Phenotype Library | phenotype: Hypothyroidism

Hypothyroidism

Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves

PH424

Version ID

848

Type

Disease or Syndrome

Data Sources

CPRD GOLD

Valid event data range

01/01/2000 - 31/12/2007

Sex

♀ Female ♂ Male

Agreement Date

2011-06-28

Coding system

Read codes v2 OXMIS codes

Collections

ClinicalCodes Repository Phenotype Library

Definition

Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.

Publications

Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011.

Clinical Code List

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C1774/4686 Hypothyroidism - Primary Care - Read codes v2

Rows: 35

Code	Description	Entity type	Coding System (OXMIS Read)	Category
C03..00	Congenital hypothyroidism	hypothyroidism	Read	diagnostic
C03y.00	Other specified congenital hypothyroidism	hypothyroidism	Read	diagnostic
C03y000	Congenital hypothyroidism with diffuse goitre	hypothyroidism	Read	diagnostic
C03y100	Congenital hypothyroidism without goitre	hypothyroidism	Read	diagnostic
C03z.00	Congenital hypothyroidism NOS	hypothyroidism	Read	diagnostic
C04..00	Acquired hypothyroidism	hypothyroidism	Read	diagnostic
C04..11	Myxoedema	hypothyroidism	Read	diagnostic
C04..12	Thyroid deficiency	hypothyroidism	Read	diagnostic
C04..13	Hypothyroidism	hypothyroidism	Read	diagnostic
C040.00	Postsurgical hypothyroidism	hypothyroidism	Read	diagnostic
C040.11	Post ablative hypothyroidism	hypothyroidism	Read	diagnostic
C041.00	Other postablative hypothyroidism	hypothyroidism	Read	diagnostic
C041000	Irradiation hypothyroidism	hypothyroidism	Read	diagnostic
C041z00	Postablative hypothyroidism NOS	hypothyroidism	Read	diagnostic
C042.00	Iodine hypothyroidism	hypothyroidism	Read	diagnostic
C043.00	Other iatrogenic hypothyroidism	hypothyroidism	Read	diagnostic
C043000	Hypothyroidism resulting from para-aminosalicylic acid	hypothyroidism	Read	diagnostic
C043100	Hypothyroidism resulting from phenylbutazone	hypothyroidism	Read	diagnostic
C043200	Hypothyroidism resulting from resorcinol	hypothyroidism	Read	diagnostic
C043z00	Iatrogenic hypothyroidism NOS	hypothyroidism	Read	diagnostic
C044.00	Postinfectious hypothyroidism	hypothyroidism	Read	diagnostic
C045.00	Acquired atrophy of thyroid	hypothyroidism	Read	diagnostic
C046.00	Autoimmune myxoedema	hypothyroidism	Read	diagnostic
C04y.00	Other acquired hypothyroidism	hypothyroidism	Read	diagnostic
C04z.00	Hypothyroidism NOS	hypothyroidism	Read	diagnostic
C04z.11	Pretibial myxoedema - hypothyroid	hypothyroidism	Read	diagnostic
C04z.12	Thyroid insufficiency	hypothyroidism	Read	diagnostic
C04z.13	Hypothyroid goitre; acquired	hypothyroidism	Read	diagnostic
C04z000	Premature puberty due to hypothyroidism	hypothyroidism	Read	diagnostic
C04z100	Myxoedema coma	hypothyroidism	Read	diagnostic
Cyu1100	[X]Other sp cified hypothyroidism	hypothyroidism	Read	diagnostic
F381400	Myasthenic syndrome due to hypothyroidism	hypothyroidism	Read	diagnostic
f921.00	THYROXINE	hypothyroidism	Read	diagnostic
f922.00	THYROXINE tabs 50micrograms	hypothyroidism	Read	diagnostic
f923.00	THYROXINE tabs 100micrograms	hypothyroidism	Read	diagnostic

C1775/4688 Hypothyroidism - Primary Care - OXMIS codes

Rows: 3

Code	Description	Entity type	Coding System (OXMIS Read)	Category
243	HYPOTHYROIDISM CONGENITAL	hypothyroidism	OXMIS	diagnostic
244 AC	HYPOTHYROIDISM ACQUIRED	hypothyroidism	OXMIS	diagnostic
244 AG	HYPOTHYROIDISM COMPENSATED	hypothyroidism	OXMIS	diagnostic

API

To Export Phenotype Details:

Format	API
XML	site_root/api/v1/public/phenotypes/PH424/version/848/detail/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH424/version/848/detail/?format=json
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get details of phenotype details = get_phenotype_detail_by_version('PH424', '848', api_client=client)`

To Export Phenotype Code List:

Format	API
XML	site_root/api/v1/public/phenotypes/PH424/version/848/export/codes/?format=xml
JSON	site_root/api/v1/public/phenotypes/PH424/version/848/export/codes/?format=json
CSV	site_root/phenotypes/PH424/version/848/export/codes/
R Package	`# Download here library(ConceptLibraryClient) # Connect to API client = connect_to_API(public=TRUE) # Get codelists of phenotype codelists = get_phenotype_code_list('PH424', '848', api_client=client)`

Version History

Version ID	Name	Owner	Publish date
848	Hypothyroidism	ieuan.scanlon	2021-10-06	currently shown