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Hypothyroidism

Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves

Type
Disease or Syndrome
ID
PH424
Version ID
848
Data Sources
Valid event data range
01/01/2000 - 31/12/2007
Sex
Female, Male
Agreement Date
2011-06-28
Coding system
Read codes v2 OXMIS codes
Tags /Collections
ClinicalCodes Repository Phenotype Library

Definition

Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.

Publications

  • Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011.

Clinical Code List

Rows: 35
Code Description Entity type Coding System (OXMIS Read) Category
C03..00 Congenital hypothyroidism hypothyroidism Read diagnostic
C03y.00 Other specified congenital hypothyroidism hypothyroidism Read diagnostic
C03y000 Congenital hypothyroidism with diffuse goitre hypothyroidism Read diagnostic
C03y100 Congenital hypothyroidism without goitre hypothyroidism Read diagnostic
C03z.00 Congenital hypothyroidism NOS hypothyroidism Read diagnostic
C04..00 Acquired hypothyroidism hypothyroidism Read diagnostic
C04..11 Myxoedema hypothyroidism Read diagnostic
C04..12 Thyroid deficiency hypothyroidism Read diagnostic
C04..13 Hypothyroidism hypothyroidism Read diagnostic
C040.00 Postsurgical hypothyroidism hypothyroidism Read diagnostic
C040.11 Post ablative hypothyroidism hypothyroidism Read diagnostic
C041.00 Other postablative hypothyroidism hypothyroidism Read diagnostic
C041000 Irradiation hypothyroidism hypothyroidism Read diagnostic
C041z00 Postablative hypothyroidism NOS hypothyroidism Read diagnostic
C042.00 Iodine hypothyroidism hypothyroidism Read diagnostic
C043.00 Other iatrogenic hypothyroidism hypothyroidism Read diagnostic
C043000 Hypothyroidism resulting from para-aminosalicylic acid hypothyroidism Read diagnostic
C043100 Hypothyroidism resulting from phenylbutazone hypothyroidism Read diagnostic
C043200 Hypothyroidism resulting from resorcinol hypothyroidism Read diagnostic
C043z00 Iatrogenic hypothyroidism NOS hypothyroidism Read diagnostic
C044.00 Postinfectious hypothyroidism hypothyroidism Read diagnostic
C045.00 Acquired atrophy of thyroid hypothyroidism Read diagnostic
C046.00 Autoimmune myxoedema hypothyroidism Read diagnostic
C04y.00 Other acquired hypothyroidism hypothyroidism Read diagnostic
C04z.00 Hypothyroidism NOS hypothyroidism Read diagnostic
C04z.11 Pretibial myxoedema - hypothyroid hypothyroidism Read diagnostic
C04z.12 Thyroid insufficiency hypothyroidism Read diagnostic
C04z.13 Hypothyroid goitre; acquired hypothyroidism Read diagnostic
C04z000 Premature puberty due to hypothyroidism hypothyroidism Read diagnostic
C04z100 Myxoedema coma hypothyroidism Read diagnostic
Cyu1100 [X]Other sp cified hypothyroidism hypothyroidism Read diagnostic
F381400 Myasthenic syndrome due to hypothyroidism hypothyroidism Read diagnostic
f921.00 THYROXINE hypothyroidism Read diagnostic
f922.00 THYROXINE tabs 50micrograms hypothyroidism Read diagnostic
f923.00 THYROXINE tabs 100micrograms hypothyroidism Read diagnostic
Rows: 3
Code Description Entity type Coding System (OXMIS Read) Category
243 HYPOTHYROIDISM CONGENITAL hypothyroidism OXMIS diagnostic
244 AC HYPOTHYROIDISM ACQUIRED hypothyroidism OXMIS diagnostic
244 AG HYPOTHYROIDISM COMPENSATED hypothyroidism OXMIS diagnostic

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH424/version/848/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH424/version/848/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH424', '848', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH424/version/848/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH424/version/848/export/codes/?format=json
CSV site_root/phenotypes/PH424/version/848/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH424', '848', api_client=client)

Version History

Version
ID
Name Owner Publish date
848 Hypothyroidism ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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