug
68045020 Citalopram 20mg tablets (Teva UK Ltd) res41: SSRI ADDs Multilex drug
68049020 Citalopram 40mg tablets (Teva UK Ltd) res41: SSRI ADDs Multilex drug
69506020 Prozac 20mg capsules (Eli Lilly and Company Ltd) res41: SSRI ADDs Multilex drug
69507020 Prozac 20mg/5ml liquid (Eli Lilly and Company Ltd) res41: SSRI ADDs Multilex drug
69508020 Prozac 60mg capsules (Eli Lilly and Company Ltd) res41: SSRI ADDs Multilex drug
69654020 Fluoxetine 20mg capsules res41: SSRI ADDs Multilex drug
69655020 Fluoxetine 20mg/5ml oral solution res41: SSRI ADDs Multilex drug
69656020 Fluoxetine 60mg capsules res41: SSRI ADDs Multilex drug
69754020 Paroxetine 20mg tablets (Genus Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
71214020 Citalopram 10mg tablets (PLIVA Pharma Ltd) res41: SSRI ADDs Multilex drug
71225020 Citalopram 10mg tablets (IVAX Pharmaceuticals UK Ltd) res41: SSRI ADDs Multilex drug
71373020 Citalopram 10mg tablets (Almus Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
71376020 Citalopram 20mg tablets (Almus Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
71725020 Sertraline 50mg tablets (A A H Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
72034020 Sertraline 50mg tablets (Actavis UK Ltd) res41: SSRI ADDs Multilex drug
72095020 Sertraline 100mg tablets (Teva UK Ltd) res41: SSRI ADDs Multilex drug
72932020 Paroxetine 20mg tablets res41: SSRI ADDs Multilex drug
72933020 Paroxetine 30mg tablets res41: SSRI ADDs Multilex drug
72934020 Paroxetine 10mg/5ml oral suspension sugar free res41: SSRI ADDs Multilex drug
72937020 Seroxat 20mg tablets (GlaxoSmithKline UK Ltd) res41: SSRI ADDs Multilex drug
72938020 Seroxat 30mg tablets (GlaxoSmithKline UK Ltd) res41: SSRI ADDs Multilex drug
72939020 Seroxat 20mg/10ml liquid (GlaxoSmithKline UK Ltd) res41: SSRI ADDs Multilex drug
74046020 Lustral 50mg tablets (Pfizer Ltd) res41: SSRI ADDs Multilex drug
74047020 Lustral 100mg tablets (Pfizer Ltd) res41: SSRI ADDs Multilex drug
74050020 Sertraline 50mg tablets res41: SSRI ADDs Multilex drug
74051020 Sertraline 100mg tablets res41: SSRI ADDs Multilex drug
74425020 Fluoxetine 20mg Capsule (Milpharm Ltd) res41: SSRI ADDs Multilex drug
75620020 Sertraline 50mg tablets (Almus Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
77306020 Citalopram 40mg/ml oral drops sugar free res41: SSRI ADDs Multilex drug
77312020 Cipramil 40mg/ml drops (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
78768020 Escitalopram 10mg tablets res41: SSRI ADDs Multilex drug
79420020 Cipramil 20mg tablets (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
79421020 Cipramil 10mg tablets (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
79422020 Cipramil 40mg tablets (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
79462020 Citalopram 20mg tablets res41: SSRI ADDs Multilex drug
79463020 Citalopram 10mg tablets res41: SSRI ADDs Multilex drug
79464020 Citalopram 40mg tablets res41: SSRI ADDs Multilex drug
80679020 Oxactin 20mg capsules (Discovery Pharmaceuticals Ltd) res41: SSRI ADDs Multilex drug
80777020 Prozit 20mg/5ml oral solution (Pinewood Healthcare) res41: SSRI ADDs Multilex drug
82055020 Ranflutin 20mg capsules (Ranbaxy (UK) Ltd) res41: SSRI ADDs Multilex drug
86222020 Cipralex 10mg tablets (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
87524020 Escitalopram 5mg tablets res41: SSRI ADDs Multilex drug
87526020 Cipralex 5mg tablets (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
88346020 Paxoran 10mg Tablet (Ranbaxy (UK) Ltd) res41: SSRI ADDs Multilex drug
88348020 Paxoran 20mg Tablet (Ranbaxy (UK) Ltd) res41: SSRI ADDs Multilex drug
90497020 Sertraline 50mg/5ml oral suspension res41: SSRI ADDs Multilex drug
90871020 Escitalopram 10mg/ml oral drops sugar free res41: SSRI ADDs Multilex drug
90873020 Cipralex 10mg/ml oral drops (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
92043020 Paroxetine 10mg tablets res41: SSRI ADDs Multilex drug
93187020 Seroxat 10mg tablets (GlaxoSmithKline UK Ltd) res41: SSRI ADDs Multilex drug
93918020 Prozep 20mg/5ml oral solution (Chemidex Pharma Ltd) res41: SSRI ADDs Multilex drug
93984020 Fluoxetine 20mg/5ml oral solution sugar free res41: SSRI ADDs Multilex drug
97169020 Escitalopram 20mg/ml oral drops sugar free res41: SSRI ADDs Multilex drug
97171020 Cipralex 20mg/ml oral drops (Lundbeck Ltd) res41: SSRI ADDs Multilex drug
98001020 Fluoxetine 10mg tablets res41: SSRI ADDs Multilex drug

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH395/version/790/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH395/version/790/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH395', '790', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH395/version/790/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH395/version/790/export/codes/?format=json
CSV site_root/phenotypes/PH395/version/790/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH395', '790', api_client=client)

Version History

Version
ID
Name Owner Publish date
790 selective serotonin reuptake inhibitor (SSRI) Adds ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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