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Lithium Levels

Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves

ID
PH427
Version ID
854
Type
Biomarker
Data Sources
Valid event data range
01/01/2000 - 31/12/2007
Sex
♀  Female ♂  Male
Agreement Date
2011-06-28
Coding system
Read codes v2 OXMIS codes
Collections
ClinicalCodes Repository Phenotype Library
Tags
No tags

Definition

Patient level data were extracted from the General Practice Research Database (GPRD), which contains anonymised, patient based data on morbidity, prescribing, treatment, and referral collected from over 500 general practices, covering about 7% of the UK population (4.4 million patients).14 Data are in Read code format—a hierarchical system used to code clinical data. Additional data on prescriptions and test results are available as free-text entries. We selected a sample of 148 practices that provided data to the GPRD continuously between January 2000 and December 2007, structured to include a range of list (patient panel) sizes. Selected practices were nationally representative in terms of patient sex and age distribution and area socioeconomic deprivation but had a relatively large average list size, reflecting a bias towards larger practices in the GPRD. Overall, the selected practices performed marginally better than national practices on the clinical indicators in the Quality and Outcomes Framework. A random selection of 4500 patients registered for at least one day between 1 January 2000 and 31 December 2007 was drawn from each practice. For practices with fewer than 4501 patients, all patients were selected. The final sample consisted of 653 500 patients. Patients with relevant conditions were identified from their diagnostic Read codes. Patients for whom targets were met were identified from the relevant Read codes and free-text terms.

Publications

  • Tim Doran, Evangelos Kontopantelis, Jose M Valderas, Stephen Campbell, Martin Roland, Chris Salisbury, David Reeves, Effect of financial incentives on incentivised and non-incentivised clinical activities: longitudinal analysis of data from the UK Quality and Outcomes Framework. BMJ, 342:d3590, 2011.

Clinical Code List

Rows: 15
Code Description Entity type Coding System (OXMIS Read) Category
44W8.00 Serum lithium level Lithium levels Read diagnostic
44W8.11 Lithium: blood level Lithium levels Read diagnostic
44W8000 Lithium level therapeutic Lithium levels Read diagnostic
44W8100 Lithium level high - toxic Lithium levels Read diagnostic
44W8200 Lithium level low Lithium levels Read diagnostic
44vE.00 Lithium level therapeutic Lithium levels Read diagnostic
46P3.00 Urine lithium Lithium levels Read diagnostic
6657.00 On lithium Lithium levels Read diagnostic
6657.11 Lithium monitoring Lithium levels Read diagnostic
6657.12 Started lithium Lithium levels Read diagnostic
665B.00 Lithium stopped Lithium levels Read diagnostic
R105300 [D]Lithium; blood level abnormal Lithium levels Read diagnostic
d615.00 Lithium levels Read diagnostic
d616.00 Lithium levels Read diagnostic
d61z.00 Lithium levels Read diagnostic
Rows: 8
Code Description Entity type Coding System (OXMIS Read) Category
9859 TOXICITY LITHIUM Lithium levels OXMIS diagnostic
L 130L SERUM LITHIUM LEVEL Lithium levels OXMIS diagnostic
L 130L9 LITHIUM LEVEL (mmol/l) Lithium levels OXMIS diagnostic
L 130LA LITHIUM LEVEL Lithium levels OXMIS diagnostic
L 130LB LITHIUM LEVEL LOW Lithium levels OXMIS diagnostic
L 130LC LITHIUM LEVEL THERAPEUTIC Lithium levels OXMIS diagnostic
L 130LD LITHIUM LEVEL HIGH Lithium levels OXMIS diagnostic
T3551CA LITHIUM THERAPY Lithium levels OXMIS diagnostic

API

To Export Phenotype Details:

Format API
XML site_root/api/v1/public/phenotypes/PH427/version/854/detail/?format=xml
JSON site_root/api/v1/public/phenotypes/PH427/version/854/detail/?format=json
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get details of phenotype

details = get_phenotype_detail_by_version('PH427', '854', api_client=client)

To Export Phenotype Code List:

Format API
XML site_root/api/v1/public/phenotypes/PH427/version/854/export/codes/?format=xml
JSON site_root/api/v1/public/phenotypes/PH427/version/854/export/codes/?format=json
CSV site_root/phenotypes/PH427/version/854/export/codes/
R Package

# Download here

library(ConceptLibraryClient)


# Connect to API

client = connect_to_API(public=TRUE)


# Get codelists of phenotype

codelists = get_phenotype_code_list('PH427', '854', api_client=client)

Version History

Version
ID
Name Owner Publish date
854 Lithium Levels ieuan.scanlon 2021-10-06 currently shown

Export - export all codes into a csv file/JSON/XML for the current phenotype version.

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